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公开(公告)号：KR1020130020085A
公开(公告)日：2013-02-27
申请号：KR1020110082481
申请日：2011-08-18
Applicant: 성균관대학교산학협력단 , 대한민국 (식품의약품안전처장)
IPC: G01N33/493 , G01N33/15 , G01N33/48
CPC classification number: G01N33/493 , G01N33/00 , G01N33/15 , G01N33/48
Abstract: PURPOSE: A method for discriminating nephrotoxicity of a drug and a method for screening a nephrotoxicity-inducing material are provided to accurately determine nephrotoxicity with high sensitivity and specificity. CONSTITUTION: A method for determining nephrotoxicity of a drug comprises: a step of measuring concentration 1 of acetate and dimethyl glycine contained in urine from a drug-injected individual; a step of comparing concentration 1 with concentration 2 of acetate and dimethyl glycine contained in urine from a control group; and a step of determining whether concentration 1 is significantly changed. A method for screening a nephrotoxicity-inducing material comprises: a step of injecting a test composition or a test compound into an individual as an experimental group; a step of measuring and comparing the concentration of acetate and dimethyl glycine contained in urine from a control group; and a step of selecting a test composition or test compound which significantly changes the concentration of acetate and dimethyl glycine compared with the control group.
Abstract translation: 目的：提供用于鉴别药物肾毒性的方法和筛选肾毒性诱导物质的方法，以高灵敏度和特异性精确测定肾毒性。 构成：测定药物的肾毒性的方法，其特征在于，测定来自药物注射个体的尿液中所含的乙酸盐和二甲基甘氨酸的浓度1的步骤。 从对照组中比较浓缩物1与尿液中所含的乙酸盐和二甲基甘氨酸的浓度2的步骤; 以及确定浓度1是否显着改变的步骤。 筛选肾毒性诱导材料的方法包括：将试验组合物或试验化合物作为实验组注入个体的步骤; 测量和比较对照组尿液中所含的乙酸盐和二甲基甘氨酸的浓度的步骤; 以及与对照组相比，选择显着改变乙酸盐和二甲基甘氨酸浓度的测试组合物或测试化合物的步骤。
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公开(公告)号：KR1020130020086A
公开(公告)日：2013-02-27
申请号：KR1020110082482
申请日：2011-08-18
Applicant: 성균관대학교산학협력단 , 대한민국 (식품의약품안전처장)
IPC: G01N33/493 , G01N33/15 , G01N33/48
CPC classification number: G01N33/493 , G01N33/00 , G01N33/15 , G01N33/48
Abstract: PURPOSE: A method for determining nephrotoxicity using concentration change of acetate and trimethylamine-N-oxide(TMAO) contained in urine is provided to ensure high sensitivity and specificity. CONSTITUTION: A method for determining nephrotoxicity of a drug comprises: a step of measuring the concentration 1 of acetate and trimethylamine-N-oxide(TMAO) contained in urine which is injected with a drug; a step of comparing the concentration 2 of acetate and TMAO contained in urine from a control group; and a step of determining whether the concentration 1 is significantly changed.
Abstract translation: 目的：提供使用尿中含有的乙酸盐和三甲胺-N-氧化物（TMAO）的浓度变化来确定肾毒性的方法，以确保高灵敏度和特异性。 构成：测定药物的肾毒性的方法，包括：测定注射有药物的尿中含有的乙酸盐和三甲胺-N-氧化物（TMAO）的浓度1的步骤; 从对照组中比较尿中含有的乙酸盐浓度2和TMAO的步骤; 以及确定浓度1是否显着变化的步骤。
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公开(公告)号：KR1020130020084A
公开(公告)日：2013-02-27
申请号：KR1020110082480
申请日：2011-08-18
Applicant: 성균관대학교산학협력단 , 대한민국 (식품의약품안전처장)
IPC: G01N33/493 , G01N33/15 , G01N33/48
CPC classification number: G01N33/493 , G01N33/00 , G01N33/15 , G01N33/48
Abstract: PURPOSE: A method for determining nephrotoxicity of a drug using concentration change of acetate and citrate contained in urine is provided to ensure high sensitivity and specificity and to develop a safety novel drug. CONSTITUTION: A method for determining nephrotoxicity of a drug comprises: a step of measuring the concentration 1 of acetate and citrate contained in urine from a drug-injected individual; a step of comparing the concentration 1 with the concentration 2 of acetate and citrate contained in urine from a control group; and a step of determining whether the concentration 1 is significantly changed. The individual is a mammal exclusive of humans.
Abstract translation: 目的：提供使用尿中含有的醋酸盐和柠檬酸盐浓度变化来确定药物的肾毒性的方法，以确保高灵敏度和特异性，并开发出安全新型药物。 构成：测定药物的肾毒性的方法，包括：测定来自药物注射个体的尿液中所含的乙酸盐和柠檬酸盐的浓度1的步骤; 比较浓度1与来自对照组的尿液中所含的乙酸盐和柠檬酸的浓度2的步骤; 以及确定浓度1是否显着变化的步骤。 个人是不属于人类的哺乳动物。
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