公开(公告)号：KR101755089B1

公开(公告)日：2017-07-06

申请号：KR1020150008747

申请日：2015-01-19

Applicant: 강원대학교산학협력단

Inventor： 배영수 ,  김웅진 ,  이승환

IPC: A61K36/185 ,  A23L1/30

Abstract: 본발명은계수나무 (Cericidiphyllum japonicum) 추출물을유효성분으로포함하는항당뇨용조성물에관한것이다. 본발명의계수나무추출물은당뇨치료제인아카보스와유사한정도의α-글루코시다아제억제활성을가지고있어당뇨치료제의활성성분으로개발될가능성이높다. 본발명의계수나무추출물은천연물로부터유래되었으므로화학적으로합성된화합물과는다르게인체적용시부작용이적다.

Abstract translation: 本发明涉及含有连香树提取物作为有效成分的抗糖尿病组合物。 本发明的肉桂提取物有大约类似于糖尿病阿卡波糖的α-葡萄糖苷酶抑制活性可能被开发为糖尿病的有效成分。 由于本发明的决明子提取物来源于天然产物，与化学合成的化合物不同，当施用于人体时，其副作用小。

公开(公告)号：KR1020090021024A

公开(公告)日：2009-02-27

申请号：KR1020070085733

申请日：2007-08-24

Applicant: 강원대학교산학협력단

Inventor： 배영수 ,  함연호 ,  김진규 ,  권동주

IPC: C07H1/08 ,  C07H15/203 ,  A61K31/7028 ,  A61K36/76

CPC classification number: C07H15/203 ,  C07H1/08

Abstract: A novel salicin derivative isolated from Populus albaglandulosa bark is provided to have the structure similar to aspirin and minimize the side effects in applications to the pharmaceutical field including anti-inflammatory agent, analgesic agent and antipyretic agent. The isolation method of the novel salicin derivative isolated from Populus albaglandulosa bark comprises the steps of: collecting the Populus albaglandulosa bark and dipping it in organic solvent; filtering the extract and evaporating the organic solvent in a concentrator; fractionating the evaporated extract with n-hexane, CH2Cl2 and EtOAc sequentially; freeze-drying the fraction to obtain EtOAc; fractionating the EtOAc through the multiple stages using MeOH-H2O as elution solvent; and subjecting the isolated fraction to column chromatography using MeOH-H2O.

Abstract translation: 提供了一种分离自山杨树皮的新型水杨酸衍生物，其结构类似于阿司匹林，并最大限度地减少了包括抗炎剂，止痛剂和解热剂在内的制药领域的副作用。 从山杨树皮分离出的新型水杨酸衍生物的分离方法包括以下步骤：收集山杨树皮并将其浸入有机溶剂中; 过滤提取物并在浓缩器中蒸发有机溶剂; 依次用正己烷，CH 2 Cl 2和EtOAc分馏蒸发的萃取液; 冷冻干燥该级分以获得EtOAc; 使用MeOH-H 2 O作为洗脱溶剂，通过多级分馏EtOAc; 并使用MeOH-H 2 O对分离的级分进行柱层析。

公开(公告)号：KR1020100000693A

公开(公告)日：2010-01-06

申请号：KR1020080060286

申请日：2008-06-25

Applicant: 강원대학교산학협력단

Inventor： 이재선 ,  배영수 ,  원무호 ,  김영섭 ,  유시용 ,  황인구 ,  유기연 ,  박진서 ,  강일준

IPC: A23L1/29 ,  A23L1/30

CPC classification number: A23L33/105 ,  A23L33/125 ,  A23V2002/00 ,  A23V2200/302 ,  A23V2250/21

Abstract: PURPOSE: A functional food for promoting differentiation of neutral stem cell containing platycodon root extract as an active ingredient is provided to suppress the reduction of differentiation of proliferation of neutral stem cells caused by aging and to promote differentiation of proliferation of neutral stem cells. CONSTITUTION: A functional food comprises platycodon root extract as an active ingredient to promote differentiation of proliferation of neutral stem cells. The nerve stem cells are derivated from dentate gyrus subgranular zone of hippocampus. The differentiation of the stem cell comprises the production of stem cells, fission, differentiation and movement. The platycodon root extract is obtained by cutting the dried platycodon root; extracting it at 20-150deg.C through enfleurage extraction, hot water extraction, ultrasonic extraction, and extraction under reflux condensation.

Abstract translation: 目的：提供一种促进中性干细胞含有桔梗根提取物作为活性成分的功能性食品，以抑制由老化引起的中性干细胞增殖分化的减少，并促进中性干细胞增殖的分化。 构成：功能性食品包括桔梗根提取物作为活性成分，促进中性干细胞增殖的分化。 神经干细胞衍生自海马齿状回颗粒亚区域。 干细胞的分化包括干细胞的产生，分裂，分化和运动。 通过切割干燥的桔梗根获得桔梗根提取物; 通过灌肠提取，热水提取，超声提取，回流冷凝提取，在20-150℃下萃取。

公开(公告)号：KR1020160089158A

公开(公告)日：2016-07-27

申请号：KR1020150008747

申请日：2015-01-19

Applicant: 강원대학교산학협력단

Inventor： 배영수 ,  김웅진 ,  이승환

IPC: A61K36/185 ,  A23L1/30

CPC classification number: A61K36/185 ,  A23L33/105

Abstract: 본발명은계수나무 (Cericidiphyllum japonicum) 추출물을유효성분으로포함하는항당뇨용조성물에관한것이다. 본발명의계수나무추출물은당뇨치료제인아카보스와유사한정도의α-글루코시다아제억제활성을가지고있어당뇨치료제의활성성분으로개발될가능성이높다. 본발명의계수나무추출물은천연물로부터유래되었으므로화학적으로합성된화합물과는다르게인체적용시부작용이적다.

Abstract translation: 本发明涉及一种抗糖尿病组合物，其包含日本枸杞提取物作为活性成分。 本发明的Cercidiphyllum japonicum提取物具有与阿卡波糖水平相似的α-葡糖苷酶抑制活性，阿卡波糖是用于治疗糖尿病的药物，因此被开发为用于治疗糖尿病的药剂的活性成分。 衍生自天然物质的本发明的枸杞提取物在与人体不同的化学合成化合物上施用时具有降低的副作用。

公开(公告)号：KR1020090021021A

公开(公告)日：2009-02-27

申请号：KR1020070085730

申请日：2007-08-24

Applicant: 강원대학교산학협력단

Inventor： 배영수 ,  김진규 ,  권동주

IPC: C07H1/08 ,  A61K31/7028 ,  A61K36/80

CPC classification number: C07H15/18 ,  C07H1/08

Abstract: A novel compound isolated from Paulownia coreana inner bark is provided to improve antioxidative activity, and help isolation and structure analysis of other useful natural materials, so that it is useful as new natural anti-oxidation agent or other medicines. The method for isolating the novel compound from Paulownia coreana inner bark comprises the steps of: collecting the Paulownia coreana inner bark and dipping it in 70% acetone; filtering the extract from the process and evaporating acetone by using a concentrator; fractionating the evaporated concentrate with n-hexane, CH2Cl2, and EtOAc sequentially; freeze-drying the water-soluble fraction as final product to obtain the water-soluble powder; and fractionating the water-soluble powder through the multiple stages using MeOH as elution solvent.

Abstract translation: 提供从泡桐核内分离出来的新型化合物，以提高抗氧化活性，有助于其他有用天然物质的分离和结构分析，从而可用作新的天然抗氧化剂或其他药物。 从泡桐内皮分离新化合物的方法包括以下步骤：收集泡桐内皮，并将其浸在70％丙酮中; 过滤来自该方法的提取物并通过使用浓缩器蒸发丙酮; 依次用正己烷，CH 2 Cl 2和EtOAc分馏蒸发浓缩物; 冷冻干燥水溶性级分作为最终产物，得到水溶性粉末; 并使用MeOH作为洗脱溶剂，通过多级级分水溶性粉末。