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Patent Agency Ranking
公开(公告)号：KR101029091B1
公开(公告)日：2011-04-13
申请号：KR1020100032177
申请日：2010-04-08
Applicant: 강원대학교산학협력단
IPC: C07D307/26 , C07D307/28
Abstract: PURPOSE: A method for preparing dihydrofuran derivative is provided to selectively prepare dihydrofuran derivative with high yield by a simple test. CONSTITUTION: A dihydrofuran derivative of chemical formula 1 is prepared by intramolecular cyclization of alenyl alcohol derivative of chemical formula 2 under the presence of a cupper salt catalyst of CuCl, CuBr, CuI, CuOTf, Cu(OTf)2, CuCl2, CuBr2, CuI_2, or Cu(OAc)_2, or solvent of N,N-dimethylformamide(DMF), or N,N-dimethylaceteamide(DMA). The organic solvent is dichloromethane(DCM), dichloroethane(DCE), toluene, acetonitrile(MeCN), nitromethane, tetrahydrofuran(THF), N,N-dimehtylformamide(DMF), or N,N-dimethylaceteamide(DMA).
Abstract translation: 目的：提供制备二氢呋喃衍生物的方法，通过简单的试验选择性地制备二氢呋喃衍生物，产率高。 构成：化学式1的二氢呋喃衍生物通过在CuCl，CuBr，CuI，CuOTf，Cu（OTf）2，CuCl 2，CuBr 2，CuI 2的铜盐催化剂存在下，通过化学式2的烯丙醇衍生物的分子内环化制备 ，或Cu（OAc）2，或N，N-二甲基甲酰胺（DMF）或N，N-二甲基乙酰胺（DMA）的溶剂。 有机溶剂是二氯甲烷（DCM），二氯乙烷（DCE），甲苯，乙腈（MeCN），硝基甲烷，四氢呋喃（THF），N，N-二甲基甲酰胺（DMF）或N，N-二甲基乙酰胺（DMA）。
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公开(公告)号：KR1020150014210A
公开(公告)日：2015-02-06
申请号：KR1020130089596
申请日：2013-07-29
Applicant: 강원대학교산학협력단
IPC: C07D263/57 , A61K31/423 , B01J23/50
CPC classification number: C07D263/57 , A61K31/423 , B01J23/50
Abstract: 본발명은하기화학식 1로표시되는알키닐레이션(alkynylation) 된벤즈옥사졸(benzoxazole) 유도체의제조방법에관한것으로, 보다상세하게는, 팔라듐촉매, 포스핀계리간드로 1,3-bis(diphenylphosphino)propane 존재하에서은염(silver salt), 프로피올릭산(propiolic acid) 및벤즈옥사졸화합물을반응시켜알키닐레이션(alkynylation) 된벤즈옥사졸유도체의제조방법에관한것이다.
Abstract translation: 本发明涉及一种制备由化学式1表示的炔氧化的唑唑恶唑衍生物的方法，更具体地说，涉及一种通过使银板，丙炔酸和苯并恶唑化合物在钯的存在下反应制备炔基化的唑唑恶唑衍生物的方法 催化剂和1,3-双（二苯基膦基）丙烷作为膦类催化剂。
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公开(公告)号：KR101540623B1
公开(公告)日：2015-07-31
申请号：KR1020130089596
申请日：2013-07-29
Applicant: 강원대학교산학협력단
IPC: C07D263/57 , A61K31/423 , B01J23/50
Abstract: 본발명은하기화학식 1로표시되는알키닐레이션(alkynylation) 된벤즈옥사졸(benzoxazole) 유도체의제조방법에관한것으로, 보다상세하게는, 팔라듐촉매, 포스핀계리간드로 1,3-bis(diphenylphosphino)propane 존재하에서은염(silver salt), 프로피올릭산(propiolic acid) 및벤즈옥사졸화합물을반응시켜알키닐레이션(alkynylation) 된벤즈옥사졸유도체의제조방법에관한것이다.
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公开(公告)号：KR101454459B1
公开(公告)日：2014-10-23
申请号：KR1020130065254
申请日：2013-06-07
Applicant: 강원대학교산학협력단
Abstract: The present invention can manufacture a novel phosphoramidate derivative. An orthoarylation reaction according to the present invention can manufacture a phosphoramidate derivative by an effective manufacturing method with high yield for short reaction time at mild reaction temperature while increasing site selectivity (ortho) by using a phosphoramidate directing group under the presence of a palladium catalyst, an additive and an oxidizing agent. The phosphoramidate derivative according to the present invention can be used as an important raw material or an intermediate capable of being used in bio-medical and pharmaceutical industries by physiological activity.
Abstract translation: 本发明可以制造新的氨基磷酸酯衍生物。 根据本发明的正辛基化反应可以通过有效的制备方法制备氨基磷酸酯衍生物，其通过在钯催化剂存在下通过使用氨基磷酸酯引导基团提高位点选择性（邻位），在温和的反应温度下反应时间短，产率高， 添加剂和氧化剂。 根据本发明的氨基磷酸酯衍生物可以用作重要的原料或能够通过生理活性用于生物医药和制药工业的中间体。
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公开(公告)号：KR1020140098468A
公开(公告)日：2014-08-08
申请号：KR1020130011146
申请日：2013-01-31
Applicant: 강원대학교산학협력단
IPC: C07C315/06 , C07C317/10 , C07B61/00
Abstract: The present invention relates a method for manufacturing alkenyl triflate derivatives represented as chemical formula 1. The manufacturing method of the present invention has benefits not only to reduce reaction byproducts through addition reaction of tribonding derivatives and trifluoro methane sulfonate but also to streamline reaction steps to one step and to manufacture alkenyl triflate derivatives in high yield.
Abstract translation: 本发明涉及一种化学式1表示的三氟甲磺酸烯基酯衍生物的制造方法。本发明的制造方法不仅有利于通过加入各种衍生物和三氟甲磺酸盐的反应来还原反应副产物，还有助于将反应步骤简化为一 并以高产率制备链烯基三氟甲磺酸酯衍生物。
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