公开(公告)号：KR1020110093427A

公开(公告)日：2011-08-18

申请号：KR1020100013470

申请日：2010-02-12

Applicant: 서울대학교산학협력단

Inventor： 성승용 ,  조남혁 ,  최신규 ,  장숙희 ,  원해영 ,  나혜영 ,  문혜정 ,  조성은

IPC: C07K16/18 ,  C12N15/63 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/3092

Abstract: PURPOSE: A single domain antibody or nanoscale antibody or nanoMAb is provided to diagnose cancer tissue which expresses MUC1 and to be used as an anti-tumor target therapeutic agent. CONSTITUTION: A single domain antibody for MUC1 contains a heavy chain variable region having: CDR1 selected from the group consisting of amino acids of sequence numbers 24-30; CDR2 selected from the group consisting of amino acids of sequence numbers 31-37; or CDR3 selected from the group consisting of amino acid of sequence number 38-44. The single domain antibody additionally contains a functional molecule. The functional molecule is chemicals, peptides, polypeptides, nucleic acids, carbohydrate, lipid, or inorganic particles.

Abstract translation: 目的：提供单域抗体或纳米抗体或纳米抗体，以诊断表达MUC1的癌组织，并用作抗肿瘤靶标治疗剂。 构成：用于MUC1的单结构域抗体包含重链可变区，其具有：CDR1，其选自序列号24-30的氨基酸; CDR2选自序列号31-37的氨基酸; 或选自序列号38-44的氨基酸的CDR3。 单结构域抗体另外含有功能性分子。 功能分子是化学物质，肽，多肽，核酸，碳水化合物，脂质或无机颗粒。