公开(公告)号：KR1020120065115A

公开(公告)日：2012-06-20

申请号：KR1020100126456

申请日：2010-12-10

Applicant: 서울대학교산학협력단

Inventor： 박형근 ,  주상섭 ,  홍석창 ,  이지혜

IPC: C07C67/343 ,  C07C69/38 ,  B01J31/02

CPC classification number: C07C67/343 ,  B01J31/02 ,  C07C69/38

Abstract: PURPOSE: A manufacturing method of optically pure alpha-dialkyl malonate is provided to manufacture asymmetric malonate having desired substituent through successive dialkylation. CONSTITUTION: A manufacturing method of optically pure alpha-dialkyl malonate which is represented by chemical formula 2 comprises the following steps: mixing a compound which is represented by chemical formula 1 and solvent with alkyl halide R-X under existence of (S,S)-NAS which is represented by chemical formula 4; and cooling the mixture down to -100-10 deg/ Celsius; and adding base to the frozen mixture. In the chemical formula 1 and 2, A and A' can be identical different, and are selected from phenyl radical, cyclohexyl group, and cyclopentyl group. The phenyl radical, cyclohexyl group, and cyclopentyl group can be substituted with a substituent which is selected from alkyl group having 1-10 carbons, phenyl radical, benzyl radical, allyl group, alkoxy radical, halogen, alkylester having 1-10 carbons, phenylester, and benzylester group. B is selected from hydrogen, alkyl group having 1-10 carbons, phenyl radical, allyl group, benzyl radical, and halogen. R is selected from alkyl group having 1-10 carbons, phenyl radical, allyl group, and benzyl radical.

Abstract translation: 目的：提供光学纯的丙二酸二烷基酯的制备方法，以通过连续二烷基化制备具有所需取代基的不对称丙二酸酯。 构成：由化学式2表示的光学纯的α-二烷基丙二酸酯的制造方法包括以下步骤：将由（S，S）-NAS存在的化学式1表示的化合物与溶剂与烷基卤RX混合 其由化学式4表示; 并将混合物冷却至-100-10℃/摄氏度; 并向冷冻混合物中加入碱。 在化学式1和化学式2中，A和A'可以相同，选自苯基，环己基和环戊基。 苯基，环己基和环戊基可以被选自具有1-10个碳的烷基，苯基，苄基，烯丙基，烷氧基，卤素，具有1-10个碳的烷基酯，苯基酯 ，和苄基酯基。 B选自氢，具有1-10个碳的烷基，苯基，烯丙基，苄基和卤素。 R选自具有1-10个碳的烷基，苯基，烯丙基和苄基。