公开(公告)号：KR101372833B1

公开(公告)日：2014-03-11

申请号：KR1020110091153

申请日：2011-09-08

Applicant: 강원대학교산학협력단

Inventor： 이정형 ,  이현선

IPC: A61K31/352 ,  A61K31/37 ,  A61K31/35 ,  A61P9/00

Abstract: 본 발명은 탄게레틴(tangeretin)을 유효성분으로 함유하는 평활근 세포의 증식 또는 이동 억제 효과가 있는 조성물에 관한 것으로, 상기 조성물은 동맥경화증, 고혈압, 협심증, 심근경색, 허혈성 심장질환, 심부전, 경혈관 동맥 성형술 후 발생하는 합병증, 뇌경색, 뇌출혈, 및, 뇌졸중 등과 같은 혈관 질환을 예방 및 치료할 수 있으며, 상기 질병들을 개선할 수 있는 다양한 치료제에도 유용하게 응용될 수 있다.

公开(公告)号：KR1020130027745A

公开(公告)日：2013-03-18

申请号：KR1020110091153

申请日：2011-09-08

Applicant: 강원대학교산학협력단

Inventor： 이정형 ,  이현선

IPC: A61K31/352 ,  A61K31/37 ,  A61K31/35 ,  A61P9/00

Abstract: PURPOSE: A composition containing tangeretin for preventing or treating vascular diseases is provided to suppress proliferation or migration of vascular smooth muscle cells. CONSTITUTION: A pharmaceutical composition for preventing or treating vascular diseases contains tangeretin of chemical formula 1. The vascular disease is selected from the group consisting of atherosclerosis, hypertension, angina pectoris, cardiac infarction, ischemic heart disease, heart failure, cerebral infarction, and stroke. The pharmaceutical composition is used in the form of a powder, a granule, a tablet, a capsule, a suspension, an emulsion, a syrup, an aerosol, an external use formulation, a suppository, and a sterilized injection solution.

Abstract translation: 目的：提供含有预防或治疗血管疾病的苦参碱的组合物，以抑制血管平滑肌细胞的增殖或迁移。 构成：用于预防或治疗血管疾病的药物组合物含有化学式1的苦参碱。血管疾病选自动脉粥样硬化，高血压，心绞痛，心肌梗塞，缺血性心脏病，心力衰竭，脑梗塞和中风 。 药物组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，气雾剂，外用制剂，栓剂和灭菌注射液的形式使用。

公开(公告)号：KR101049041B1

公开(公告)日：2011-07-13

申请号：KR1020110032470

申请日：2011-04-08

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  강은진 ,  김혜진 ,  이현선

IPC: A61K36/704 ,  A61P29/00 ,  A61P37/00

CPC classification number: A61K36/70 ,  A23V2200/324 ,  A61K2236/333 ,  Y10S514/886

Abstract: PURPOSE: A methanol extract of Persicaria hydropiper (L.) SPACH is provided to suppress NO generation and TNF-alpha and AP-1 expression. CONSTITUTION: A methanol extract of Persicaria hydropiper (L.) SPACH with anti-inflammatory and immunosuppressive effects contains quercetin 3-O-beta-L-rhamnoside, kaempferol-3-glucoside, 6-hydrolxyapigenin, galloyl kaepferol 3-glucoside, scutellarein, 6-hydroxylutelin, 6-hydroxyluteolin-7-O-beta-D-glucopyranoside, quercetin 3-O-beta-D-glucuronide, galloyl, quercetin, and quercetin flavonoid.

Abstract translation: 目的：提供Persicaria hydropiper（L.）SPACH的甲醇提取物以抑制NO产生和TNF-α和AP-1表达。 构成：具有抗炎和免疫抑制作用的Persicaria hydropiper（L.）SPACH的甲醇提取物含有槲皮素3-O-β-L-鼠李糖苷，山奈酚-3-葡萄糖苷，6-羟丙基青霉素，galloyl kaepferol 3-葡萄糖苷，scutellarein， 6-羟基脯氨酸-7-O-β-D-吡喃葡萄糖苷，槲皮素3-O-β-D-葡糖苷酸，酰基，槲皮素和槲皮素类黄酮。