公开(公告)号：KR101454459B1

公开(公告)日：2014-10-23

申请号：KR1020130065254

申请日：2013-06-07

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  박영철 ,  김진식 ,  김성각 ,  바토주찬드라카리

IPC: C07F9/22 ,  B01J23/44

CPC classification number: C07F9/222 ,  B01J23/44

Abstract: The present invention can manufacture a novel phosphoramidate derivative. An orthoarylation reaction according to the present invention can manufacture a phosphoramidate derivative by an effective manufacturing method with high yield for short reaction time at mild reaction temperature while increasing site selectivity (ortho) by using a phosphoramidate directing group under the presence of a palladium catalyst, an additive and an oxidizing agent. The phosphoramidate derivative according to the present invention can be used as an important raw material or an intermediate capable of being used in bio-medical and pharmaceutical industries by physiological activity.

Abstract translation: 本发明可以制造新的氨基磷酸酯衍生物。 根据本发明的正辛基化反应可以通过有效的制备方法制备氨基磷酸酯衍生物，其通过在钯催化剂存在下通过使用氨基磷酸酯引导基团提高位点选择性（邻位），在温和的反应温度下反应时间短，产率高， 添加剂和氧化剂。 根据本发明的氨基磷酸酯衍生物可以用作重要的原料或能够通过生理活性用于生物医药和制药工业的中间体。