公开(公告)号：KR1020090015766A

公开(公告)日：2009-02-12

申请号：KR1020070080366

申请日：2007-08-09

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  이용규 ,  이지연 ,  변세은 ,  김주영 ,  김병훈

IPC: A61K31/435 ,  A61P29/00 ,  A61P37/02 ,  A61P35/00

CPC classification number: Y02A50/409 ,  A61K31/435 ,  Y10S514/814 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/925

Abstract: A composition comprising 8-(tosylamino)quinoline is provided to inhibit production of nitric oxide, growth of cancer cells and C6 glioma cell, production of PGE2(prostaglandin 2), and activity of IKK(I kappa B alpha kinase) and Src kinase, thereby preventing or treating inflammatory diseases, immune diseases or tumors. The composition for preventing or treating inflammatory diseases, immune diseases or tumors comprises 8-(tosylamino)quinoline or pharmaceutically acceptable salts thereof including an acid addition salt selected from hydrochloric acid, hydrobromic acid, phosphonic acid, sulfuric acid, tartaric acid, acetic acid, citric acid, malic acid, methanesulphonic acid and gluconic acid.

Abstract translation: 提供了包含8-（甲苯磺酰氨基）喹啉的组合物以抑制一氧化氮的产生，癌细胞和C6胶质瘤细胞的生长，PGE2（前列腺素2）的产生以及IKK（IκBα激酶）和Src激酶的活性， 从而预防或治疗炎性疾病，免疫疾病或肿瘤。 用于预防或治疗炎性疾病，免疫疾病或肿瘤的组合物包含8-（甲苯磺酰氨基）喹啉或其药学上可接受的盐，包括选自盐酸，氢溴酸，膦酸，硫酸，酒石酸，乙酸， 柠檬酸，苹果酸，甲磺酸和葡萄糖酸。

公开(公告)号：KR100905387B1

公开(公告)日：2009-06-30

申请号：KR1020080097396

申请日：2008-10-02

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  김종대 ,  김병훈

IPC: A61K36/29 ,  A61P29/00

Abstract: A composition of solvent extract from Berberis koreana Palibin is provided to suppress the generation of nitric oxide, TNF-alpha and prostaglandin E2(PGE2) and regulates the function of macrophage. A method for manufacturing a butanol fraction of Berberis koreana Palibin comprises: a step of extracting the Berberis koreana Palibin in the water of 20-100°C to obtain concentrate; a step of suspending the concentrate with water and a step of fraction-extracting the suspension with hexane, ethylacetate and butanol. A pharmaceutical composition for treating inflammatory disease or immune-modulating comprises the butanol fraction of water extract of Berberis koreana Palibin. The inflammatory disease is arthritis, the sepsis, and inflammation or the autoimmune disease.

Abstract translation: 提供小檗碱溶剂提取物的组合物，以抑制一氧化氮，TNF-α和前列腺素E2（PGE2）的产生并调节巨噬细胞的功能。 一种制备小檗的丁醇馏分的方法包括：在20-100℃的水中提取小檗Berberin获得浓缩物的步骤; 用水悬浮浓缩物的步骤和用己烷，乙酸乙酯和丁醇分馏提取悬浮液的步骤。 用于治疗炎性疾病或免疫调节的药物组合物包含小檗Berberis水提取物的丁醇级分。 炎性疾病是关节炎，败血症，炎症或自身免疫性疾病。