公开(公告)号：KR1020090021024A

公开(公告)日：2009-02-27

申请号：KR1020070085733

申请日：2007-08-24

Applicant: 강원대학교산학협력단

Inventor： 배영수 ,  함연호 ,  김진규 ,  권동주

IPC: C07H1/08 ,  C07H15/203 ,  A61K31/7028 ,  A61K36/76

CPC classification number: C07H15/203 ,  C07H1/08

Abstract: A novel salicin derivative isolated from Populus albaglandulosa bark is provided to have the structure similar to aspirin and minimize the side effects in applications to the pharmaceutical field including anti-inflammatory agent, analgesic agent and antipyretic agent. The isolation method of the novel salicin derivative isolated from Populus albaglandulosa bark comprises the steps of: collecting the Populus albaglandulosa bark and dipping it in organic solvent; filtering the extract and evaporating the organic solvent in a concentrator; fractionating the evaporated extract with n-hexane, CH2Cl2 and EtOAc sequentially; freeze-drying the fraction to obtain EtOAc; fractionating the EtOAc through the multiple stages using MeOH-H2O as elution solvent; and subjecting the isolated fraction to column chromatography using MeOH-H2O.

Abstract translation: 提供了一种分离自山杨树皮的新型水杨酸衍生物，其结构类似于阿司匹林，并最大限度地减少了包括抗炎剂，止痛剂和解热剂在内的制药领域的副作用。 从山杨树皮分离出的新型水杨酸衍生物的分离方法包括以下步骤：收集山杨树皮并将其浸入有机溶剂中; 过滤提取物并在浓缩器中蒸发有机溶剂; 依次用正己烷，CH 2 Cl 2和EtOAc分馏蒸发的萃取液; 冷冻干燥该级分以获得EtOAc; 使用MeOH-H 2 O作为洗脱溶剂，通过多级分馏EtOAc; 并使用MeOH-H 2 O对分离的级分进行柱层析。