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2.发明公开울금으로부터 데메톡시커큐민을 추출하는 방법, 이러한방법으로 추출된 데메톡시커큐민, 이의 유도체 및 이들을포함하는 기능성 음료 无效从CURCUMA AROMATICA提取DEMETHOXCURCUMIN的方法，通过该方法提取的DEMETHOXYCURCUMIN，其衍生物和包含其的功能性饮料
公开(公告)号：KR1020020075122A
公开(公告)日：2002-10-04
申请号：KR1020010015330
申请日：2001-03-23
Applicant: 권호정
IPC: C07C45/78
Abstract: PURPOSE: Provided are a method for effectively extracting and purifying a demethoxycurcumin(DC), which is a pharmacologically active material, from Curcuma aromatica, demethoxycurcumin extracted by the method, a derivative thereof, and functional beverages comprising the same. CONSTITUTION: The method for extracting demethoxycurcumin from Curcuma aromatica comprises heat treating Curcuma aromatica in 70-98% methanol solvent at 55-65 deg.C for 2-5 hours. The dimethylated demethoxycurcumin is represented by formula 2. The dimethylated demethoxycurcumin of formula 2 is synthesized by reacting demethoxycurcumin of formula 1 with methyl iodide and K2CO3 in acetone. The dimethylated demethoxycurcumin is useful to produce an agent for inhibiting the angiogenesis.
Abstract translation: 目的：提供一种有效提取和提纯来自姜黄的药物活性物质的脱甲氧基姜黄素（DC），通过该方法提取的脱甲氧基姜黄素及其衍生物，以及含有它们的功能性饮料。 构成：从姜黄提取脱甲氧基姜黄素的方法包括在70-98％甲醇溶剂中于55-65℃热处理姜黄姜黄2-5小时。 二甲基化脱甲氧基姜黄素由式2表示。式2的二甲基化脱甲氧基姜黄素通过使式1的脱甲氧基姜黄素与甲基碘和K 2 CO 3在丙酮中反应而合成。 二甲基化脱甲氧基姜黄素可用于制备抑制血管发生的药剂。
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公开(公告)号：KR1020030077496A
公开(公告)日：2003-10-01
申请号：KR1020030059285
申请日：2003-08-26
Applicant: 권호정
IPC: C07C251/54
Abstract: PURPOSE: Provided is demethoxycurcumin oxime having an activity inhibiting the generation of new blood vessels, which can be used for anticancer functional materials, especially beverages. CONSTITUTION: The demethoxycurcumin oxime represented by the formula 3 is synthesized by reacting demethoxycurcumin represented by the formula 1 with methyl iodide and K2CO3 in acetone. And the anticancer functional materials contain the demethoxycurcumin oxime and the beverage as the anticancer functional material additionally contains Bifidobacteria or Lactobacillus.
Abstract translation: 目的：提供具有抑制新血管生成的活性的脱甲氧基姜黄素肟，其可用于抗癌功能材料，特别是饮料。 构成：由式3表示的脱甲氧基姜黄素肟通过将由式1表示的脱甲氧基姜黄素与甲基碘和K 2 CO 3在丙酮中反应合成。 抗癌功能材料含有脱甲氧基姜黄素肟，作为抗癌功能材料的饮料还含有双歧杆菌或乳杆菌。
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公开(公告)号：KR1020010109831A
公开(公告)日：2001-12-12
申请号：KR1020000030484
申请日：2000-06-02
Applicant: 권호정 , 서울기능식품 주식회사 , 주식회사 비피도
IPC: C12N1/20
Abstract: 본 발명은 올레아미드를 생산하는 토양에서 분리된 신균주
Streptomyces sp. KK90378 (KCTC18014P)와 이 균주에 의해 올레아미드를 생산하는 방법에 관한 것이다. 본 발명에 따른 신균주는 올레아미드의 생산능이 높기 때문에, 이 균주를 배양하여 수면을 유도하는 생리활성 물질인 올레아미드를 생산하거나 균체를 담체에 고정하여 배양함으로써 수면을 유도하는 생리활성 물질인 올레아미드를 효율적으로 생산할 수 있다.-
Patent Agency Ranking
公开(公告)号：KR1020030076511A
公开(公告)日：2003-09-26
申请号：KR1020030059287
申请日：2003-08-26
Applicant: 권호정
IPC: C07D231/12
Abstract: PURPOSE: A demethoxycurcumin derivative and an anti-cancer agent containing the same compound are provided, which compound has angiogenesis inhibiting activity, so that it can be used in functional anticancer agents, especially drink type of functional anticancer agents. CONSTITUTION: A hydrazine demethoxycurcumin derivative represented by formula 4 is provided. A method for preparing the hydrazine demethoxycurcumin of formula 4 comprises reacting demethoxycurcumin of formula 1 with methyliodide and K2CO3 in acetone. An anti-cancer agent for inhibiting angiogenesis contains hydrazine demethoxycurcumin of formula 4, wherein the anti-cancer agent is drink further comprising Bifidobacteria or Lactobacillus as lactic acid bacteria.
Abstract translation: 目的：提供含有相同化合物的脱甲氧基姜黄素衍生物和抗癌剂，该化合物具有血管生成抑制活性，可用于功能性抗癌剂，特别是饮用型功能性抗癌剂。 构成：提供由式4表示的肼脱甲氧基姜黄素衍生物。 制备式4的肼脱甲氧基姜黄素的方法包括使式1的脱甲氧基姜黄素与丙酮中的甲基碘和K 2 CO 3反应。 用于抑制血管发生的抗癌剂含有式4的肼脱甲氧基姜黄素，其中所述抗癌剂进一步包含作为乳酸菌的双歧杆菌或乳杆菌。
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公开(公告)号：KR100386197B1
公开(公告)日：2003-06-02
申请号：KR1020000030484
申请日：2000-06-02
Applicant: 권호정 , 서울기능식품 주식회사 , 주식회사 비피도
IPC: C12N1/20
Abstract: 본 발명은 올레아미드를 생산하는 토양에서 분리된 신균주 스트렙토미세스속 KK90378(
Streptomyces sp. KK90378) (KCTC18014P)와 이 균주에 의해 올레아미드를 생산하는 방법에 관한 것이다. 본 발명에 따른 신균주는 올레아미드의 생산능이 높기 때문에, 이 균주를 배양하여 수면을 유도하는 생리활성 물질인 올레아미드를 생산하거나 균체를 담체에 고정하여 배양함으로써 수면을 유도하는 생리활성 물질인 올레아미드를 효율적으로 생산할 수 있다.-
公开(公告)号：KR100416334B1
公开(公告)日：2004-01-31
申请号：KR1020030059287
申请日：2003-08-26
Applicant: 권호정
IPC: C07D231/12
Abstract: PURPOSE: A demethoxycurcumin derivative and an anti-cancer agent containing the same compound are provided, which compound has angiogenesis inhibiting activity, so that it can be used in functional anticancer agents, especially drink type of functional anticancer agents. CONSTITUTION: A hydrazine demethoxycurcumin derivative represented by formula 4 is provided. A method for preparing the hydrazine demethoxycurcumin of formula 4 comprises reacting demethoxycurcumin of formula 1 with methyliodide and K2CO3 in acetone. An anti-cancer agent for inhibiting angiogenesis contains hydrazine demethoxycurcumin of formula 4, wherein the anti-cancer agent is drink further comprising Bifidobacteria or Lactobacillus as lactic acid bacteria.
Abstract translation: 目的：提供了一种含有相同化合物的去甲氧基姜黄素衍生物和抗癌剂，该化合物具有血管生成抑制活性，因此可用于功能性抗癌剂，特别是饮用型功能性抗癌剂。 构成：提供由式4表示的肼去甲氧基姜黄素衍生物。 用于制备式4的肼去甲氧基姜黄素的方法包括使式1的去甲氧基姜黄素与甲基碘和K 2 CO 3在丙酮中反应。 用于抑制血管生成的抗癌剂包含式4的肼去甲氧基姜黄素，其中所述抗癌剂是进一步包含双歧杆菌或乳酸杆菌作为乳酸菌的饮料。
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公开(公告)号：KR1020030075807A
公开(公告)日：2003-09-26
申请号：KR1020020015181
申请日：2002-03-20
Applicant: 권호정
IPC: C07C39/18
Abstract: PURPOSE: A novel bicyclic sesterterpene-based derivative and a pharmaceutical composition containing the derivative are provided, to obtain a pharmaceutical composition for treating or preventing the uncontrolled angiogenesis related disease. CONSTITUTION: The bicyclic sesterterpene-based derivative is represented by the formula 1, wherein R1, R2 and R3 are independently H, a linear or branched alkyl group, a linear or branched alkenyl group, a linear or branched alkynyl group, a cycloalkyl group, a cycloalkenyl group, an aryl group, an alkaryl group or an aralkyl group. Preferably R1, R2 and R3 are independently H or a methyl group in the formula 1. The pharmaceutical composition comprises the bicyclic sesterterpene-based derivative of the formula 1, and a pharmaceutically acceptable carrier.
Abstract translation: 目的：提供一种新型的双环西萜烯衍生物和含有该衍生物的药物组合物，以获得用于治疗或预防不受控制的血管生成相关疾病的药物组合物。 构成：双环辛萜基衍生物由式1表示，其中R 1，R 2和R 3独立地为H，直链或支链烷基，直链或支链烯基，直链或支链炔基，环烷基， 环烯基，芳基，烷芳基或芳烷基。 优选地，R 1，R 2和R 3独立地为H或式1中的甲基。药物组合物包含式1的双环西萜烯衍生物和药学上可接受的载体。
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公开(公告)号：KR1020030074552A
公开(公告)日：2003-09-19
申请号：KR1020030059286
申请日：2003-08-26
Applicant: 권호정
IPC: C07C45/78
Abstract: PURPOSE: Provided is a method for extracting and purifying demethoxycurcumin from Curcuma aromatica which is a Chinese medicine material with a high efficiency. CONSTITUTION: The method for extracting demethoxycurcumin having angiogenesis inhibiting activity of the formula 1 from Curcuma aromatica comprises the step of heat treating Curcuma aromatica in methanol or ethanol extraction solvent at the temperature of 40 to 70 deg.C. In particular, the extraction solvent is methanol having a concentration of 60-100%, and the heat treating step is carried out for 1 to 10 hours.
Abstract translation: 目的：提供一种高效中药的姜黄素提取纯化脱甲氧基姜黄素的方法。 构成：从姜黄中提取具有式1的血管生成抑制活性的脱甲氧基姜黄素的方法包括在40〜70℃的温度下在甲醇或乙醇提取溶剂中热处理姜黄的步骤。 特别地，提取溶剂为浓度为60〜100％的甲醇，热处理工序进行1〜10小时。
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