公开(公告)号：KR100441202B1

公开(公告)日：2004-07-23

申请号：KR1020010078140

申请日：2001-12-11

Applicant: 대한민국 (식품의약품안전처장)

Inventor： 조정식 ,  채갑용 ,  김용규 ,  임철주 ,  신동환 ,  장인석 ,  황진희 ,  황대연 ,  조용연 ,  김연주 ,  백상기

IPC: A01K67/00

Abstract: PURPOSE: Provided is a transformed mouse expressing the HPV E6 gene which is usefully used in screening tumor gene and tumor treating agent since tumor development occurs at the late stage. CONSTITUTION: An animal excluding human beings is transformed to express HPV(human papilloma virus) E6 gene inducing the mammary gland tumor. In the transformed animal, the HPV E6 gene is inserted into the chromosome of the animal and is operably linked to a beta-casein promotor. The chromosome is able to be body cells or sexual cells. The animal is mainly a mouse.

Abstract translation: 目的：提供一种表达HPV E6基因的转化的小鼠，由于在晚期发生肿瘤基因和肿瘤治疗剂，所以它被有效地用于筛选肿瘤基因和肿瘤治疗剂。 构成：将除人以外的动物转化为表达诱导乳腺肿瘤的HPV（人乳头状瘤病毒）E6基因。 在转化的动物中，将HPV E6基因插入动物的染色体并可操作地连接至β-酪蛋白启动子。 染色体可以是身体细胞或有性细胞。 该动物主要是一只老鼠。

公开(公告)号：KR1020030048253A

公开(公告)日：2003-06-19

申请号：KR1020010078140

申请日：2001-12-11

Applicant: 대한민국 (식품의약품안전처장)

Inventor： 조정식 ,  채갑용 ,  김용규 ,  임철주 ,  신동환 ,  장인석 ,  황진희 ,  황대연 ,  조용연 ,  김연주 ,  백상기

IPC: A01K67/00

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0318 ,  C12N15/8509

Abstract: PURPOSE: Provided is a transformed mouse expressing the HPV E6 gene which is usefully used in screening tumor gene and tumor treating agent since tumor development occurs at the late stage. CONSTITUTION: An animal excluding human beings is transformed to express HPV(human papilloma virus) E6 gene inducing the mammary gland tumor. In the transformed animal, the HPV E6 gene is inserted into the chromosome of the animal and is operably linked to a beta-casein promotor. The chromosome is able to be body cells or sexual cells. The animal is mainly a mouse.

Abstract translation: 目的：提供表达HPV E6基因的转化小鼠，其可用于筛选肿瘤基因和肿瘤治疗剂，因为肿瘤发生在晚期发生。 构成：不包括人类的动物被转化以表达诱导乳腺肿瘤的HPV（人乳头瘤病毒）E6基因。 在转化的动物中，将HPV E6基因插入到动物的染色体中，并可操作地连接到β-酪蛋白启动子。 染色体能够是身体细胞或性细胞。 动物主要是一只老鼠。