염증질환 치료제
    1.
    发明授权
    염증질환 치료제 有权
    治疗炎性疾病

    公开(公告)号:KR101012313B1

    公开(公告)日:2011-02-09

    申请号:KR1020080054293

    申请日:2008-06-10

    Abstract: 본 발명은 하기 화학식 1로 표시되는 화합물을 유효성분으로 함유하는 염증질환 치료제에 관한 것으로, 이러한 화합물은 LPS로 활성화된 RAW 264.7세포에서 NO, IL-6 및 TNF-a와 같은 염증성 매개물의 생성을 억제함으로써 염증 질환의 치료제로서 유용하게 이용될 수 있다.
    [화학식 1]

    염증질환, NO, IL-6, TNF-α

    염증질환 치료제
    2.
    发明公开
    염증질환 치료제 有权
    治疗炎症性疾病

    公开(公告)号:KR1020090128229A

    公开(公告)日:2009-12-15

    申请号:KR1020080054293

    申请日:2008-06-10

    Abstract: PURPOSE: A therapeutic agent containing a compound as an active ingredient for treating inflammatory disease is provided to suppress generation of inflammatory media such as NO(nitrogen oxide), IL-6(interleukin-6) and TNF-α(tumor necrosis factor-alpha) in LPS-activated RAW 264.7 cell. CONSTITUTION: A therapeutic agent for treating inflammatory diseases contains a compound of the chemical formula 1 as an active ingredient. In chemical formula 1, R is COOH, COOCH3, CH2OH or CH2NHCOCF3, R1 and R2 is H, C6H5, or Br, and m is 1-5 integer and n is 1-4 integer. The compound of chemical formula 1 is (E)-11-oxooctadeca-9-enole, (E)-10- oxooctadeca-8-enole, (E)-9-oxooctadeca-10-enole or (E)-8-oxooctadeca-9-enole. The inflammatory diseases are rheumatoid arthritis, inflammatory bowel disease, osteoporosis, psoriasis, or toxic shock syndrome.

    Abstract translation: 目的:提供含有化合物作为治疗炎性疾病的活性成分的治疗剂,以抑制炎症介质如NO(氮氧化物),IL-6(白细胞介素-6)和TNF-α(肿瘤坏死因子-α )在LPS激活的RAW 264.7细胞中。 构成:用于治疗炎性疾病的治疗剂含有化学式1的化合物作为活性成分。 在化学式1中,R为COOH,COOCH3,CH2OH或CH2NHCOCF3,R1和R2为H,C6H5或Br,m为1-5整数,n为1-4整数。 化学式1的化合物是(E)-11-氧代十八碳-9-烯醇,(E)-10-氧代十八碳-8-烯醇,(E)-9-氧代十八碳-10-烯醇或(E)-8-氧代十八碳烯 -9- enole。 炎症性疾病是类风湿性关节炎,炎性肠病,骨质疏松症,牛皮癣或中毒性休克综合征。

    에논 지방산 화합물을 유효성분으로 함유하는 암질환 예방및 치료용 약학조성물
    4.
    发明公开
    에논 지방산 화합물을 유효성분으로 함유하는 암질환 예방및 치료용 약학조성물 无效
    用于预防和治疗包含酸性脂肪酸的癌症疾病的药物组合物

    公开(公告)号:KR1020090128223A

    公开(公告)日:2009-12-15

    申请号:KR1020080054286

    申请日:2008-06-10

    Abstract: PURPOSE: A pharmaceutical composition for preventing and treating cancer containing enoic acid fatty acid as an active ingredient is provided to suppress cell growth and induce apoptosis so prevent and treat cancer. CONSTITUTION: A pharmaceutical composition for preventing and treating cancer contains enone compound of chemical formula 1 or 2 as an active ingredient. In chemical formulas 1 and 2, R is OH, alkoxy group of C1-C4, COOH, COOCH3, CH2OH or CH2NHCOCF3, and m and n is integer of 2 to 4, respectively. A health food for treating cancer contains a compound of chemical formula 1 or 2 as an active ingredient. The enoic acid fatty acid compound induces apoptosis and suppresses cell growth by DNA replication. The dose of the enoic acid fatty acid is 2~10 mg/kg once or several time a day.

    Abstract translation: 目的:提供一种用于预防和治疗含有烯酸脂肪酸的癌症作为活性成分的药物组合物,以抑制细胞生长并诱导凋亡,从而预防和治疗癌症。 构成:用于预防和治疗癌症的药物组合物含有化学式1或2的烯酮化合物作为活性成分。 在化学式1和2中,R是OH,C 1 -C 4的烷氧基,COOH,COOCH 3,CH 2 OH或CH 2 NHCOCF 3,m和n分别是2至4的整数。 用于治疗癌症的保健食品含有化学式1或2的化合物作为活性成分。 烯酸脂肪酸化合物诱导凋亡并通过DNA复制抑制细胞生长。 烯酸脂肪酸的剂量为2〜10mg / kg,一次或几次。

    패실로미세스 바리오티 추출물의 어류 병원성 미생물 감염 예방 또는 치료 용도
    5.
    发明公开
    패실로미세스 바리오티 추출물의 어류 병원성 미생물 감염 예방 또는 치료 용도 有权
    用于预防和治疗鱼致病性细菌感染的PAISILOMYCES VARIOTII的使用

    公开(公告)号:KR1020130051523A

    公开(公告)日:2013-05-21

    申请号:KR1020110116487

    申请日:2011-11-09

    CPC classification number: Y02A50/469 Y02A50/471 A61K31/352 A61K35/74

    Abstract: PURPOSE: A use of a Paecilomyces variotii extract for preventing or treating pathogenic bacterial infection in fish is provided to ensure immunity to fish diseases, and to prevent bacterial infection in fish. CONSTITUTION: A composition for preventing or treating pathogenic bacterial infection in fish contains an organic solvent extract of Paecilomyces variotii as an active ingredient. The organic solvent is selected from the group consisting of n-hexane, chloroform, ethyl acetate, and butanol. The organic solvent is ethyl acetate. The composition contains a compound denoted by chemical formula 1 as an active ingredient. A method for preventing or treating pathogenic bacterial infection in fish comprises a step of directly treating a water bath in which fish grows with the composition, or adsorbing the composition to a feed for growing fish in a concentration of 1.0-500ppm.

    Abstract translation: 目的:提供拟青霉提取物用于预防或治疗鱼类病原菌感染的用途,以确保对鱼类疾病的免疫力,并防止鱼类细菌感染。 构成:用于预防或治疗鱼类病原菌感染的组合物含有拟青霉的有机溶剂提取物作为活性成分。 有机溶剂选自正己烷,氯仿,乙酸乙酯和丁醇。 有机溶剂为乙酸乙酯。 组合物含有化学式1表示的化合物作为有效成分。 用于预防或治疗鱼类病原菌感染的方法包括直接处理其中鱼类与组合物生长的水浴或将组合物吸附至浓度为1.0-500ppm的鱼饲料的步骤。

Patent Agency Ranking