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公开(公告)号：KR1020110039527A
公开(公告)日：2011-04-19
申请号：KR1020110030405
申请日：2011-04-01
Applicant: 국립암센터
IPC: A61K31/7105 , A61P35/00
CPC classification number: A61K31/7105
Abstract: PURPOSE: An anticancer composition containing micro RNA-125 nucleic acid molecule is provided to treat angiogenesis-associated diseases and to suppress cancer cell invasion and metastasis. CONSTITUTION: A composition for suppressing angiogenesis in hypoxic condition contains human-derived microRNA-125a, microRNA-125b1, or microRNA-125b2. A marker composition for diagnosing brain cancer or brain tumor contains an agent which measures microRNA-125 expression level. The microRNA-125 nucleic acid molecule suppresses cancer cell invasion and metastasis. The microRNA-125 nucleic acid molecule is used in treating angiogenesis-associated diseases, especially cancer, which are induced in hypoxia condition.
Abstract translation: 目的：提供含有微RNA-125核酸分子的抗癌组合物，用于治疗血管生成相关疾病，抑制癌细胞侵袭和转移。 构成：用于抑制缺氧条件下血管发生的组合物含有人源性微RNA-125a，microRNA-125b1或microRNA-125b2。 用于诊断脑癌或脑肿瘤的标记物组合物含有测量微小RNA-125表达水平的试剂。 microRNA-125核酸分子抑制癌细胞侵袭和转移。 microRNA-125核酸分子用于治疗在缺氧条件下诱导的血管生成相关疾病，特别是癌症。
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公开(公告)号：KR101043433B1
公开(公告)日：2011-06-22
申请号：KR1020080070087
申请日：2008-07-18
Applicant: 국립암센터
IPC: A61K31/7105 , A61P35/00
CPC classification number: A61K31/7105
Abstract: 본 발명은 마이크로RNA-125 핵산 분자를 포함하는 항암 조성물에 관한 것으로, 더욱 상세하게는 마이크로RNA-125(mir-125) 핵산 분자를 포함하는 저산소 상태에서 유도되는 혈관신생 관련 질환, 특히 암 치료를 위한 항암 조성물, 마이크로RNA-125 핵산 분자를 사용하여 혈관신생을 저해하거나 암세포 침윤 및 전이를 억제하는 방법, 및 마이크로RNA-125 핵산 분자를 포함하는 항암 조성물을 이용하여 암을 치료하는 방법에 관한 것이다.
암, 마이크로RNA-125, 저산소증, VEGF-
公开(公告)号：KR1020100009268A
公开(公告)日：2010-01-27
申请号：KR1020080070087
申请日：2008-07-18
Applicant: 국립암센터
IPC: A61K31/7105 , A61P35/00
CPC classification number: A61K31/7105
Abstract: PURPOSE: An anti-cancer composition containing microRNA-125 nucleic acid molecule is provided to suppress infiltration and metastasis of cancer cells and angiogenesis. CONSTITUTION: An anti-cancer composition containing microRNA-125 nucleic acid molecule. The microRNA-125 is a microRNA-125a, microRNA-125b1 or microRNA-125b2 which is derived from human. The cancer is brain cancer, cervical cancer, breast cancer, bladder cancer, liver cancer, prostate cancer, and neuroblastoma. The microRNA-125 nucleic acid molecule is contained in a vector for expressing in a cell. The vector is lentivirus vector, retrovirus vector, adenovirus vector, herpersvirus vector, or avipoxvirus vector. The composition further comprises a pharmaceutically acceptable carrier. A composition for treating angiogenesis-relating disease which is induced under hypoxic condition contains the microRNA-125 nucleic acid molecule.
Abstract translation: 目的：提供含有microRNA-125核酸分子的抗癌组合物，以抑制癌细胞浸润转移和血管生成。 构成：含有microRNA-125核酸分子的抗癌组合物。 microRNA-125是来自人的microRNA-125a，microRNA-125b1或microRNA-125b2。 癌症是脑癌，子宫颈癌，乳腺癌，膀胱癌，肝癌，前列腺癌和神经母细胞瘤。 微小RNA-125核酸分子包含在用于在细胞中表达的载体中。 载体是慢病毒载体，逆转录病毒载体，腺病毒载体，herpersvirus载体或avipoxvirus载体。 组合物还包含药学上可接受的载体。 用于治疗在缺氧条件下诱导的血管生成相关疾病的组合物含有微小RNA-125核酸分子。
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