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公开(公告)号：KR101606347B1
公开(公告)日：2016-03-29
申请号：KR1020130162353
申请日：2013-12-24
Applicant: 강원대학교산학협력단
Abstract: 본발명은팔라듐촉매와첨가제를사용하여페닐포스페이트의원하는위치의 C-H 결합을활성화하여바이닐화합물과의반응을통해다양한구조의 2-바이닐페닐포스페이트유도체화합물및 효율적인제조방법을제공하였다. 또한본 발명에의해제조된 신규한 2-바이닐페닐포스페이트유도체화합물은천연물의기본골격으로사용될뿐만아니라이를통해신약개발및 다양한의약품의개발이가능하다.
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公开(公告)号：KR1020120043191A
公开(公告)日：2012-05-04
申请号：KR1020100104367
申请日：2010-10-26
Applicant: 강원대학교산학협력단
CPC classification number: C07F9/12 , B01J31/2404 , B01J2531/18 , B01J2531/90
Abstract: PURPOSE: An enol phosphate derivative and a method for preparing the same are provided to enable synthesis of natural products and physiologically active materials. CONSTITUTION: An enol phosphate derivative is denoted by chemical formula 1. A method for preparing enol phosphate derivative comprises: a step of reacting alkane derivative of chemical formula 2 with a phosphate derivative of chemical formula 4 under the presence of a gold catalyst to prepare kinetic enol phosphate derivative of chemical formula A. The gold catalyst includes AuCl, AuCl_3, AuBr_3, PPh_3AuCl, (C_6F_5)_3PAuCl, (IPr)AuCl, or (IMes)AuCl.
Abstract translation: 目的：提供烯醇磷酸酯衍生物及其制备方法，以使天然产物和生理活性物质合成。 烯烃磷酸酯衍生物由化学式1表示。一种制备烯醇磷酸酯衍生物的方法包括：在金催化剂存在下使化学式2的烷烃衍生物与化学式4的磷酸酯衍生物反应以制备动力学的步骤 金催化剂包括AuCl，AuCl_3，AuBr_3，PPh_3AuCl，（C_6F_5）_3PAuCl，（IPr）AuCl或（IMes）AuCl。
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Patent Agency Ranking
公开(公告)号：KR1020150075156A
公开(公告)日：2015-07-03
申请号：KR1020130162353
申请日：2013-12-24
Applicant: 강원대학교산학협력단
Abstract: 본발명은팔라듐촉매와첨가제를사용하여페닐포스페이트의원하는위치의 C-H 결합을활성화하여바이닐화합물과의반응을통해다양한구조의 2-바이닐페닐포스페이트유도체화합물및 효율적인제조방법을제공하였다. 또한본 발명에의해제조된 신규한 2-바이닐페닐포스페이트유도체화합물은천연물의기본골격으로사용될뿐만아니라이를통해신약개발및 다양한의약품의개발이가능하다.
Abstract translation: 本发明提供一种2-乙烯基苯基磷酸酯衍生物化合物及其有效制备方法，其中2-乙烯基苯基磷酸酯衍生物化合物与乙烯基化合物的反应具有各种结构，通过在苯基磷酸酯的所需位置活化CH键 通过使用钯催化剂和添加剂。 此外，2-乙烯基苯基磷酸酯衍生物化合物不仅可以用作天然物质的基本结构，而且可以开发成新型药物和各种药物和医疗用品。
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公开(公告)号：KR101228381B1
公开(公告)日：2013-01-31
申请号：KR1020110031169
申请日：2011-04-05
Applicant: 강원대학교산학협력단
IPC: C07C45/61 , C07C49/537 , C07C69/753 , C07D307/80
Abstract: 본 발명은 철 촉매를 이용하여 α-알키닐 β-케토에스터 화합물의 분자내 고리화 반응을 통하여 온화한 조건하에서 보다 간단한 방법을 통해 높은 수율로 5각고리 화합물을 합성하는 제조방법을 제공한다.
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公开(公告)号：KR101210428B1
公开(公告)日：2012-12-10
申请号：KR1020100104367
申请日：2010-10-26
Applicant: 강원대학교산학협력단
Abstract: 본발명은하기화학식 1로표시되는엔올포스페이트유도체및 이의제조방법에관한것이다. 보다상세하게는, 서로다른금 촉매계를이용하여알카인유도체를포스페이트유도체와의첨가반응을통하여하기화학식 A로표시되는카이네틱(kinetic) 엔올포스페이트유도체와하기화학식 B로표시되는써모다이나믹(thermodynamic) 엔올포스페이트유도체를각각선택적으로제조하는방법에관한것이다. [화학식 1][화학식 A][화학식 B]상기화학식 1, 화학식 A 및화학식 B에서 R, R, R및 R는각각발명의상세한설명에서정의한바와같다.
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公开(公告)号：KR101454459B1
公开(公告)日：2014-10-23
申请号：KR1020130065254
申请日：2013-06-07
Applicant: 강원대학교산학협력단
Abstract: The present invention can manufacture a novel phosphoramidate derivative. An orthoarylation reaction according to the present invention can manufacture a phosphoramidate derivative by an effective manufacturing method with high yield for short reaction time at mild reaction temperature while increasing site selectivity (ortho) by using a phosphoramidate directing group under the presence of a palladium catalyst, an additive and an oxidizing agent. The phosphoramidate derivative according to the present invention can be used as an important raw material or an intermediate capable of being used in bio-medical and pharmaceutical industries by physiological activity.
Abstract translation: 本发明可以制造新的氨基磷酸酯衍生物。 根据本发明的正辛基化反应可以通过有效的制备方法制备氨基磷酸酯衍生物，其通过在钯催化剂存在下通过使用氨基磷酸酯引导基团提高位点选择性（邻位），在温和的反应温度下反应时间短，产率高， 添加剂和氧化剂。 根据本发明的氨基磷酸酯衍生物可以用作重要的原料或能够通过生理活性用于生物医药和制药工业的中间体。
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公开(公告)号：KR1020120113453A
公开(公告)日：2012-10-15
申请号：KR1020110031169
申请日：2011-04-05
Applicant: 강원대학교산학협력단
IPC: C07C45/61 , C07C49/537 , C07C69/753 , C07D307/80
Abstract: PURPOSE: A method for manufacturing pentacyclic compound using a simple method through intracyclization reaction of A-alkynyl B-ketoester compound are provided to manufacture the pentacyclic compound at high yield. CONSTITUTION: A method for manufacturing pentacyclic compound includes a step of manufacturing the pentacyclic compound represented by chemical formula 1 under the presence of an iron catalyst. In the chemical formula 1 or 5, R is selected from C1-C7 alkyl, C3-C8 cycloalkyl, C6-C20 aryl, or C3-C20 heteroaryl. R^1 is selected from C6-C20 arylamino and the C1-C7 alkoxy. R^2 is selected from hydrogen, C1-C7 alkyl or C6-C20 aryl.
Abstract translation: 目的：提供使用简单方法通过α-炔基B-酮酯化合物的内环化反应制备五环化合物的方法，以高产率制备五环化合物。 构成：制备五环化合物的方法包括在铁催化剂存在下制备由化学式1表示的五环化合物的步骤。 在化学式1或5中，R选自C 1 -C 7烷基，C 3 -C 8环烷基，C 6 -C 20芳基或C 3 -C 20杂芳基。 R 1选自C 6 -C 20芳基氨基和C 1 -C 7烷氧基。 R 2选自氢，C 1 -C 7烷基或C 6 -C 20芳基。
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