Abstract:
본 발명은 하기 화학식 1로 표시되는 화합물을 유효성분으로 함유하는 염증질환 치료제에 관한 것으로, 이러한 화합물은 LPS로 활성화된 RAW 264.7세포에서 NO, IL-6 및 TNF-a와 같은 염증성 매개물의 생성을 억제함으로써 염증 질환의 치료제로서 유용하게 이용될 수 있다. [화학식 1]
Abstract:
PURPOSE: A therapeutic agent containing a compound as an active ingredient for treating inflammatory disease is provided to suppress generation of inflammatory media such as NO(nitrogen oxide), IL-6(interleukin-6) and TNF-α(tumor necrosis factor-alpha) in LPS-activated RAW 264.7 cell. CONSTITUTION: A therapeutic agent for treating inflammatory diseases contains a compound of the chemical formula 1 as an active ingredient. In chemical formula 1, R is COOH, COOCH3, CH2OH or CH2NHCOCF3, R1 and R2 is H, C6H5, or Br, and m is 1-5 integer and n is 1-4 integer. The compound of chemical formula 1 is (E)-11-oxooctadeca-9-enole, (E)-10- oxooctadeca-8-enole, (E)-9-oxooctadeca-10-enole or (E)-8-oxooctadeca-9-enole. The inflammatory diseases are rheumatoid arthritis, inflammatory bowel disease, osteoporosis, psoriasis, or toxic shock syndrome.
Abstract:
본 발명은 패실로미세스 바리오티( Paecilomyces variotii )의 유기용매 추출물을 유효성분으로 포함하는 어류 병원성 미생물의 감염 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 어류 병원성 미생물의 감염 예방 또는 치료용 조성물을 어류에 경구투여 또는 수조투여 할 경우, 현재 사용되고 있는 항생제를 투여하지 않고서도 충분히 어병에 대한 면역력을 확보할 수 있으므로, 어류의 세균에 의한 감염을 효과적으로 방지할 수 있고, 항생제를 대체할 수 있는 효과가 있다.
Abstract:
PURPOSE: A pharmaceutical composition for preventing and treating cancer containing enoic acid fatty acid as an active ingredient is provided to suppress cell growth and induce apoptosis so prevent and treat cancer. CONSTITUTION: A pharmaceutical composition for preventing and treating cancer contains enone compound of chemical formula 1 or 2 as an active ingredient. In chemical formulas 1 and 2, R is OH, alkoxy group of C1-C4, COOH, COOCH3, CH2OH or CH2NHCOCF3, and m and n is integer of 2 to 4, respectively. A health food for treating cancer contains a compound of chemical formula 1 or 2 as an active ingredient. The enoic acid fatty acid compound induces apoptosis and suppresses cell growth by DNA replication. The dose of the enoic acid fatty acid is 2~10 mg/kg once or several time a day.
Abstract:
PURPOSE: A use of a Paecilomyces variotii extract for preventing or treating pathogenic bacterial infection in fish is provided to ensure immunity to fish diseases, and to prevent bacterial infection in fish. CONSTITUTION: A composition for preventing or treating pathogenic bacterial infection in fish contains an organic solvent extract of Paecilomyces variotii as an active ingredient. The organic solvent is selected from the group consisting of n-hexane, chloroform, ethyl acetate, and butanol. The organic solvent is ethyl acetate. The composition contains a compound denoted by chemical formula 1 as an active ingredient. A method for preventing or treating pathogenic bacterial infection in fish comprises a step of directly treating a water bath in which fish grows with the composition, or adsorbing the composition to a feed for growing fish in a concentration of 1.0-500ppm.