公开(公告)号：KR1020090021024A

公开(公告)日：2009-02-27

申请号：KR1020070085733

申请日：2007-08-24

Applicant: 강원대학교산학협력단

Inventor： 배영수 ,  함연호 ,  김진규 ,  권동주

IPC: C07H1/08 ,  C07H15/203 ,  A61K31/7028 ,  A61K36/76

CPC classification number: C07H15/203 ,  C07H1/08

Abstract: A novel salicin derivative isolated from Populus albaglandulosa bark is provided to have the structure similar to aspirin and minimize the side effects in applications to the pharmaceutical field including anti-inflammatory agent, analgesic agent and antipyretic agent. The isolation method of the novel salicin derivative isolated from Populus albaglandulosa bark comprises the steps of: collecting the Populus albaglandulosa bark and dipping it in organic solvent; filtering the extract and evaporating the organic solvent in a concentrator; fractionating the evaporated extract with n-hexane, CH2Cl2 and EtOAc sequentially; freeze-drying the fraction to obtain EtOAc; fractionating the EtOAc through the multiple stages using MeOH-H2O as elution solvent; and subjecting the isolated fraction to column chromatography using MeOH-H2O.

Abstract translation: 提供了一种分离自山杨树皮的新型水杨酸衍生物，其结构类似于阿司匹林，并最大限度地减少了包括抗炎剂，止痛剂和解热剂在内的制药领域的副作用。 从山杨树皮分离出的新型水杨酸衍生物的分离方法包括以下步骤：收集山杨树皮并将其浸入有机溶剂中; 过滤提取物并在浓缩器中蒸发有机溶剂; 依次用正己烷，CH 2 Cl 2和EtOAc分馏蒸发的萃取液; 冷冻干燥该级分以获得EtOAc; 使用MeOH-H 2 O作为洗脱溶剂，通过多级分馏EtOAc; 并使用MeOH-H 2 O对分离的级分进行柱层析。

公开(公告)号：KR1020090021021A

公开(公告)日：2009-02-27

申请号：KR1020070085730

申请日：2007-08-24

Applicant: 강원대학교산학협력단

Inventor： 배영수 ,  김진규 ,  권동주

IPC: C07H1/08 ,  A61K31/7028 ,  A61K36/80

CPC classification number: C07H15/18 ,  C07H1/08

Abstract: A novel compound isolated from Paulownia coreana inner bark is provided to improve antioxidative activity, and help isolation and structure analysis of other useful natural materials, so that it is useful as new natural anti-oxidation agent or other medicines. The method for isolating the novel compound from Paulownia coreana inner bark comprises the steps of: collecting the Paulownia coreana inner bark and dipping it in 70% acetone; filtering the extract from the process and evaporating acetone by using a concentrator; fractionating the evaporated concentrate with n-hexane, CH2Cl2, and EtOAc sequentially; freeze-drying the water-soluble fraction as final product to obtain the water-soluble powder; and fractionating the water-soluble powder through the multiple stages using MeOH as elution solvent.

Abstract translation: 提供从泡桐核内分离出来的新型化合物，以提高抗氧化活性，有助于其他有用天然物质的分离和结构分析，从而可用作新的天然抗氧化剂或其他药物。 从泡桐内皮分离新化合物的方法包括以下步骤：收集泡桐内皮，并将其浸在70％丙酮中; 过滤来自该方法的提取物并通过使用浓缩器蒸发丙酮; 依次用正己烷，CH 2 Cl 2和EtOAc分馏蒸发浓缩物; 冷冻干燥水溶性级分作为最终产物，得到水溶性粉末; 并使用MeOH作为洗脱溶剂，通过多级级分水溶性粉末。