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公开(公告)号：KR101330033B1
公开(公告)日：2013-11-22
申请号：KR1020100101442
申请日：2010-10-18
Applicant: 대한민국(농촌진흥청장)
Abstract: 본 발명은 인간 과립구 콜로니 자극 인자(G-CSF)의 변이체를 포함하는 허혈성 질환 치료용 약학 조성물에 관한 것으로, 더욱 상세하게는 인간 과립구 콜로니 자극인자(G-CSF)의 아미노산 잔기 140번째 페닐알라닌(Phenylalanine, F)이 아스파라긴 (Asparagine, N)으로 치환되어 당쇄화가 일어나도록 아미노산 변형된 인간 과립구 콜로니 자극 인자(G-CSF)의 변이체를 포함하는 허혈성 질환 치료용 약학 조성물에 관한 것이다.
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公开(公告)号：KR1020110078038A
公开(公告)日：2011-07-07
申请号：KR1020090134751
申请日：2009-12-30
Applicant: 대한민국(농촌진흥청장)
IPC: C07K14/535 , C12N15/27 , C12N15/63 , A61K38/18
Abstract: PURPOSE: A mutant human G-CSF with increased biological activity is provided to ensure superior biological activity and excellent economic effect with low dosage. CONSTITUTION: A mutant human G-CSF has amino acid modification by N-glycosylateion by formation of Asn-X-Ser/Thr(N-X-S/T) sequence in an amino acid residues: T1-P10 (T1-P-L-Q-P-A-S-S-L-P10); K40-Q70 (K40-L-C-H-P-E-E-L-V-L-L-G-H-S-L-G-I-P-W-A-P-L-S-S-C-P-S-Q-A-L-Q70); or L124-S142 (L124-G-M-A-P-A-L-Q-P-T-Q-G-A-M-P-A-F-A-S142). A pharmaceutical composition contains the mutant human G-CSF.
Abstract translation: 目的：提供具有增加生物活性的突变型人类G-CSF，以确保优异的生物活性和低剂量的优异的经济效果。 构成：突变型人G-CSF通过在氨基酸残基：T1-P10（T1-P-L-Q-P-A-S-S-L-P10）中形成Asn-X-Ser / Thr（N-X-S / T）序列而进行N-糖基化的氨基酸修饰。 K40-Q70（K40-L-C-H-P-E-E-L-V-L-L-G-H-S-L-G-I-P-W-A-P-L-S-S-C-P-S-Q-A-L-Q70） 或L124-S142（L124-G-M-A-P-A-L-Q-P-T-Q-G-A-M-P-A-F-A-S142）。 药物组合物含有突变型人G-CSF。
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公开(公告)号：KR101174494B1
公开(公告)日：2012-08-22
申请号：KR1020090134751
申请日：2009-12-30
Applicant: 대한민국(농촌진흥청장)
IPC: C07K14/535 , C12N15/27 , C12N15/63 , A61K38/18
Abstract: 본발명은인간과립구콜로니자극인자의생물학적활성증가변이체에관한것으로서, 더욱상세하게는생리활성단백질의체내혈액중의안정성및 활성을증가시키기위해인간과립구콜로니자극인자의특정부위에 Asn-X-Ser/Thr (N-X-S/T) 서열이하나이상형성되어이 부위에서당쇄화가일어나도록아미노산이변형된인간과립구콜로니자극인자(G-CSF)의변이체및 당쇄화된인간과립구콜로니자극인자에관한것이다.
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Patent Agency Ranking
公开(公告)号：KR1020010039135A
公开(公告)日：2001-05-15
申请号：KR1019990047397
申请日：1999-10-29
Applicant: 대한민국(농촌진흥청장)
IPC: C02F3/12
CPC classification number: Y02W10/15
Abstract: PURPOSE: An apparatus for separating fine solids for reducing contaminants of wastewater is provided in which wastewater bearing organic materials including various animal excretions, animal and plant residues, etc. can be composted without using moisture controlling agents. CONSTITUTION: The apparatus comprises an excrementitious slurry supplying pipe (32) installed at the upper part of the one side of an aeration tank (30) for supplying the slurry according to the control of an excrementitious slurry supply control part (31); an air supply control part (34) connected to an air supplying passage (33) located at the water bottom part of the aeration tank; a screw type auger (35) installed from the lower part of the aeration tank to over the surface of the wastewater and equipped with a solid discharging hole (36); an ultra-low speed reduction unit (37) installed at the end part of the screw type auger for blocking a slurry counterflow; an inlet pipe (41) installed from the upper part of the aeration tank to the lower part of a settling tank (40) so that the floating liquid passing through the aeration process at the aeration tank is flown into the settling tank; a reverse osmosis membrane forming part (42) installed by being floated on the upper part of the settling tank; a return pipe (43) connected to a power return part (44) at the lower part of the settling tank for returning a sediment of the settling tank to the aeration tank; and a water treatment system connecting pipe (45) installed at the upper part of the one side of the settling tank for guiding the floating liquid passing through the reverse osmosis membrane forming part to a water treatment system (50) by a transferring power part (46).
Abstract translation: 目的：提供一种用于分离细小固体以减少废水污染物的设备，其中含有各种动物排泄物，动物和植物残留物等的有机废物可以在不使用水分控制剂的情况下进行堆肥。 构成：该装置包括安置在曝气池（30）的一侧上部的排泄性浆料供给管（32），用于根据排泄物浆料供给控制部（31）的控制供给浆料; 连接到位于曝气池的水底部的空气供给通道（33）的空气供给控制部（34） 螺旋式螺旋推运器（35），其从所述曝气池的下部安装到所述废水的表面上并且具有固体排放孔（36）; 一个安装在螺旋式螺旋钻末端的超低速减速装置（37），用于阻塞泥浆逆流; 从曝气池的上部安装到沉淀池（40）的下部的入口管（41），使得通过曝气池的曝气处理的浮动液体流入沉降槽; 反渗透膜形成部件（42）通过悬浮在沉淀池的上部而被安装; 连接到沉淀池下部的动力返回部分（44）的返回管（43），用于将沉降池的沉淀物返回到曝气池; 以及安装在沉淀池一侧上部的水处理系统连接管（45），用于将通过反渗透膜形成部分的浮动液体通过传递力部分引导到水处理系统（50） 46）。
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公开(公告)号：KR100433268B1
公开(公告)日：2004-05-31
申请号：KR1020000058513
申请日：2000-10-05
Applicant: 대한민국(농촌진흥청장)
IPC: C12N1/00
Abstract: PURPOSE: Provided are a microbial composition of a fermenting agent for the bioremediation of malodorants and its manufacturing method. The microbial composition further contains feed additives, such as copper, rice bran and zeolite, to increase a deodorizing effect. CONSTITUTION: The microbial composition of a fermenting agent for the bioremediation of malodorants comprises at least one of Aspergillus niger, Aspergillus oryzae, Penicillium spp., Mucor spp., Trichoderma viride, Cephallosporium acremonium and Issatchenkia orientalis; at least one of Candida spp., and Arthrobacter spp., Nocardia spp.; at least one of Bacillus subtilis CH-10, Bacillus mesentericus, Bacillus megaterium, Bacillus licheniformis NLRI-33, Bacillus thuringiensis, and bacillus circulans; at least one of Thermoactinomyces sp. and/or Thermomonspora spp.; at least one of Streptomyces griseus, Streptomyces globisporius, and Streptomyces flavus; and at least one of Pseudomonas putida NLRI-X50, Corynebacterium spp., Staphylococcus lentus, and Micrococcus lylae.
Abstract translation: 用途：提供用于恶臭物质生物修复的发酵剂的微生物组合物及其制造方法。 为了提高除臭效果，微生物组合物还含有铜，米糠，沸石等饲料添加物。 组成：用于恶臭物质生物修复的发酵剂的微生物组合物包含黑曲霉，米曲霉，青霉属，毛霉属，绿色木霉，顶头孢霉和东方伊萨酵母中的至少一种; 至少一种假丝酵母属和节杆菌属，诺卡氏菌属; 枯草芽孢杆菌CH-10，肠杆菌，巨大芽孢杆菌，地衣芽孢杆菌NLRI-33，苏云金芽孢杆菌和环状芽孢杆菌中的至少一种; 至少一种热放线菌属物种。 和/或Thermomonspora spp。 至少一种灰色链霉菌，球状链霉菌和黄色链霉菌; 以及恶臭假单胞菌NLRI-X50，棒状杆菌属，迟缓葡萄球菌和微球菌属中的至少一种。
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公开(公告)号：KR100365481B1
公开(公告)日：2002-12-26
申请号：KR1019990047397
申请日：1999-10-29
Applicant: 대한민국(농촌진흥청장)
IPC: C02F3/12
CPC classification number: Y02W10/15
Abstract: 본발명은각 하부가원뿔또는다각뿔형태인폭기조(30)와침전조(40)가연결도관들에의해연결구성되는폐수의미세고형물분리장치에있어서, 상기폭기조(30)의일측상단에설치되어분뇨슬러지공급조절부(31)의조절에따라슬러지를공급하는분뇨슬러지공급도관(32)과; 상기폭기조(30)의수저부에위치한공기공급로(33)와연결설치되는공기공급조절부(34)와; 상기폭기조(30)의하부에서폐수면위로설치되며고형물배출구(36)를구비한스크류형오가(35)와; 상기스크류형오가(35)의말단에설치되어슬러지역류를차단하는초저속감속장치(37)와; 상기폭기조(30)에서폭기과정을거친부유액상이침전조(40)로유입되도록폭기조(30) 상부에서침전조(40) 하부에걸쳐설치되는유입도관(41)과; 상기침전조(40)의상부에띄워설치되는역삼투막형성부(42)와; 상기침전조(40) 하부에동력반송부(44)와연결설치되어침전조(40)의침전물을폭기조(30)로환원시키는반송도관(43)과; 상기침전조(40)의일측상단에설치되어역삼투막형성부(42)를통과한부유액상을이송동력부(46)에의해수처리시스템(50)으로유도하는수처리시스템연계도관(45)으로구성되는, 폐수오염물질저감용미세고형물분리장치에관한것으로서, 미세고형물까지분리해낼 수있기때문에수질오염을줄이는데크게기여할수 있으며, 수분조절재투여없이배출된고형물을퇴비화할수 있다.
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公开(公告)号：KR1020020027818A
公开(公告)日：2002-04-15
申请号：KR1020000058513
申请日：2000-10-05
Applicant: 대한민국(농촌진흥청장)
IPC: C12N1/00
Abstract: PURPOSE: Provided are a microbial composition of a fermenting agent for the bioremediation of malodorants and its manufacturing method. The microbial composition further contains feed additives, such as copper, rice bran and zeolite, to increase a deodorizing effect. CONSTITUTION: The microbial composition of a fermenting agent for the bioremediation of malodorants comprises at least one of Aspergillus niger, Aspergillus oryzae, Penicillium spp., Mucor spp., Trichoderma viride, Cephallosporium acremonium and Issatchenkia orientalis; at least one of Candida spp., and Arthrobacter spp., Nocardia spp.; at least one of Bacillus subtilis CH-10, Bacillus mesentericus, Bacillus megaterium, Bacillus licheniformis NLRI-33, Bacillus thuringiensis, and bacillus circulans; at least one of Thermoactinomyces sp. and/or Thermomonspora spp.; at least one of Streptomyces griseus, Streptomyces globisporius, and Streptomyces flavus; and at least one of Pseudomonas putida NLRI-X50, Corynebacterium spp., Staphylococcus lentus, and Micrococcus lylae.
Abstract translation: 目的：提供用于恶臭生物除菌的发酵剂的微生物组合物及其制备方法。 微生物组合物还含有饲料添加剂，例如铜，米糠和沸石，以增加除臭效果。 构成：用于恶臭生物修复的发酵剂的微生物组成包括黑曲霉，米曲霉，青霉属，毛霉属，绿色木霉，顶头孢霉和东方伊斯兰肯氏菌中的至少一种; 至少一种念珠菌属和节杆菌属，诺卡氏菌属（Nocardia spp。）。 枯草芽孢杆菌CH-10，肠系膜菌芽孢杆菌，巨球芽孢杆菌，地衣芽孢杆菌NLRI-33，苏云金芽孢杆菌和环状芽孢杆菌中的至少一种; 至少一种热乳杆菌属 和/或Thermomonspora spp。 灰绿链霉菌，全球链球菌和黄曲霉链霉菌中的至少一种; 以及恶臭假单胞菌NLRI-X50，棒状杆菌属（Corynebacterium spp。），葡萄球菌（Staphylococcus lentus）和微球菌（Micrococcus lylae）中的至少一种。
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公开(公告)号：KR1020120047338A
公开(公告)日：2012-05-14
申请号：KR1020100101442
申请日：2010-10-18
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K38/193 , C07K14/535 , Y10S514/824
Abstract: PURPOSE: A pharmaceutical composition containing human G-CSF mutant is provided to reduce administration amount and number. CONSTITUTION: A pharmaceutical composition for treating ischemic diseases contains the G-CSF mutant which is modified by substitution of 140th amino acid residue of human G-CSF, from phenylalanine(F) to asparagine(N). The human G-CSF is G-CSFb. The pharmaceutical composition further contains a carrier or excipient. The pharmaceutical composition also contains suspension, stabilizing agent, isotonizing agent, preservative, anti-adsorbing agent, surfactant, pH adjusting agent, analgesia agent, or anti-oxidant agent.
Abstract translation: 目的：提供含有人G-CSF突变体的药物组合物，以减少给药量和数量。 构成：用于治疗缺血性疾病的药物组合物含有通过将人G-CSF的第140位氨基酸残基从苯丙氨酸（F）取代为天冬酰胺（N）而被修饰的G-CSF突变体。 人G-CSF是G-CSFb。 药物组合物还含有载体或赋形剂。 药物组合物还含有悬浮液，稳定剂，等渗剂，防腐剂，抗吸附剂，表面活性剂，pH调节剂，镇痛剂或抗氧化剂。
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