Abstract:
양하에서 분리정제한 라브다-12-엔-15,16-디알 화합물 및 이의 분리 정제방법에 관한 것으로서, 양하의 화뢰와 근경을 음건하여 메탄올로 추출한 후 농축시켜 에틸아세테이트층, 부탄올층, 물층으로 분획화 하였으며, 에틸아세테이트층을 실리카겔 칼럼 크로마토그래피를 실시하여 라브다-12-엔-15,16-디알(labda-12-ene-15,16-dial) 화합물을 분리하였으며, NMR, IR등의 분광학적 방법을 이용하여 구조동정한 결과 하기 화학식 1의 신규의 화합물이다. (화학식 1)
라브다-12-엔-15,16-디알 화합물은 항균활성 및 항암활성을 가진다. 양하, 라브다-12-엔-15,16-디알, 의약품, 치료보조식품
Abstract:
PURPOSE: Provided is a labda-12-ene-15,16-dial compound or a pharmaceutically acceptable salt thereof having anti-bacterial and anti-cancerous activities which is separated and purified from Zingiber Mioga Roscoe. CONSTITUTION: The Labda-12-ene-15,16-dial compound or the pharmaceutically acceptable salt thereof is represented by the formula 1, and is separated and purified by the method comprising the steps of: drying a flower bud and a rootstalk of Zingiber mioga Roscoe in the shade; extracting the dried flower bud and rootstalk twice for two weeks using methanol; collecting and concentrating each extracts under vacuum; suspending each concentrates in distilled water and fractionizing the suspension with ethyl acetate three times; concentrating the ethyl acetate fraction under vacuum, followed by silica gel column chromatography; and re-crystallizing the column chromatography fraction using ether and hexane.