公开(公告)号：KR101368076B1

公开(公告)日：2014-02-27

申请号：KR1020130020566

申请日：2013-02-26

Applicant: 강원대학교산학협력단

Inventor： 이상명 ,  김기현 ,  장상호 ,  이길환 ,  정진하 ,  이남훈 ,  윤제필 ,  이슬비

IPC: B82B1/00 ,  C09K11/00 ,  G01N33/533

Abstract: The present invention relates to fluorescent silica nanoparticles, a composition including the fluorescent silica nanoparticles, a preparing method of the fluorescent silica nanoparticles, and a detecting method of biomolecules using the fluorescent silica nanoparticles. Concretely, The present invention relates to fluorescent silica nanoparticles which is surface-modified by a surface modifier thereby having high aqueous dispersibility with fluorescent materials adapted, a manufacturing method of the fluorescent silica nanoparticles, and a detecting method of biomolecules using the fluorescent silica nanoparticles. The fluorescent silica nanoparticle can be used in various biological or medical fields such as display fields, fluorescence microscopes, image diagnosis probe, biochip, and biosensor because it has fluorescent materials adapted and joined antibodies, and besides, it is acidic in aqueous solutions. Besides, by the manufacturing method of the fluorescent silica nanoparticles according to the present invention, fluorescent silica nanoparticles with excellent aqueous dispersibility can be obtained and antibodies can be introduced into the flurescent silica nanoparticles through a simple step.

Abstract translation: 本发明涉及荧光二氧化硅纳米颗粒，包含荧光二氧化硅纳米颗粒的组合物，荧光二氧化硅纳米颗粒的制备方法和使用荧光二氧化硅纳米颗粒的生物分子的检测方法。 具体地，本发明涉及通过表面改性剂表面改性的荧光二氧化硅纳米粒子，其具有适于荧光材料的高水分散性，荧光二氧化硅纳米粒子的制造方法和使用荧光二氧化硅纳米粒子的生物分子的检测方法。 荧光二氧化硅纳米颗粒可用于各种生物或医学领域，如显示领域，荧光显微镜，图像诊断探针，生物芯片和生物传感器，因为它具有适应和连接抗体的荧光材料，此外，它在水溶液中是酸性的。 此外，通过本发明的荧光二氧化硅纳米粒子的制造方法，可以获得具有优异的水分散性的荧光二氧化硅纳米颗粒，并且可以通过简单的步骤将抗体引入到火山灰二氧化硅纳米颗粒中。