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公开(公告)号：KR101448582B1
公开(公告)日：2014-10-13
申请号：KR1020140053257
申请日：2014-05-02
Applicant: 강원대학교산학협력단
IPC: C07F9/6571 , C07B41/00
CPC classification number: C07F9/657181 , C07F9/657172 , C07F9/65744
Abstract: The present invention relates to a novel cyclic phosphinate derivative and a preparing method thereof, and more specifically the cyclic phosphinate derivative of the present invention comprises a benzooxaphosphole oxide derivative and a benzooxaphosphorine oxide derivative. The cyclic phosphinate derivative of the present invention has pharmacological activity and bioactivity, and can be used in novel drug development and synthesis of various pharmaceuticals as well as used as a basic structure of natural materials. In addition, the method for preparing the cyclic phosphinate derivative according to the present invention has strong points of preparing various cyclic phosphinate derivatives having high yield through a simple synthesizing process by conducting intramolecular carbon-oxygen coupling reaction of a phosphonic acid derivative with a palladium (Pd) catalyst, an oxidizing agent and a base.
Abstract translation: 本发明涉及一种新型的环状次膦酸酯衍生物及其制备方法，更具体地说，本发明的环状次膦酸酯衍生物包含苯并氧磷杂环磷酸酯衍生物和苯氧基磷氧化物衍生物。 本发明的环状次膦酸酯衍生物具有药理活性和生物活性，可用于各种药物的新药开发和合成，也可用作天然物质的基本结构。 此外，本发明的环状次膦酸酯衍生物的制备方法通过简单的合成方法通过使膦酸衍生物与钯的分子内碳 - 氧偶联反应来制备具有高收率的各种环状次膦酸酯衍生物的优点（ Pd）催化剂，氧化剂和碱。
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公开(公告)号：KR1020160079316A
公开(公告)日：2016-07-06
申请号：KR1020140190522
申请日：2014-12-26
Applicant: 강원대학교산학협력단
IPC: C07F9/6584
CPC classification number: C07F9/6584 , C07F9/65842 , C07F9/65844
Abstract: 본발명은새로운벤즈아자포스폴-3-온 1-옥사이드유도체및 이의제조방법에관한것이다. 본발명에따른벤즈아자포스폴-3-온 1-옥사이드유도체의제조방법은산화제와할로겐계첨가제존재하에출발물질인포스폰아마이드유도체의분자내산화성탄소-질소결합반응을통해선택적으로벤즈아자포스폴-3-온 1-옥사이드유도체를합성하는것을특징으로한다.
Abstract translation: 本发明涉及新型苯并氮杂-3-酮1-氧化物衍生物及其制备方法。 根据本发明，苯扎氮代-3-酮1-氧化物衍生物的制造方法通过作为起始原料的膦酰胺衍生物的氧化性碳 - 氮结合反应选择性合成苯扎氮代-3-酮1-氧化物衍生物， 存在氧化剂和卤素添加剂。 根据本发明，苯扎氮代-3-酮1-氧化物衍生物具有生理活性，可用于制药工业。
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公开(公告)号：KR101653991B1
公开(公告)日：2016-09-05
申请号：KR1020140190522
申请日：2014-12-26
Applicant: 강원대학교산학협력단
IPC: C07F9/6584
Abstract: 본발명은새로운벤즈아자포스폴-3-온 1-옥사이드유도체및 이의제조방법에관한것이다. 본발명에따른벤즈아자포스폴-3-온 1-옥사이드유도체의제조방법은산화제와할로겐계첨가제존재하에출발물질인포스폰아마이드유도체의분자내산화성탄소-질소결합반응을통해선택적으로벤즈아자포스폴-3-온 1-옥사이드유도체를합성하는것을특징으로한다.
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