公开(公告)号：KR100309888B1

公开(公告)日：2001-11-01

申请号：KR1019990031532

申请日：1999-07-31

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  김종우 ,  한재진 ,  우제태 ,  케이지하수미 ,  나가이카즈오

IPC: A61K38/15

Abstract: 본발명은데스트룩신(destruxin) 유도체를유효성분으로함유하는골다공증예방및 치료제조성물에관한것으로본 발명곰팡이유래의사이클로뎁시펩타이드(cyclodepsipeptide)는파골세포에서부갑상선호르몬(PTH)의존재와관계없이파골세포활성저해능이매우뛰어난효과가있다.

公开(公告)号：KR1020010011926A

公开(公告)日：2001-02-15

申请号：KR1019990031532

申请日：1999-07-31

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  김종우 ,  한재진 ,  우제태 ,  케이지하수미 ,  나가이카즈오

IPC: A61K38/15

Abstract: PURPOSE: A composition containing destruxin derivatives for prevention and treatment of osteoporosis is provided, inwhich cyclodepsipeptide derived from fungi shows excellent osteoclast activity-inhibition effect regardless of presence of PTH(parathyroid hormone) in osteoclast, therefore being used for prevention and treatment of osteoporosis. CONSTITUTION: The various destruxin derivatives can be prepared by a well known method, which is cyclodepsipeptides separated from various fungi(e.g., Metarhizium anisopliae). The composition containing destruxin derivatives for prevention and treatment of osteoporosis can be prepared in the form of tablets, capsules, troches, solution, suspension, or injections, dried powder for injection, a spray, suppositories, or a patch preparation by mixing with pharmaceutically acceptable carriers, and which can be administrated by oral path and parenteral path(e.g., in vein, under subcutaneous, abdominal cavity, or nasal cavity). The composition containing destruxin derivatives can be also administrated in the dosage of 0.1μg-100mg, desirably 100μg-1mg per day.

Abstract translation: 目的：提供含有用于预防和治疗骨质疏松症的destruxin衍生物的组合物，其中来自真菌的环缩酚肽显示出破骨细胞中存在PTH（甲状旁腺激素）的极好的破骨细胞活性抑制作用，因此用于预防和治疗骨质疏松症。 构成：各种destruxin衍生物可以通过众所周知的方法制备，该方法是从各种真菌（例如，Metarhizium anisopliae）分离的环糊精肽。 含有用于预防和治疗骨质疏松症的destruxin衍生物的组合物可以以片剂，胶囊剂，锭剂，溶液，悬浮液或注射剂的形式，注射用干燥粉末，喷雾剂，栓剂或贴剂制剂的形式制备， 载体，并且其可以通过口服途径和肠胃外途径施用（例如，在静脉，皮下，腹腔或鼻腔）。 含有destruxin衍生物的组合物也可以以0.1μg-100mg，优选每天100μg-1mg的剂量施用。