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Patent Agency Ranking
公开(公告)号：KR100278361B1
公开(公告)日：2001-01-15
申请号：KR1019970058896
申请日：1997-11-08
Applicant: 동화약품주식회사
IPC: A61K31/35 , A61K36/484
Abstract: 본 발명은 골다공증 예방 및 치료용 약제 조성물에 관한 것으로서, 더욱 상세하게는 다음 화학식 1로 표시되는 글라브롤, 감초(Glycyrrhiza glabra) 추출물 또는 감초(Glycyrrhiza glabra) 분획물이 유효성분으로 함유되어 있어 골다공증 예방 및 치료에 유용한 약제 조성물에 관한 것이다.
[화학식 1]-
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公开(公告)号：KR1020010011926A
公开(公告)日：2001-02-15
申请号：KR1019990031532
申请日：1999-07-31
Applicant: 동화약품주식회사
IPC: A61K38/15
Abstract: PURPOSE: A composition containing destruxin derivatives for prevention and treatment of osteoporosis is provided, inwhich cyclodepsipeptide derived from fungi shows excellent osteoclast activity-inhibition effect regardless of presence of PTH(parathyroid hormone) in osteoclast, therefore being used for prevention and treatment of osteoporosis. CONSTITUTION: The various destruxin derivatives can be prepared by a well known method, which is cyclodepsipeptides separated from various fungi(e.g., Metarhizium anisopliae). The composition containing destruxin derivatives for prevention and treatment of osteoporosis can be prepared in the form of tablets, capsules, troches, solution, suspension, or injections, dried powder for injection, a spray, suppositories, or a patch preparation by mixing with pharmaceutically acceptable carriers, and which can be administrated by oral path and parenteral path(e.g., in vein, under subcutaneous, abdominal cavity, or nasal cavity). The composition containing destruxin derivatives can be also administrated in the dosage of 0.1μg-100mg, desirably 100μg-1mg per day.
Abstract translation: 目的：提供含有用于预防和治疗骨质疏松症的destruxin衍生物的组合物，其中来自真菌的环缩酚肽显示出破骨细胞中存在PTH（甲状旁腺激素）的极好的破骨细胞活性抑制作用，因此用于预防和治疗骨质疏松症。 构成：各种destruxin衍生物可以通过众所周知的方法制备，该方法是从各种真菌（例如，Metarhizium anisopliae）分离的环糊精肽。 含有用于预防和治疗骨质疏松症的destruxin衍生物的组合物可以以片剂，胶囊剂，锭剂，溶液，悬浮液或注射剂的形式，注射用干燥粉末，喷雾剂，栓剂或贴剂制剂的形式制备， 载体，并且其可以通过口服途径和肠胃外途径施用（例如，在静脉，皮下，腹腔或鼻腔）。 含有destruxin衍生物的组合物也可以以0.1μg-100mg，优选每天100μg-1mg的剂量施用。
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公开(公告)号：KR1019990038984A
公开(公告)日：1999-06-05
申请号：KR1019970058896
申请日：1997-11-08
Applicant: 동화약품주식회사
IPC: A61K31/35 , A61K36/484
Abstract: 본 발명은 골다공증 예방 및 치료용 약제 조성물에 관한 것으로서, 더욱 상세하게는 다음 화학식 1로 표시되는 글라브롤, 감초(Glycyrrhiza glabra) 추출물 또는 감초(Glycyrrhiza glabra) 분획물이 유효성분으로 함유되어 있어 골다공증 예방 및 치료에 유용한 약제 조성물에 관한 것이다.
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公开(公告)号：KR1020030002377A
公开(公告)日：2003-01-09
申请号：KR1020010037947
申请日：2001-06-29
Applicant: 동화약품주식회사
IPC: A61K36/8962 , A61P3/14
Abstract: PURPOSE: A pharmaceutical composition for prophylaxis and treatment of osteoporosis containing an extract of onion or kale, quercetin or rutin as an effective ingredient is provided. The quercetin or rutin has the excellent function of inhibiting differentiation of osteoclast, is low in cost and has no adverse effect, it can be thus effectively used in the prevention and treatment of osteoporosis. CONSTITUTION: The pharmaceutical composition for prophylaxis and treatment of osteoporosis contains an extract obtained by extracting one of onion and kale in methanol, quercetin represented by formula(1) or rutin represented by formula(2). For an example, onion and kale are extracted in methanol at 80deg.C for 3hr, filtered and washed two times after cooling. The extract is cultured with 200μl osteoclast solution at 37deg.C under 5% CO2 for 1 to 2 day and shows a high inhibition rate of osteoclast.
Abstract translation: 目的：提供一种用于预防和治疗含有洋葱或羽衣甘蓝，槲皮素或芦丁提取物作为有效成分的骨质疏松症的药物组合物。 槲皮素或芦丁具有抑制破骨细胞分化的优异功能，成本低，无副作用，可有效用于预防和治疗骨质疏松症。 构成：用于预防和治疗骨质疏松症的药物组合物含有通过在甲醇中提取洋葱和羽衣甘蓝而获得的提取物，由式（1）表示的槲皮素或由式（2）表示的芦丁。 例如，洋葱和羽衣甘蓝在80℃的甲醇中萃取3小时，冷却后过滤并洗涤两次。 提取物在37℃，5％CO 2下，用200μl破骨细胞溶液培养1〜2天，破骨细胞抑制率高。
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