公开(公告)号：KR101883096B1

公开(公告)日：2018-07-27

申请号：KR1020170039385

申请日：2017-03-28

Applicant: 강원대학교산학협력단

Inventor： 박정란 ,  양세란 ,  장상호 ,  김석인 ,  황정순

IPC: A61K38/06 ,  A23L33/18

CPC classification number: A61K38/06 ,  A23L33/18 ,  A23V2002/00 ,  A23V2200/314

Abstract: 본발명은쿠퍼펩타이드를포함하는급성폐 손상또는급성호흡곤란증후군예방또는치료용약학조성물, 쿠퍼펩타이드를포함하는급성폐 손상또는급성호흡곤란증후군예방또는개선용건강기능성식품조성물및 상기약학조성물을급성폐 손상또는급성호흡곤란증후군의발병가능성이있거나또는급성폐 손상또는급성호흡곤란증후군을앓고있는개체에투여하는단계를포함하는, 급성폐 손상또는급성호흡곤란증후군의예방또는치료방법에관한것이다. 본발명의 GHK-Cu를포함하는조성물은급성폐 손상또는급성호흡곤란증후군유도동물모델에서우수한치료효과를나타내었으므로, 급성폐 손상또는급성호흡곤란증후군의예방, 치료또는개선에널리활용될수 있을것이다.

公开(公告)号：KR101368076B1

公开(公告)日：2014-02-27

申请号：KR1020130020566

申请日：2013-02-26

Applicant: 강원대학교산학협력단

Inventor： 이상명 ,  김기현 ,  장상호 ,  이길환 ,  정진하 ,  이남훈 ,  윤제필 ,  이슬비

IPC: B82B1/00 ,  C09K11/00 ,  G01N33/533

Abstract: The present invention relates to fluorescent silica nanoparticles, a composition including the fluorescent silica nanoparticles, a preparing method of the fluorescent silica nanoparticles, and a detecting method of biomolecules using the fluorescent silica nanoparticles. Concretely, The present invention relates to fluorescent silica nanoparticles which is surface-modified by a surface modifier thereby having high aqueous dispersibility with fluorescent materials adapted, a manufacturing method of the fluorescent silica nanoparticles, and a detecting method of biomolecules using the fluorescent silica nanoparticles. The fluorescent silica nanoparticle can be used in various biological or medical fields such as display fields, fluorescence microscopes, image diagnosis probe, biochip, and biosensor because it has fluorescent materials adapted and joined antibodies, and besides, it is acidic in aqueous solutions. Besides, by the manufacturing method of the fluorescent silica nanoparticles according to the present invention, fluorescent silica nanoparticles with excellent aqueous dispersibility can be obtained and antibodies can be introduced into the flurescent silica nanoparticles through a simple step.

Abstract translation: 本发明涉及荧光二氧化硅纳米颗粒，包含荧光二氧化硅纳米颗粒的组合物，荧光二氧化硅纳米颗粒的制备方法和使用荧光二氧化硅纳米颗粒的生物分子的检测方法。 具体地，本发明涉及通过表面改性剂表面改性的荧光二氧化硅纳米粒子，其具有适于荧光材料的高水分散性，荧光二氧化硅纳米粒子的制造方法和使用荧光二氧化硅纳米粒子的生物分子的检测方法。 荧光二氧化硅纳米颗粒可用于各种生物或医学领域，如显示领域，荧光显微镜，图像诊断探针，生物芯片和生物传感器，因为它具有适应和连接抗体的荧光材料，此外，它在水溶液中是酸性的。 此外，通过本发明的荧光二氧化硅纳米粒子的制造方法，可以获得具有优异的水分散性的荧光二氧化硅纳米颗粒，并且可以通过简单的步骤将抗体引入到火山灰二氧化硅纳米颗粒中。