公开(公告)号：KR101631513B1

公开(公告)日：2016-06-17

申请号：KR1020140193116

申请日：2014-12-30

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  신서현 ,  정연석 ,  전우형

IPC: C07F9/6574 ,  B01J23/44

CPC classification number: C07F9/65744 ,  B01J23/44

Abstract: 본발명은신규한벤조[1,2]옥사포스포린(benzo[1,2]oxaphosphorine) 유도체및 이의제조방법에관한것이다. 본발명의신규한벤조[1.2]옥사포스포린유도체는생리활성으로인하여제약산업및 작물보호제산업에이용할수 있는중요한원료물질또는중간체로이용될수 있다. 또한, 본발명에따른벤조[1,2]옥사포스포린유도체의제조방법은전이금속촉매를사용하여벤질포스피닉산 유도체의탄소-수소결합활성화반응을통해일산화탄소와의탄소-탄소및 탄소-산소결합을형성시켜다양한벤조[d][1.2]옥사포스포린유도체를경제적인비용으로원-팟으로우수한수율로제조할수 잇는장점이있다.

Abstract translation: 本发明涉及一种新的苯并[d] [1,2]氧代磷杂环衍生物及其制备方法。 根据本发明的苯并[d] [1,2]氧代磷杂环衍生物可以作为重要的原料或适用于制药工业和农作物保护工业的中间体，由于其生理活性。 此外，本发明的苯并[d] [1,2]氧代磷杂环衍生物的制备方法包括使用过渡金属催化剂进行苄基次膦酸衍生物的碳氢键活化反应，形成 碳 - 碳和碳 - 氧键与一氧化碳。 因此，该方法的优点在于可以在一锅法中以高产率和低成本获得各种苯并[d] [1,2]氧代磷杂环衍生物。

公开(公告)号：KR101448582B1

公开(公告)日：2014-10-13

申请号：KR1020140053257

申请日：2014-05-02

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  신서현 ,  강동진 ,  엄다한 ,  김예린 ,  정연석 ,  최원석

IPC: C07F9/6571 ,  C07B41/00

CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

Abstract: The present invention relates to a novel cyclic phosphinate derivative and a preparing method thereof, and more specifically the cyclic phosphinate derivative of the present invention comprises a benzooxaphosphole oxide derivative and a benzooxaphosphorine oxide derivative. The cyclic phosphinate derivative of the present invention has pharmacological activity and bioactivity, and can be used in novel drug development and synthesis of various pharmaceuticals as well as used as a basic structure of natural materials. In addition, the method for preparing the cyclic phosphinate derivative according to the present invention has strong points of preparing various cyclic phosphinate derivatives having high yield through a simple synthesizing process by conducting intramolecular carbon-oxygen coupling reaction of a phosphonic acid derivative with a palladium (Pd) catalyst, an oxidizing agent and a base.

Abstract translation: 本发明涉及一种新型的环状次膦酸酯衍生物及其制备方法，更具体地说，本发明的环状次膦酸酯衍生物包含苯并氧磷杂环磷酸酯衍生物和苯氧基磷氧化物衍生物。 本发明的环状次膦酸酯衍生物具有药理活性和生物活性，可用于各种药物的新药开发和合成，也可用作天然物质的基本结构。 此外，本发明的环状次膦酸酯衍生物的制备方法通过简单的合成方法通过使膦酸衍生物与钯的分子内碳 - 氧偶联反应来制备具有高收率的各种环状次膦酸酯衍生物的优点（ Pd）催化剂，氧化剂和碱。