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公开(公告)号：KR1020160104160A
公开(公告)日：2016-09-05
申请号：KR1020150026568
申请日：2015-02-25
Applicant: 서울대학교산학협력단 , 에이비온 주식회사
IPC: C07K16/18 , A61K39/395 , A61K33/24
CPC classification number: C07K16/18 , A61K33/24 , A61K39/39533 , C07K2317/565
Abstract: 본발명은암 예방또는치료에이용될수 있는클라우딘(Caludin) 3 및 4에대한항체에관한것이다. 본발명의항체는암 세포(특히, 난소암세포)에서과발현되는클라우딘 3 및 4에특이적으로결합하는항체로서, 기존의클라우딘 3 또는 4 타겟항체들의 CDR 서열과비교하여상동성이매우낮아, 그서열의독특함이있다. 본발명의항체는암세포를살상시켜암(특히, 난소암)의예방또는치료에매우유효하다.
Abstract translation: 本发明涉及可用于预防或治疗癌症的克劳丁3和4特异性抗体。 本发明的抗体是特异性结合克劳丁3和4的抗体，其在癌细胞（特别是卵巢癌细胞）中过表达，并且与常规克鲁丁蛋白3或4靶向抗体的CDR序列相比具有非常低的均匀性 ，从而具有序列的特性。 本发明的抗体杀死癌细胞，并且对于预防或治疗癌症（特别是卵巢癌）基本上是有效的。
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公开(公告)号：KR1020110028164A
公开(公告)日：2011-03-17
申请号：KR1020090086131
申请日：2009-09-11
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A composition containing microsphere containing stimuli-responsive biopolymers and albumin and a stem cell-suppressive material is provided to be used in a drug delivery carrier. CONSTITUTION: A composition for suppressing stem cell differentiation comprises: a microsphere containing stimuli-responsive biopolymers and albumin; and a stem cell-suppressive material which is inserted into the microspheres. The stimuli-responsive biopolymer is elastine-like polypeptide(ELP). The microsphere is cross-linked with glutaraldehyde. The stem cell-suppressive material is LIF(leukemia inhibitory factor).
Abstract translation: 目的：提供一种含有含有刺激响应生物聚合物和白蛋白的微球和含有干细胞抑制物质的组合物，用于药物递送载体。 构成：用于抑制干细胞分化的组合物包括：含有刺激响应的生物聚合物和白蛋白的微球; 和插入到微球中的干细胞抑制材料。 刺激响应生物聚合物是弹性蛋白样多肽（ELP）。 微球与戊二醛交联。 干细胞抑制物质是LIF（白血病抑制因子）。
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公开(公告)号：KR1020170118633A
公开(公告)日：2017-10-25
申请号：KR1020170121368
申请日：2017-09-20
Applicant: 서울대학교산학협력단 , 에이비온 주식회사
IPC: C07K16/18 , A61K39/395 , A61K33/24
Abstract: 본발명은암 예방또는치료에이용될수 있는클라우딘(Caludin) 3 및 4에대한항체에관한것이다. 본발명의항체는암 세포(특히, 난소암세포)에서과발현되는클라우딘 3 및 4에특이적으로결합하는항체로서, 기존의클라우딘 3 또는 4 타겟항체들의 CDR 서열과비교하여상동성이매우낮아, 그서열의독특함이있다. 본발명의항체는암세포를살상시켜암(특히, 난소암)의예방또는치료에매우유효하다.
Abstract translation: 本发明涉及可用于癌症预防或治疗的针对密蛋白3和4的抗体。 本发明的癌细胞结合keulrawoodin 3和4 eteuk传输在过表达的抗体的抗体（特别是卵巢癌），相比于现有keulrawoodin 3或4的CDR序列，靶抗体是非常低的同源性，序列 有独特之处。 本发明的抗体通过杀死癌细胞来预防或治疗癌症（特别是卵巢癌）是非常有效的。
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公开(公告)号：KR101141765B1
公开(公告)日：2012-05-03
申请号：KR1020090086131
申请日：2009-09-11
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A composition containing microsphere containing stimuli-responsive biopolymers and albumin and a stem cell-suppressive material is provided to be used in a drug delivery carrier. CONSTITUTION: A composition for suppressing stem cell differentiation comprises: a microsphere containing stimuli-responsive biopolymers and albumin; and a stem cell-suppressive material which is inserted into the microspheres. The stimuli-responsive biopolymer is elastine-like polypeptide(ELP). The microsphere is cross-linked with glutaraldehyde. The stem cell-suppressive material is LIF(leukemia inhibitory factor).
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