Abstract:
본 발명은 필발(Piper Longum L.) 추출물을 유효성분으로 포함하는 배뇨 장애 예방 또는 치료용 약학적 조성물 및 배뇨 장애 예방 또는 개선용 건강기능식품에 관한 것이다. 본 발명의 필발 추출물은 천연 추출물로 인체에 무해할 뿐만 아니라 배뇨 장애에 관여하는 다양한 기전에 동시에 관여함으로써 배뇨 간격을 증가시키고, 배뇨압을 감소시키고 방광의 용적을 증가시키며, 배뇨근의 수축을 억제하고 배뇨근의 이완을 유도할 수 있으므로, 다양한 배뇨 장애를 예방, 치료 또는 개선하는 효과가 우수하다.
Abstract:
PURPOSE: A lipid improving agent for prevention and treating hyperlipidemia which contains solvent fraction of caryophylli flos ethanol extracts is provided to enhance ACAT enzyme inhibition effects. CONSTITUTION: A lipid improving agent for prevention and treating hyperlipidemia contains Caryophylli Flos ethylacetate fraction as an active ingredient. The Caryophylli Flos ethylacetate fraction is obtained by the following steps: extracting the Caryophylli Flos as ethanol at the room temperature and concentrating at 60 deg. Or less and suspends in water; solvent extracting the suspended solution using hexane and removing the separated hexane layer; solvent extracting the remaining water layer by using the methylene chloride solvent and isolating and removing the methylenechloride layer; isolation extracting the remaining water layer by using ethylacetate solvent and separating the ethylacetate layer and compressing and concentrating thereof at 60 deg. Celsius or less. [Reference numerals] (AA) Caryophylli flos; (BB) 95% ethanol; (CC) Caryophylli flos 95% ethanol extract(comparative example 1); (DD) Water; (EE) Suspended solution; (FF) Hexane; (GG) Hexane layer(comparative example 2); (HH, KK, NN) Water layer; (II) Methylenechloride; (JJ) Methylenechloride layer(comparative example 3); (LL) Ethyl acetate; (MM) Ethyl acetate layer(practical example 1); (OO) Butanol; (PP) Butanol layer(comparative example 4); (QQ) Water layer(comparative example 5)