公开(公告)号：KR1020140128165A

公开(公告)日：2014-11-05

申请号：KR1020130047014

申请日：2013-04-26

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  강동진 ,  이의철 ,  박상준

IPC: C07F7/18 ,  B01J23/52 ,  C07B61/00

Abstract: 본발명은신규한엔올실릴이서유도체및 이의제조방법에관한것으로본 발명의신규한엔올실릴이서유도체는탄소-탄소결합형성에매우중요한화합물로사용될수 있으며, 본발명에따른엔올실릴이서유도체의제조방법은온화한조건에서간단한공정으로높은수율로엔올실릴이서유도체를얻을수 있다.

Abstract translation: 本发明涉及新型烯醇甲硅烷基醚衍生物及其制造方法。 本发明的新型烯醇甲硅烷基醚衍生物能够用作碳 - 碳键形成重要的化合物。 根据本发明的烯醇甲硅烷基醚衍生物的制造方法能够在温和条件下以简单的方法以高产率获得烯醇甲硅烷基醚衍生物。

公开(公告)号：KR101150970B1

公开(公告)日：2012-06-08

申请号：KR1020090132449

申请日：2009-12-29

Applicant: 강원대학교산학협력단

Inventor： 김진호 ,  이광무 ,  강동진 ,  이필호

IPC: C07C69/612 ,  C07C69/54 ,  C07C67/333

Abstract: [상기화학식 1에서 R내지 R은각각발명의상세한설명에서정의한바와같다.]

公开(公告)号：KR101448582B1

公开(公告)日：2014-10-13

申请号：KR1020140053257

申请日：2014-05-02

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  신서현 ,  강동진 ,  엄다한 ,  김예린 ,  정연석 ,  최원석

IPC: C07F9/6571 ,  C07B41/00

CPC classification number: C07F9/657181 ,  C07F9/657172 ,  C07F9/65744

Abstract: The present invention relates to a novel cyclic phosphinate derivative and a preparing method thereof, and more specifically the cyclic phosphinate derivative of the present invention comprises a benzooxaphosphole oxide derivative and a benzooxaphosphorine oxide derivative. The cyclic phosphinate derivative of the present invention has pharmacological activity and bioactivity, and can be used in novel drug development and synthesis of various pharmaceuticals as well as used as a basic structure of natural materials. In addition, the method for preparing the cyclic phosphinate derivative according to the present invention has strong points of preparing various cyclic phosphinate derivatives having high yield through a simple synthesizing process by conducting intramolecular carbon-oxygen coupling reaction of a phosphonic acid derivative with a palladium (Pd) catalyst, an oxidizing agent and a base.

Abstract translation: 本发明涉及一种新型的环状次膦酸酯衍生物及其制备方法，更具体地说，本发明的环状次膦酸酯衍生物包含苯并氧磷杂环磷酸酯衍生物和苯氧基磷氧化物衍生物。 本发明的环状次膦酸酯衍生物具有药理活性和生物活性，可用于各种药物的新药开发和合成，也可用作天然物质的基本结构。 此外，本发明的环状次膦酸酯衍生物的制备方法通过简单的合成方法通过使膦酸衍生物与钯的分子内碳 - 氧偶联反应来制备具有高收率的各种环状次膦酸酯衍生物的优点（ Pd）催化剂，氧化剂和碱。

公开(公告)号：KR101532564B1

公开(公告)日：2015-06-30

申请号：KR1020130047014

申请日：2013-04-26

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  강동진 ,  이의철 ,  박상준

IPC: C07F7/18 ,  B01J23/52 ,  C07B61/00

Abstract: 본발명은신규한엔올실릴이서유도체및 이의제조방법에관한것으로본 발명의신규한엔올실릴이서유도체는탄소-탄소결합형성에매우중요한화합물로사용될수 있으며, 본발명에따른엔올실릴이서유도체의제조방법은온화한조건에서간단한공정으로높은수율로엔올실릴이서유도체를얻을수 있다.

公开(公告)号：KR101437327B1

公开(公告)日：2014-09-04

申请号：KR1020130086700

申请日：2013-07-23

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  강동진 ,  조재영

IPC: C07F9/6574 ,  B01J23/44

CPC classification number: C07F9/65744 ,  B01J23/44

Abstract: The present invention provides a novel olefinated phosphachromone derivative compound and a method for producing the same. Moreover, the present invention provides a phosphachromone derivative compound having various structures and an effective method for producing the same, wherein the phosphachromone derivative compound is produced through a coupling reaction with olefin by activating a C-H bond in a desired position of a phosphachromone using a transition metal catalyst. Accordingly, the present invention can provide an olefinated phosphachromone derivative compound at a high yield, wherein reaction costs, reaction steps, and the use of time are very economical. The novel phosphachromone derivative compound of the present invention has physiological activities so that the same can be used as an important raw ingredient or intermediate which can be used for biomedical and pharmaceutical industries.

Abstract translation: 本发明提供一种新型烯化磷杂红酮衍生物化合物及其制备方法。 此外，本发明提供具有各种结构的磷杂红酮衍生物化合物及其制备方法，其中通过使用过渡金属氧化物的期望位置中的CH键活化而与烯烃进行偶联反应来制备磷杂过程中衍生物化合物 金属催化剂。 因此，本发明可以高产率提供烯化磷杂红酮衍生物化合物，其中反应成本，反应步骤和时间的使用是非常经济的。 本发明的新型磷杂红酮衍生物化合物具有生理活性，因此可以将其作为可用于生物医药和制药工业的重要原料或中间体使用。

公开(公告)号：KR101243612B1

公开(公告)日：2013-03-15

申请号：KR1020120069974

申请日：2012-06-28

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  박상준 ,  강동진

IPC: C07D307/78 ,  C07D307/28 ,  C07D491/048

Abstract: PURPOSE: A method for preparing a novel hydrofuran derivative is provided to simply obtain a hydrofuran derivative using a cheap copper catalyst. CONSTITUTION: A novel hydrofuran derivative contains a hydroisobenzo-furan derivative of chemical formula 1. In chemical formula 1, R^1 or R^2 is independently hydrogen, (C1-C6)alkyl group, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, (C3-C20)cycloalkyl, (C6-C20)aryl, or (C3-C20)heteroaryl.

Abstract translation: 目的：提供一种制备新型氢呋喃衍生物的方法，以简单地获得使用便宜的铜催化剂的氢呋喃衍生物。 化学式1中，R 1或R 2独立地是氢，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基， -C 6）烷氧基羰基，（C 3 -C 20）环烷基，（C 6 -C 20）芳基或（C 3 -C 20）杂芳基。

公开(公告)号：KR1020110075880A

公开(公告)日：2011-07-06

申请号：KR1020090132449

申请日：2009-12-29

Applicant: 강원대학교산학협력단

Inventor： 김진호 ,  이광무 ,  강동진 ,  이필호

IPC: C07C69/612 ,  C07C69/54 ,  C07C67/333

Abstract: PURPOSE: A method for preparing 2-aryl allenoate derivatives is provided to obtain 2-aryl allenoate derivatives with high yield through a cross coupling reaction of an organic indium reagent in the presence of an arene derivative and palladium catalyst, wherein the organic indium reagent is obtained in in-situ from the reaction of indium with 4-bromo-2-butenoate. CONSTITUTION: A method for preparing 2-aryl allenoate derivatives is represented by chemical formula 1. In chemical formula 1, R^1 and R^5 are hydrogen, (C1~C7) alkyl, halogen, (C6~C20) aryl or (C1~C7) alkoxycarbonyl; R^2 and R^4 are hydrogen, (C1~C7) alkoxy or nitro; R^3 is hydrogen, (C1~C7) alkyl, (C6~C20) aryl, halogen, formyl, acetyl, alkoxycarbonyl or (C6~C20) aryl (C1~C7) alkylcarbamoyl aryl; R^6 is hydrogen or (C1~C7) alkyl; and R^7 is (C1~C7) alkyl or (C6~C20) aryl.

Abstract translation: 目的：提供2-芳基烯酸酯衍生物的制备方法，通过有机铟试剂在芳族衍生物和钯催化剂的存在下的交叉偶联反应，以高产率得到2-芳基全烯酸酯衍生物，其中有机铟试剂为 由铟与4-溴-2-丁烯酸酯的反应原位获得。 化学式1中R 1和R 5为氢，（C 1 -C 7）烷基，卤素，（C 6〜C 20）芳基或（C 6〜C 20）芳基或 C1〜C7）烷氧基羰基; R 2和R 4是氢，（C 1 -C 7）烷氧基或硝基; 卤素，甲酰基，乙酰基，烷氧基羰基或（C6〜C20）芳基（C1〜C7）烷基氨基甲酰基芳基;（C1〜C7）烷基，（C1〜C7） R 6是氢或（C 1 -C 7）烷基; R 7为（C 1 -C 7）烷基或（C 6〜C 20）芳基。