公开(公告)号：KR100790807B1

公开(公告)日：2008-01-04

申请号：KR1020060124569

申请日：2006-12-08

Applicant: 대한민국(농촌진흥청장)

Inventor： 황재삼 ,  윤은영 ,  안미영 ,  황석조 ,  방혜선 ,  강희윤 ,  김연주 ,  김익수 ,  구태원 ,  강석우

IPC: C07K14/00

Abstract: A novel sequence and an antibacterial peptide isolated from larvae of Copris tripartitus are provided to be usefully used as a prophylactic and therapeutic agent of bacterial diseases of human and plant and show antibacterial activity against various pathogenic bacteria. A sequence of an antibacterial peptide isolated from larvae of Copris tripartitus(SEQ ID : NO. 3) is represented by the following : AACGGTTCTG AATTCTTAAC CAGTTCATAC CCAGCTATAA TTTGAATTAC 50 GTCTTTTAAA AAGATGGCAA AATTAATTGC TTTTGCATTA GTAGCTTCGT 100 TATGCCTGTC TATGGTGTTG TGCAATCCGT TACCAGAAGA AGTCCAAGAA 150 GAGGGACTTG TCAGACAAAA AAGGGTAACC TGTGACGTGT TAAGTTTCGA 200 AGCCAAAGGA ATAGCTGTAA ATCATTCGGC TTGTGCGCTA CATTGTATTG 250 CCTTACGTAA AAAAGGTGGT TCTTGTCAAA ATGGTGTGTG TGTTTGTAGA 300 AATTAATTAA CAAGCTGATT GTCCTTTTTT TTAATTGTGG CCGGATGATA 350 TTATTTTCAG TGTAATAAGA ACAAAAATAA AGATTTATAA CTATTAAAAA 400 AAAAAAAAAA AA 412. A novel antibacterial peptide(SEQ ID : NO. 4) is encoded by the sequence and consists of an amino acid sequence of Met Ala Lys Leu Ile Ala Phe Ala Leu Val Ala Ser Leu Cys Leu 15 Ser Met Val Leu Cys Asn Pro Leu Pro Glu Glu Val Gln Glu Glu 30 Gly Leu Val Arg Gln Lys Arg Val Thr Cys Asp Val Leu Ser Phe 45 Glu Ala Lys Gly Ile Ala Val Asn His Ser Ala Cys Ala Leu His 60 Cys Ile Ala Leu Arg Lys Lys Gly Gly Ser Cys Gln Asn Gly Val 75 Cys Val Cys Arg Asn 80.

Abstract translation: 提供从Copris triartae的幼虫分离的新的序列和抗菌肽，有效地用作人和植物的细菌性疾病的预防和治疗剂，并且对各种致病菌具有抗菌活性。 （SEQ ID：NO 3）从Copris tripartitus的幼虫中分离的抗菌肽的序列：AACGGTTCTG AATTCTTAAC CAGTTCATAC CCAGCTATAA TTTGAATTAC 50 GTCTTTTAAA AAGATGGCAA AATTAATTGC TTTTGCATTA GTAGCTTCGT 100 TATGCCTGTC TATGGTGTTG TGCAATCCGT TACCAGAAGA AGTCCAAGAA 150 GAGGGACTTG TCAGACAAAA AAGGGTAACC TGTGACGTGT TAAGTTTCGA 200由下式表示 AGCCAAAGGA ATAGCTGTAA ATCATTCGGC TTGTGCGCTA CATTGTATTG 250 CCTTACGTAA AAAAGGTGGT TCTTGTCAAA ATGGTGTGTG TGTTTGTAGA 300 AATTAATTAA CAAGCTGATT GTCCTTTTTT TTAATTGTGG CCGGATGATA 350 TTATTTTCAG TGTAATAAGA ACAAAAATAA AGATTTATAA CTATTAAAAA 400 AAAAAAAAAA AA 412的新型抗菌肽（SEQ ID：NO：4）是由序列编码，由一个氨基的 Met Ala Lys Leu的氨基酸序列Ile Ala Phe Ala Leu Val Ala Ser Leu Cys Leu 15 Ser Met Val Leu Cys Asn Pro Leu Pro Glu Glu Val Gln Glu Glu 30 Gly Leu Val Arg Gln Lys Arg Val Thr Cys Asp Val Leu Ser Phe 45 Glu Ala Lys Gly Ile Ala Val Asn His Ser Ala Cys Ala Leu His 60 Cys Ile Ala Leu Arg Lys Lys Gly Gly Ser Cys Gln Asn Gly Val 75 Cys Val Cys Arg Asn 80。