公开(公告)号：KR1020120057707A

公开(公告)日：2012-06-07

申请号：KR1020100080213

申请日：2010-08-19

Applicant: 서울대학교산학협력단

Inventor： 한재용 ,  송권화 ,  서희원 ,  최진원 ,  안은서

IPC: G01N33/574 ,  C12Q1/68 ,  C12N15/12 ,  G01N33/15

CPC classification number: G01N33/57449 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/15

Abstract: PURPOSE: A biomarker for diagnosing ovarian cancer and a cancer diagnosis kit are provided to simply and cheaply diagnose human ovarian cancer. CONSTITUTION: A kit for diagnosing cancer contains a binder which specifically binds to a nucleotide sequence encoding CLDN10(claudin 10) or MMP3(matix metalloproteinase 3) or a binder which is specific to CLDN10 or MMP3. The binder includes a probe, primer, antibody or aptamer. A pharmaceutical composition for preventing or treating cancer contains a material which suppresses CLDN10 or MMP3 expression as an active ingredient.

Abstract translation: 目的：诊断卵巢癌和癌症诊断试剂盒的生物标志物被简单且廉价地诊断人卵巢癌。 构成：用于诊断癌症的试剂盒含有特异性结合编码CLDN10（克隆蛋白10）或MMP3（matix金属蛋白酶3）的核苷酸序列或对CLDN10或MMP3特异的粘合剂的粘合剂。 粘合剂包括探针，引物，抗体或适体。 用于预防或治疗癌症的药物组合物含有抑制CLDN10或MMP3表达作为活性成分的材料。