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    감수에서 분리된 테르페노이드 또는 이를 포함하는감수추출물을 함유하는 골다공증 예방 및 치료용 약학조성물
    1.
    发明公开
    감수에서 분리된 테르페노이드 또는 이를 포함하는감수추출물을 함유하는 골다공증 예방 및 치료용 약학조성물 失效
    用于预防和治愈包含两种泰乐菌素，分离物或提取物的化学成分的组合物

    公开(公告)号：KR1020070081294A

    公开(公告)日：2007-08-16

    申请号：KR1020060013167

    申请日：2006-02-10

    Applicant: 동화약품주식회사

    Inventor： 유제만 ,  임문정 ,  노양국 ,  오성준 ,  이현용 ,  장환봉 ,  황연하 ,  이정욱

    IPC: A61K31/341 ,  A61K31/56 ,  A61K36/47 ,  A61P19/10

    Abstract: A composition for preventing and treating osteoporosis comprising terpenoids isolated from Euphorbia kansui or the extracts thereof is provided to inhibit bone absorption of osteoclasts without side effects. The composition for preventing and treating osteoporosis comprises kansuinine A represented by the formula(1) and gamma-euphorbol represented by the formula(2) or the extracts thereof. The kansuinine A represented by the formula(1) and gamma-euphorbol represented by the formula(2) are isolated by extracting and concentrating Euphorbia kansui with methanol, suspending the concentrated extract of Euphorbia kansui in water, and adding nucleic acid into the suspension to separate a nucleic acid layer, adding methylene chloride into a water layer obtained by separating the nucleic acid layer to obtain a methylene chloride fraction, and subjecting the methylene chloride fraction to chromatography.

    Abstract translation: 提供了用于预防和治疗包括从大戟属分离的萜类化合物或其提取物的骨质疏松症的组合物，以抑制破骨细胞的骨吸收而没有副作用。 用于预防和治疗骨质疏松症的组合物包括由式（1）表示的苦参碱A和由式（2）表示的γ-高效药或其提取物。 由式（1）表示的甘露宁A和由式（2）表示的γ-高效酚通过用甲醇萃取浓缩大戟甘油，将浓缩的大戟属浓缩提取物悬浮于水中，并将核酸加入到悬浮液中 分离核酸层，将二氯甲烷加入到通过分离核酸层获得的水层中，得到二氯甲烷部分，并将二氯甲烷部分进行色谱分离。

    정향 에탄올 추출물의 용매 분획물을 유효성분으로 함유하는 고지혈증 예방 및 치료용 지질개선제
    3.
    发明公开
    정향 에탄올 추출물의 용매 분획물을 유효성분으로 함유하는 고지혈증 예방 및 치료용 지질개선제 无效
    预防高脂血症和固化脂质体改良剂含有溶血性脂肪分解物的提取物

    公开(公告)号：KR1020120114790A

    公开(公告)日：2012-10-17

    申请号：KR1020110032546

    申请日：2011-04-08

    Applicant: 동화약품주식회사

    Inventor： 이진수 ,  성승규 ,  노양국 ,  염지현 ,  오성준 ,  이창준 ,  박다애 ,  장환봉

    IPC: A61K36/61 ,  A61P3/06 ,  A61P3/00

    CPC classification number: A61K36/61 ,  A23V2200/326 ,  A23V2200/3262 ,  A61K2236/33

    Abstract: PURPOSE: A lipid improving agent for prevention and treating hyperlipidemia which contains solvent fraction of caryophylli flos ethanol extracts is provided to enhance ACAT enzyme inhibition effects. CONSTITUTION: A lipid improving agent for prevention and treating hyperlipidemia contains Caryophylli Flos ethylacetate fraction as an active ingredient. The Caryophylli Flos ethylacetate fraction is obtained by the following steps: extracting the Caryophylli Flos as ethanol at the room temperature and concentrating at 60 deg. Or less and suspends in water; solvent extracting the suspended solution using hexane and removing the separated hexane layer; solvent extracting the remaining water layer by using the methylene chloride solvent and isolating and removing the methylenechloride layer; isolation extracting the remaining water layer by using ethylacetate solvent and separating the ethylacetate layer and compressing and concentrating thereof at 60 deg. Celsius or less. [Reference numerals] (AA) Caryophylli flos; (BB) 95% ethanol; (CC) Caryophylli flos 95% ethanol extract(comparative example 1); (DD) Water; (EE) Suspended solution; (FF) Hexane; (GG) Hexane layer(comparative example 2); (HH, KK, NN) Water layer; (II) Methylenechloride; (JJ) Methylenechloride layer(comparative example 3); (LL) Ethyl acetate; (MM) Ethyl acetate layer(practical example 1); (OO) Butanol; (PP) Butanol layer(comparative example 4); (QQ) Water layer(comparative example 5)

    Abstract translation: 目的：提供一种用于预防和治疗含有caryophylli flos乙醇提取物的溶剂级分的高脂血症的脂质改善剂，以增强ACAT酶的抑制作用。 构成：用于预防和治疗高脂血症的脂质改善剂含有Caryophylli Flos乙酸乙酯部分作为活性成分。 通过以下步骤获得Caryophylli Flos乙酸乙酯级分：在室温下将Caryophylli Flos作为乙醇提取，并在60℃浓缩。 或更少，并在水中暂停; 溶剂用己烷萃取悬浮溶液，除去分离的己烷层; 溶剂通过使用二氯甲烷溶剂萃取剩余的水层并分离和除去二氯甲烷层; 通过使用乙酸乙酯溶剂分离萃取剩余的水层并分离乙酸乙酯层并在60℃压缩并浓缩。 摄氏度以下。 （附图标记）（AA）Caryophylli flos; （BB）95％乙醇; （CC）Caryophylli flos 95％乙醇提取物（比较例1）; （DD）水; （EE）悬浮溶液; （FF）己烷; （GG）己烷层（比较例2）。 （HH，KK，NN）水层; （二）亚甲基氯; （JJ）亚甲基氯化物层（比较例3）; （LL）乙酸乙酯; （MM）乙酸乙酯层（实施例1）; （OO）丁醇; （PP）丁醇层（比较例4）; （QQ）水层（比较例5）

    상백피에서 단리된 화합물의 용도
    7.
    发明公开
    상백피에서 단리된 화합물의 용도 审中-实审
    使用从MORUS BARK分离的化合物

    公开(公告)号：KR1020140123264A

    公开(公告)日：2014-10-22

    申请号：KR1020130040342

    申请日：2013-04-12

    Applicant: 동화약품주식회사

    Inventor： 장환봉 ,  윤주병 ,  이현용 ,  노양국

    IPC: A61K31/05 ,  A61K31/045 ,  A61K36/605 ,  A61P3/10

    CPC classification number: A61K36/605 ,  A23L33/105 ,  A61K31/352

    Abstract: The present invention relates to a pharmaceutical composition or health functional food comprising cathayanin B or kuwanol A, which are compounds isolated from morus bark, for preventing and treating diabetic complications. According to the present invention, the cathayanin B compound is isolated from the morus bark, and inhibits the creation of an advanced glycation end-product (AGE), which is a causative substance of diabetic complications, and aldose reductase activity. Thus, the pharmaceutical composition or health functional food, which comprises the cathayanin B or the kuwanol A, can be useful for inhibiting diabetic complications such as diabetic nephropathy, diabetic retinopathy and diabetic neuropathy. In particular, the kuwanol A can be used as the pharmaceutical composition for preventing and treating various fibrosis and cancer metastasis as well as the diabetic complications and also used as the health functional food for alleviating the same.

    Abstract translation: 本发明涉及一种药物组合物或保健功能食品，其包含作为从桑树皮分离的化合物，用于预防和治疗糖尿病并发症的cathayanin B或kuwanol A。 根据本发明，从桑树皮中分离出cathayanin B化合物，抑制作为糖尿病并发症的致病物质的高级糖基化终产物（AGE）的产生和醛糖还原酶的活性。 因此，包含cathayanin B或kuwanol A的药物组合物或健康功能性食品可用于抑制糖尿病性肾病，糖尿病性视网膜病变和糖尿病性神经病变等糖尿病并发症。 特别地，可以将奎娃子A用作预防和治疗各种纤维化和癌症转移以及糖尿病并发症的药物组合物，并且也用作用于缓解其的健康功能性食品。

    플라보노이드 계열 화합물 또는 이를 포함하는 강진향추출물을 함유한 매트릭스 메탈로프로테이나제 활성저해제 및 기능성 식품
    10.
    发明公开
    플라보노이드 계열 화합물 또는 이를 포함하는 강진향추출물을 함유한 매트릭스 메탈로프로테이나제 활성저해제 및 기능성 식품 失效
    基质金属蛋白酶抑制剂和含有FLAVONOID衍生物的功能性食品或含有黄酮衍生物的DALBERGIA ODORIFERA的提取物

    公开(公告)号：KR1020030075396A

    公开(公告)日：2003-09-26

    申请号：KR1020020014588

    申请日：2002-03-18

    Applicant: 동화약품주식회사 ,  이승택

    Inventor： 이승택 ,  장진욱 ,  김주현 ,  장윤정 ,  정용호 ,  임문정 ,  성희진 ,  노양국 ,  신동혁 ,  장환봉

    IPC: C07D311/40

    Abstract: PURPOSE: A matrix metalloproteinase inhibitor and functional food containing flavonoid derivatives or extracts of Dalbergia odorifera containing the flavonoid derivatives are provided, thereby effectively treating diseases associated with matrix metalloproteinase. CONSTITUTION: Extracts of Dalbergia odorifera containing fisetin of formula 1 and 3'-hydroxydidzein of formula 2 are prepared by dissolving pulverized Dalbergia odorifera in a solvent selected from methanol, a mixed solvent of methanol and water and ethylacetate, filtering the solution, and concentrating the filtered solution under reduced pressure. A fraction of Dalbergia odorifera containing fisetin and 3'-hydroxydidzein is prepared by dissolving Dalbergia odorifera in methanol or a mixed solvent of water and methanol, filtering the solution, adding ethylacetate or butanol into the filtered solution, filtering the solution, and concentrating the filtered solution under reduced pressure.

    Abstract translation: 目的：提供一种基质金属蛋白酶抑制剂和含有黄酮类衍生物的黄酮类衍生物或含有黄酮衍生物的提取物的功能性食品，从而有效治疗与基质金属蛋白酶相关的疾病。 构成：通过将粉碎的Dalbergia odorifera溶解在选自甲醇，甲醇和水与乙酸乙酯的混合溶剂的溶剂中，过滤该溶液并浓缩，得到含有式1的非瑟酮和式2的3'-氢氧根霉素的Dalbergia odorifera的提取物 在减压下过滤溶液。 通过将Dalbergia odorifera在甲醇或水和甲醇的混合溶剂中溶解，过滤该溶液，向过滤的溶液中加入乙酸乙酯或丁醇，过滤溶液，浓缩过滤的溶液，制备含有非丝氨酸和3'-羟基溶解素的Dalbergia odorifera的一小部分 溶液在减压下。

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