인간 과립구 콜로니 자극인자의 생물학적 활성 증가 변이체
    2.
    发明公开
    인간 과립구 콜로니 자극인자의 생물학적 활성 증가 변이체 有权
    具有增加的生物活性的突变C-CSF生产

    公开(公告)号:KR1020110078038A

    公开(公告)日:2011-07-07

    申请号:KR1020090134751

    申请日:2009-12-30

    Abstract: PURPOSE: A mutant human G-CSF with increased biological activity is provided to ensure superior biological activity and excellent economic effect with low dosage. CONSTITUTION: A mutant human G-CSF has amino acid modification by N-glycosylateion by formation of Asn-X-Ser/Thr(N-X-S/T) sequence in an amino acid residues: T1-P10 (T1-P-L-Q-P-A-S-S-L-P10); K40-Q70 (K40-L-C-H-P-E-E-L-V-L-L-G-H-S-L-G-I-P-W-A-P-L-S-S-C-P-S-Q-A-L-Q70); or L124-S142 (L124-G-M-A-P-A-L-Q-P-T-Q-G-A-M-P-A-F-A-S142). A pharmaceutical composition contains the mutant human G-CSF.

    Abstract translation: 目的:提供具有增加生物活性的突变型人类G-CSF,以确保优异的生物活性和低剂量的优异的经济效果。 构成:突变型人G-CSF通过在氨基酸残基:T1-P10(T1-P-L-Q-P-A-S-S-L-P10)中形成Asn-X-Ser / Thr(N-X-S / T)序列而进行N-糖基化的氨基酸修饰。 K40-Q70(K40-L-C-H-P-E-E-L-V-L-L-G-H-S-L-G-I-P-W-A-P-L-S-S-C-P-S-Q-A-L-Q70) 或L124-S142(L124-G-M-A-P-A-L-Q-P-T-Q-G-A-M-P-A-F-A-S142)。 药物组合物含有突变型人G-CSF。

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