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公开(公告)号：KR1020110037530A
公开(公告)日：2011-04-13
申请号：KR1020090095015
申请日：2009-10-07
Applicant: 서울대학교산학협력단
CPC classification number: C12P19/04 , C12P2201/00
Abstract: PURPOSE: A method for improving enzyme hydrolysis of a biomass by organic solvent pretreatment is provided to enhance hydrolysate yield. CONSTITUTION: A method for improving enzyme hydrolysis of a biomass by organic solvent pretreatment comprises: a step of pretreating ligneous biomass with an organic solvent for 10 minutes and a step of performing enzyme hydrolysis. The ligneous biomass is lignin.
Abstract translation: 目的：提高通过有机溶剂预处理改善生物质酶水解的方法，以提高水解产率。 构成：通过有机溶剂预处理来改善生物质的酶水解的方法包括：用有机溶剂预处理木质生物质10分钟的步骤和进行酶水解的步骤。 木质生物质是木质素。
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公开(公告)号：KR1020120099904A
公开(公告)日：2012-09-12
申请号：KR1020110018414
申请日：2011-03-02
Applicant: 서울대학교산학협력단
CPC classification number: C07K7/06 , A61K38/08 , A61K47/66 , G01N33/57407
Abstract: PURPOSE: A malignant undifferentiated cancer stem cell target peptide is provided to effectively and accurately deliver anti-cancer drug to tumor cells by targeting nestin-positive cells of tumor cells. CONSTITUTION: A malignant undifferentiated cancer stem cell target peptide GICT has AQYLNPS sequence which can selectively recognizes and combines with the malignant undifferentiated tumor stem cells. A marker for diagnosing malignant cancers uses the cancer stem cell target peptide GICT having AQYLNPS sequence. A method for screening the cancer stem cell target peptide, which can selectively recognize and combine with the malignant undifferentiated cancer stem cells, uses phage display technique. The method for sorting and inspecting the cancer stem cell target peptide comprises the following steps: prying the cancer stem cell target peptides through sorting the cancer stem cell bonded phage and analyzing the individual phage combination aspect by using the page display technique; analyzing combining ability of the pried cancer stem cell target peptide with the various cells; sorting and verifying the protein bonded with the pried cancer stem cell target peptide; verifying the cancer tissue transmission ability of the cancer stem cell target peptide in a cancer model mouse; verifying undifferentiated cancer stem cell specific targeting ability of the cancer stem cell target peptide in the brain tumor organization; and confirming the cancer cell growth inhibition ability in the tumor model mouse of the tumor stem cell target peptide.
Abstract translation: 目的：通过靶向肿瘤细胞的巢蛋白阳性细胞，提供恶性未分化癌症干细胞靶肽，以有效和准确地将抗癌药物递送至肿瘤细胞。 构成：恶性未分化癌症干细胞靶肽GICT具有AQYLNPS序列，可以选择性识别和与恶性未分化肿瘤干细胞结合。 用于诊断恶性肿瘤的标记物使用具有AQYLNPS序列的癌干细胞靶肽GICT。 筛选可以选择性识别和与恶性未分化癌细胞结合的癌干细胞靶肽的方法，使用噬菌体展示技术。 癌症干细胞靶肽分选检测方法包括以下步骤：通过分选癌干细胞粘附的噬菌体，通过使用页面显示技术分析单个噬菌体组合方面，来窥探癌症干细胞靶肽; 分析pri癌干细胞靶肽与各种细胞的结合能力; 分选和验证与脯氨酸癌干细胞靶肽结合的蛋白质; 验证癌症模型小鼠中癌干细胞靶肽的癌组织传播能力; 验证癌症干细胞靶肽在脑肿瘤组织中的未分化癌干细胞特异性靶向能力; 并确认肿瘤干细胞靶肽的肿瘤模型小鼠中的癌细胞生长抑制能力。
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Patent Agency Ranking
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公开(公告)号：KR1020140019261A
公开(公告)日：2014-02-14
申请号：KR1020130159707
申请日：2013-12-19
Applicant: 서울대학교산학협력단
Abstract: The present invention relates to tumor stem cell targeting peptide GICT which can selectively recognize and bind malignant undifferentiated brain tumor stem cells, and a diagnosis method of brain tumor using the peptide. The present invention provides a pharmaceutical composition for preventing and treating malignant tumor which contains the tumor stem cell targeting peptide denoted by sequence number 1 as an effective component.
Abstract translation: 本发明涉及可以选择性识别和结合恶性未分化脑肿瘤干细胞的肿瘤干细胞靶向肽GICT，以及使用该肽的脑肿瘤诊断方法。 本发明提供了含有以序列号1表示的肿瘤干细胞靶向肽作为有效成分的恶性肿瘤的预防和治疗药物组合物。
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6.发明公开엔도스타틴 및 카복실에스터라제가 동시 과발현된 간엽줄기세포 및 이를 이용하여 신경교종을 예방, 치료 또는 재발 억제하는 방법 无效间歇性干细胞同时超表达内皮素和羧酰基转移酶，含有其的药物组合物和使用该方法预防，治疗和重新抑制GLIOMA的方法
公开(公告)号：KR1020120114468A
公开(公告)日：2012-10-17
申请号：KR1020110031979
申请日：2011-04-07
Applicant: 서울대학교산학협력단
IPC: C12N5/0775 , A61K35/28
CPC classification number: C12N5/0668 , A61K35/28
Abstract: PURPOSE: A mesenchymal stem cell in which endostatin and carboxyl esterase are concurrently over expressed and preventing, treating or recurrence suppression method of glioma by using the same are provided to drastically prevent carcinogenesis and recurrence. CONSTITUTION: In a mesenchymal stem cell, endostatin and carboxyl esterase are concurrently over expressed. A preventing, treating or recurrence suppression method of glioma includes a step of injecting the mesenchymal stem cell to all mammals except for human. A manufacturing method of human amniotic fluid-derived mesenchymal stem cell(AF-MSC) comprises the following steps: establishing positive number of primary cell cultivation in a minimum essential medium in which fetal bovine serum(ES-FBS) having 15% of embryonic stem cell, 2mM L-glutamine and 1% of penicillin streptomycin are contained, and 18% Chang culture medium B and 2% Chang culture medium C are supplemented; collecting cells by trypsinization for selective cultivation of AF-MSC; plating in DMEM low dextrose broth supplemented with 10% of FBS, 1% of penicillin streptomycin, 2mM L-glutamine and 4ng/mL basic fibroblast growth factor (bFGF: R&D); and obtaining morphologic interspecies population of the AF-MSC after second round of the subculture.
Abstract translation: 目的：提供内皮抑素和羧基酯酶同时过表达的间充质干细胞，通过使用胶质瘤预防，治疗或复发抑制方法，大幅度预防癌变和复发。 构成：在间充质干细胞中，内皮抑素和羧基酯酶同时过度表达。 胶质瘤的预防，治疗或复发抑制方法包括将间充质干细胞注射到除人之外的所有哺乳动物的步骤。 人类羊水间充质干细胞（AF-MSC）的制备方法包括以下步骤：在具有15％的胚胎干细胞的胎牛血清（ES-FBS）的最小必需培养基中建立阳性数量的原代细胞培养 细胞，2mM L-谷氨酰胺和1％青霉素链霉素，并补充18％Chang培养基B和2％Chang培养基C; 通过胰蛋白酶消化来收集细胞以选择性培养AF-MSC; 在补充有10％FBS，1％青霉素链霉素，2mM L-谷氨酰胺和4ng / mL碱性成纤维细胞生长因子（bFGF：R＆D）的DMEM低葡萄糖肉汤中电镀; 并在第二轮传代培养后获得AF-MSC的形态种间群体。
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公开(公告)号：KR101155306B1
公开(公告)日：2012-06-12
申请号：KR1020090095015
申请日：2009-10-07
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 유기용매 전처리에 의한 바이오매스 특히 리그닌 물성 변화를 유도시켜 효소가수분해 소화율을 개선하기 위한 것이다. 본 발명은 목질계 바이오매스를 대상으로 유기용매 전처리 단계 및 효소가수분해 단계를 포함하여 구성되는, 유기용매 전처리에 의한 바이오매스에 대한 효소가수분해 개선방법에 관한 것이며, 본 발명에 의하면, 바이오매스 특히 목질계 바이오매스의 리그닌의 구조적, 형태학적 변화를 통하여 유효기공의 증가가 달성되어 효소가수분해를 개선시킬 수 있고, 이에 따라 가수분해 생성물의 수율을 높일 수 있다.
유기용매 전처리, 효소가수분해, 리그닌 방울, 유효기공
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