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公开(公告)号：WO2014027826A1
公开(公告)日：2014-02-20
申请号：PCT/KR2013/007293
申请日：2013-08-13
Applicant: 서울대학교산학협력단
Inventor： 강헌중 , 왕웨이홍 , 김희영 , 기리아왓두트 가젠드라
IPC: C07D307/58 , A61K31/341 , A61P31/04 , A61P35/00
CPC classification number: C07D307/58
Abstract: 본 발명은 부테놀라이드계 화합물, 그의 입체이성질체, 그의 거울상이성질체, 생체 내에서 가수분해 가능한 그의 전구체 또는 약제학적으로 허용 가능한 그의 염 및 그들이 갖는 항균활성, 면역질환치료 및 예방 활성, 암의 예방 또는 치료 효능 및 의료용 삽입기기의 오손 방지 활성에 관한 것이다.
Abstract translation: 本发明涉及：丁烯酸酯类化合物; 其立体异构体; 其对映体; 其体内可水解的前体或其药学上可接受的盐; 和抗菌活性，免疫疾病治疗; 和预防功效，癌症预防或治疗功效以及关于其医疗插入器具的结垢的预防活动。
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公开(公告)号：KR102112753B1
公开(公告)日：2020-06-02
申请号：KR1020130111368
申请日：2013-09-16
Applicant: 서울대학교산학협력단 , 순천대학교 산학협력단
IPC: C07C49/786 , A23L33/10
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公开(公告)号：KR102028532B1
公开(公告)日：2019-11-04
申请号：KR1020120142143
申请日：2012-12-07
Applicant: 서울대학교산학협력단
IPC: C07F9/40 , A61K31/661 , A23L29/00
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公开(公告)号：KR101599426B1
公开(公告)日：2016-03-07
申请号：KR1020130096070
申请日：2013-08-13
Applicant: 서울대학교산학협력단
Inventor： 강헌중 , 왕웨이홍 , 김희영 , 기리아왓두트가젠드라
IPC: C07D307/58 , A61K31/341 , A61P31/04 , A61P37/00
CPC classification number: C07D307/58
Abstract: 본발명은부테놀라이드계화합물, 그의입체이성질체, 그의거울상이성질체, 생체내에서가수분해가능한그의전구체또는약제학적으로허용가능한그의염 및그들이갖는항균활성, 면역질환치료및 예방활성, 암의예방또는치료효능및 의료용삽입기기의오손방지활성에관한것이다.
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Patent Agency Ranking
公开(公告)号：KR1020140082451A
公开(公告)日：2014-07-02
申请号：KR1020120152442
申请日：2012-12-24
Applicant: 서울대학교산학협력단
IPC: A61K31/426 , A61K31/435 , A61P17/02 , A61P17/00
CPC classification number: A61K31/426 , A61K31/192 , A61K31/41 , A61K31/42 , A61K31/427 , A61K31/4439 , Y10S424/13 , Y10S514/925
Abstract: The present invention relates to a novel use of a PPARδ agonist and, particularly, to antibacterial activities, diabetic foot ulcer treatment and prevention ettects, and gash and burn treatment effects of a PPARδ agonist. According to the present invention, the PPARδ agonist has excellent antibacterial activities against methicillin- and vancomycin-resistant bacteria and can be used as an agent for preventing or treating multidrug resistance bacterial infection. The PPARδ agonist has excellent wound treating efficiency through the cell movement and proliferation of epidermal keratinocytes and has excellent ulcer treating efficiency in a diabetic ulcer animal model, so as to effectively treat gash, burn, and foot ulcer caused by diabetic complications.
Abstract translation: 本发明涉及PPARδ激动剂的新用途，特别涉及抗菌活性，糖尿病足溃疡治疗和预防疗法，以及PPARδ激动剂的间隙和烧伤治疗效果。 根据本发明，PPARδ激动剂对抗甲氧西林和万古霉素抗性细菌具有优异的抗菌活性，可用作预防或治疗多药耐药细菌感染的药剂。 PPARδ激动剂通过细胞运动和表皮角化细胞增殖具有优异的伤口治疗效果，并且在糖尿病溃疡动物模型中具有优异的溃疡治疗效果，从而有效治疗由糖尿病并发症引起的沟槽，烧伤和足部溃疡。
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公开(公告)号：KR1020140074015A
公开(公告)日：2014-06-17
申请号：KR1020120142143
申请日：2012-12-07
Applicant: 서울대학교산학협력단
CPC classification number: C07F9/40 , A23L29/05 , A61K31/661
Abstract: The present invention relates to a novel polyacetylene derivative represented by formula I which has activity to a peroxisome proliferator activated receptor (PPAR), hydrates thereof, solvates thereof, a stereoisomer thereof, pharmaceutically allowed salts thereof and use as medicines, a cosmetic composition, functional food, functional beverages and animal feed comprising the same.
Abstract translation: 本发明涉及一种新型的具有对过氧化物酶体增殖物激活受体（PPAR）活性的聚乙炔衍生物，其水合物，其溶剂合物，其立体异构体，其药学上允许的盐，用作药物，化妆品组合物，功能性 食品，功能饮料和包含其的动物饲料。
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公开(公告)号：KR1020140024221A
公开(公告)日：2014-02-28
申请号：KR1020130096070
申请日：2013-08-13
Applicant: 서울대학교산학협력단
Inventor： 강헌중 , 왕웨이홍 , 김희영 , 기리아왓두트가젠드라
IPC: C07D307/58 , A61K31/341 , A61P31/04 , A61P37/00
CPC classification number: C07D307/58
Abstract: The present invention relates to a butenolides compound, the stereoisomers and enantiomers thereof, precursors thereof which is hydrolyzable in the body, or a pharmaceutically acceptable salt, the antimicrobial activity, preventive activity against immune diseases, effects in preventing or treating cancer, and preventive activity against fouling of a medical introducer.
Abstract translation: 本发明涉及丁内酯化合物，其立体异构体和对映异构体，其在体内可水解的前体或其药学上可接受的盐，抗微生物活性，针对免疫疾病的预防活性，预防或治疗癌症的预防作用和预防活性 防止医疗导师的结垢。
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公开(公告)号：KR1020150032385A
公开(公告)日：2015-03-26
申请号：KR1020130111368
申请日：2013-09-16
Applicant: 서울대학교산학협력단 , 순천대학교 산학협력단
IPC: C07C49/786 , A61K31/12 , A61P3/10
Abstract: 본 발명은 벤조페논계 화합물과 그 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 당뇨 및 골다공증 예방 또는 치료용 약학적 조성물에 관한 것이다.
[화학식 I]Abstract translation: 本发明涉及用于预防或治疗糖尿病或骨质疏松症的药物组合物，其包括二苯甲酮类化合物及其衍生物或其药学上可接受的盐。 在本发明中，提供了由化学式I表示的新型二苯甲酮系衍生物的分离纯化方法。
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公开(公告)号：KR102038866B1
公开(公告)日：2019-10-31
申请号：KR1020120152442
申请日：2012-12-24
Applicant: 서울대학교산학협력단
IPC: A61K31/426 , A61K31/427 , A61K31/41 , A61K31/192 , A61K31/4439
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