公开(公告)号：KR101000358B1

公开(公告)日：2010-12-13

申请号：KR1020100040290

申请日：2010-04-29

Applicant: 서울대학교산학협력단

Inventor： 오유경 ,  김지연 ,  한수은 ,  변영로

IPC: A61K31/66 ,  A61K9/20 ,  A61P35/00

CPC classification number: A61K31/683 ,  A61K9/51 ,  A61K51/1244

Abstract: PURPOSE: An integrin alpha-V-beta 3 binding lipid derivative which selectively recognizes cells expressing integrin is provided to enhance drug delivery efficiency to various cancer cells. CONSTITUTION: An integrin alpha-V-beta 3 binding lipid derivative has a structure of chemical formula 1 or 2. A composition for preparing integrin alpha-V-beta 3-recognizing lipid nanoparticle contains the integrin alpha-V-beta 3 binding lipid derivative. The composition additionally contains positive charge lipid, neutral lipid or negative charge lipid. The lipid nanoparticle is formulated in liposome, micelle, emulsion or solid lipid nanoparticle. A pharmaceutical composition contains the alpha-V-beta 3-recognizing lipid nanoparticle and drug.

Abstract translation: 目的：提供选择性识别表达整联蛋白的细胞的整合素α-V-β3结合性脂质衍生物，以增强各种癌细胞的药物递送效率。 组成：整合素α-V-β3结合脂质衍生物具有化学式1或2的结构。用于制备整合素α-V-β3识别脂质纳米颗粒的组合物含有整联蛋白α-V-β3结合性脂质衍生物 。 该组合物另外含有正电荷脂质，中性脂质或负电荷脂质。 脂质纳米颗粒配制在脂质体，胶束，乳液或固体脂质纳米颗粒中。 药物组合物含有α-V-β3识别脂质纳米颗粒和药物。