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公开(公告)号：KR1020130020086A
公开(公告)日：2013-02-27
申请号：KR1020110082482
申请日：2011-08-18
Applicant: 성균관대학교산학협력단 , 대한민국 (식품의약품안전처장)
IPC: G01N33/493 , G01N33/15 , G01N33/48
CPC classification number: G01N33/493 , G01N33/00 , G01N33/15 , G01N33/48
Abstract: PURPOSE: A method for determining nephrotoxicity using concentration change of acetate and trimethylamine-N-oxide(TMAO) contained in urine is provided to ensure high sensitivity and specificity. CONSTITUTION: A method for determining nephrotoxicity of a drug comprises: a step of measuring the concentration 1 of acetate and trimethylamine-N-oxide(TMAO) contained in urine which is injected with a drug; a step of comparing the concentration 2 of acetate and TMAO contained in urine from a control group; and a step of determining whether the concentration 1 is significantly changed.
Abstract translation: 目的：提供使用尿中含有的乙酸盐和三甲胺-N-氧化物（TMAO）的浓度变化来确定肾毒性的方法，以确保高灵敏度和特异性。 构成：测定药物的肾毒性的方法，包括：测定注射有药物的尿中含有的乙酸盐和三甲胺-N-氧化物（TMAO）的浓度1的步骤; 从对照组中比较尿中含有的乙酸盐浓度2和TMAO的步骤; 以及确定浓度1是否显着变化的步骤。
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公开(公告)号：KR1020130020084A
公开(公告)日：2013-02-27
申请号：KR1020110082480
申请日：2011-08-18
Applicant: 성균관대학교산학협력단 , 대한민국 (식품의약품안전처장)
IPC: G01N33/493 , G01N33/15 , G01N33/48
CPC classification number: G01N33/493 , G01N33/00 , G01N33/15 , G01N33/48
Abstract: PURPOSE: A method for determining nephrotoxicity of a drug using concentration change of acetate and citrate contained in urine is provided to ensure high sensitivity and specificity and to develop a safety novel drug. CONSTITUTION: A method for determining nephrotoxicity of a drug comprises: a step of measuring the concentration 1 of acetate and citrate contained in urine from a drug-injected individual; a step of comparing the concentration 1 with the concentration 2 of acetate and citrate contained in urine from a control group; and a step of determining whether the concentration 1 is significantly changed. The individual is a mammal exclusive of humans.
Abstract translation: 目的：提供使用尿中含有的醋酸盐和柠檬酸盐浓度变化来确定药物的肾毒性的方法，以确保高灵敏度和特异性，并开发出安全新型药物。 构成：测定药物的肾毒性的方法，包括：测定来自药物注射个体的尿液中所含的乙酸盐和柠檬酸盐的浓度1的步骤; 比较浓度1与来自对照组的尿液中所含的乙酸盐和柠檬酸的浓度2的步骤; 以及确定浓度1是否显着变化的步骤。 个人是不属于人类的哺乳动物。
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公开(公告)号：KR1020130020085A
公开(公告)日：2013-02-27
申请号：KR1020110082481
申请日：2011-08-18
Applicant: 성균관대학교산학협력단 , 대한민국 (식품의약품안전처장)
IPC: G01N33/493 , G01N33/15 , G01N33/48
CPC classification number: G01N33/493 , G01N33/00 , G01N33/15 , G01N33/48
Abstract: PURPOSE: A method for discriminating nephrotoxicity of a drug and a method for screening a nephrotoxicity-inducing material are provided to accurately determine nephrotoxicity with high sensitivity and specificity. CONSTITUTION: A method for determining nephrotoxicity of a drug comprises: a step of measuring concentration 1 of acetate and dimethyl glycine contained in urine from a drug-injected individual; a step of comparing concentration 1 with concentration 2 of acetate and dimethyl glycine contained in urine from a control group; and a step of determining whether concentration 1 is significantly changed. A method for screening a nephrotoxicity-inducing material comprises: a step of injecting a test composition or a test compound into an individual as an experimental group; a step of measuring and comparing the concentration of acetate and dimethyl glycine contained in urine from a control group; and a step of selecting a test composition or test compound which significantly changes the concentration of acetate and dimethyl glycine compared with the control group.
Abstract translation: 目的：提供用于鉴别药物肾毒性的方法和筛选肾毒性诱导物质的方法，以高灵敏度和特异性精确测定肾毒性。 构成：测定药物的肾毒性的方法，其特征在于，测定来自药物注射个体的尿液中所含的乙酸盐和二甲基甘氨酸的浓度1的步骤。 从对照组中比较浓缩物1与尿液中所含的乙酸盐和二甲基甘氨酸的浓度2的步骤; 以及确定浓度1是否显着改变的步骤。 筛选肾毒性诱导材料的方法包括：将试验组合物或试验化合物作为实验组注入个体的步骤; 测量和比较对照组尿液中所含的乙酸盐和二甲基甘氨酸的浓度的步骤; 以及与对照组相比，选择显着改变乙酸盐和二甲基甘氨酸浓度的测试组合物或测试化合物的步骤。
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公开(公告)号：KR1020150057246A
公开(公告)日：2015-05-28
申请号：KR1020130140333
申请日：2013-11-19
Applicant: 대한민국 (식품의약품안전처장)
IPC: G01N27/416 , G01N27/30 , G01N33/02 , G01N27/06
CPC classification number: G01N27/416 , G01N27/06 , G01N27/30 , G01N33/02
Abstract: 본발명의일 실시예는나트륨간편측정염도계에관한것으로, 해결하고자하는기술적과제는시료의전기전도도값, 온도값, 염분의농도값및 나트륨의농도값, 점등위치를신속하고정확하게표시할수 있게하는데있다. 이를위해본 발명의일 실시예는몸체의내부에내장되는, 인쇄회로기판과상기인쇄회로기판에연결되는배터리와, 상기몸체의일단부에일단이상기인쇄회로기판에연결되도록설치되되, 상기일단의반대인타단은흑연도금층이형성되어시료에담겨지거나접촉되도록구비된적어도하나의전극및 온도센서를포함하는나트륨간편측정염도계이고, 상기인쇄회로기판은전원을공급하는전원공급부; 동작모드를선택하는모드선택부; 상기전극에의하여측정되는시료의전기전도도값을검출하는전도도측정부와상기온도센서에의하여측정되는시료의온도값을검출하는온도측정부를구비하는시료정보검출부; 상기시료의온도값에따른전기전도도값대비나트륨의농도값또는염분의농도값을미리저장하는메모리부; 상기측정된시료의전기전도도값과온도값을상기메모리부에저장된온도값에따른전기전도도값대비나트륨의농도값또는염분의농도값과비교하여, 상기측정된시료의전기전도도값과온도값에해당되는나트륨의농도값과염분의농도값을산출하는제어부; 및 LCD 모듈과, 적어도하나의 LED를구비하는 LED 모듈을포함하고, 상기모드선택부의선택에따라상기제어부에서산출된시료의전기전도도값과온도값에해당되는나트륨의농도값과염분의농도값을상기 LCD 모듈또는 LED 모듈에표시하는디스플레이부;를포함하는나트륨간편측정염도계를개시한다.
Abstract translation: 本发明涉及用于简单测量钠的盐度计。 要达到的技术目标是快速且准确地显示样品的电导率值，温度值，盐浓度值和钠浓度值以及照明位置。 为此，根据本发明的实施例，用于简单测量钠的盐度计包括：电池; 至少一个电极; 和温度传感器。 用于简单测量钠的盐度计包括印刷电路板，包括：提供电源的电源供应单元; 选择运动模式的模式选择单元; 样本信息检测单元，其具有检测所述样本的电导率值并具有温度测量单元的电导率测量单元; 记忆单元 计算钠浓度值和盐浓度值的控制单元; 以及显示单元，包括LCD模块，并且包括LED模块，并且在LCD模块或LED模块上显示钠浓度值和盐浓度值。
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Patent Agency Ranking
公开(公告)号：KR1020170040878A
公开(公告)日：2017-04-14
申请号：KR1020150140081
申请日：2015-10-06
Applicant: 대한민국 (식품의약품안전처장)
Abstract: 본발명은식품에첨가되는식품첨가물중 유화제및 습윤제용도로사용되는프로필렌글리콜및 불허용인공감미료로알려진에틸렌글리콜을정성정량분석하는동시분석방법에관한기술이다.
Abstract translation: 本发明是与同时分析方法对结晶乙二醇定量分析，被称为丙二醇和bulheoyong被用作食物乳化剂和添加剂的润湿剂的目的被添加到食品中人造甜味剂的技术。
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公开(公告)号：KR1020160109406A
公开(公告)日：2016-09-21
申请号：KR1020150033743
申请日：2015-03-11
Applicant: 창원대학교 산학협력단 , 대한민국 (식품의약품안전처장)
Abstract: 본발명은청소년식생활평가도구와이를이용한식사종류별반정량적식품섭취빈도조사방법에관한것으로, 보다상세하게는청소년식생활평가도구와네트워크, 사용자단말기, 메인서버및 데이터베이스를포함하는식품섭취빈도조사시스템을이용한청소년식품섭취빈도조사방법에있어서, 상기청소년식생활평가도구는아침식사에대한질문, 점심식사에대한질문, 저녁식사에대한질문, 간식에대한질문, 조사결과보기를포함하는안내페이지와조사페이지로구성되고, 상기메인서버는사용자단말기로부터수신되는요청데이터를분석하고, 요청데이터에해당하는청소년식품섭취빈도조사데이터또는청소년식생활평가데이터를데이터베이스를검색하여그 결과를사용자단말기로전송하는단계와; 사용자단말기는메인서버로부터전송되는청소년식품섭취빈도조사데이터또는청소년식생활평가데이터를화면으로출력하는단계를포함한다. 이에따라, 본발명은청소년식품안전영양교육컨텐츠개발과식생활평가도구표준화를통하여청소년의식품안전및 영양안전의인식과실천을향상시켜미래사회의주역인청소년의건강을확보하여건강한국가발전에기여할수 있는매우유용한발명인것이다.
Abstract translation: 本发明涉及一种用于青少年食物寿命的评估工具和用于使用其评估每种膳食种类的半定量营养摄入频率的方法，更具体地，涉及一种使用以下方法测量青少年的营养摄入频率的方法： 用于测量营养摄入频率的系统，其中用于测量营养摄入频率的系统包括用于青少年食物寿命的评估工具，网络，用户终端，主服务器和数据库。 青少年食物生活的评估工具包括指导页面和测量页面，包括关于早餐的询问，午餐的询问，晚餐的查询，关于茶点的查询和检查调查结果。 用于测量营养摄取频率的方法包括：分析从用户终端接收到的请求数据并通过搜索与该请求对应的青少年营养摄入频率或青少年食物寿命评估数据的调查数据向用户终端发送搜索结果的步骤 数据库中的数据库，由主服务器; 以及由用户终端在屏幕上输出关于从主服务器发送的青少年营养摄入频率或青少年食物生活评估数据的调查数据的步骤。 因此，青少年食物生活的评估工具和测量青少年营养摄入量的方法可以通过改善对未来社会的领导作用的青少年的健康，通过改善食物的认识和实践来促进健康的国家发展 通过食品生活评估工具的标准化和青少年食品安全和营养安全教育内容的发展，青少年的安全和营养安全。
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公开(公告)号：KR1020040110730A
公开(公告)日：2004-12-31
申请号：KR1020030040171
申请日：2003-06-20
Applicant: 대한민국 (식품의약품안전처장)
IPC: A01K67/027
CPC classification number: A01K67/0276 , A01K2227/105 , C12N15/63
Abstract: PURPOSE: A transgenic Alzheimer's mice expressing APPsw gene and a preparation method thereof are provided to show almost perfect Alzheimer symptoms and to be used in developing an Alzheimer treatment and an early diagnosis manner. CONSTITUTION: The preparation method of the transgenic Alzheimer's mice expressing APPsw(Amyloid precursor protein swedish) gene comprises the steps of: preparing a recombinant fusion gene by connecting an APPsw gene to a promoter of a NSE(Neur on-Specific Enolase) gene; microinjecting the recombinant fusion gene into a fertilized egg of a mouse; and breeding by nidating the fertilized egg into an abduct of a surrogate mother mouse.
Abstract translation: 目的：提供表达APPsw基因的转基因阿尔茨海默氏小鼠及其制备方法，以显示几乎完美的阿尔茨海默症状，并用于开发阿尔茨海默病和早期诊断。 构成：表达APPsw（淀粉样前体蛋白质瑞典）基因的转基因阿尔茨海默氏小鼠的制备方法包括以下步骤：通过将APPsw基因连接到NSE（Neur on-Specific Enolase）基因的启动子来制备重组融合基因; 将重组融合基因显微注射入小鼠的受精卵中; 并通过将受精卵覆盖到替代母亲小鼠的绑架中进行繁殖。
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公开(公告)号：KR101560732B1
公开(公告)日：2015-10-22
申请号：KR1020130140333
申请日：2013-11-19
Applicant: 대한민국 (식품의약품안전처장)
IPC: G01N27/416 , G01N27/30 , G01N33/02 , G01N27/06
Abstract: 본발명의일 실시예는나트륨간편측정염도계에관한것으로, 해결하고자하는기술적과제는시료의전기전도도값, 온도값, 염분의농도값및 나트륨의농도값, 점등위치를신속하고정확하게표시할수 있게하는데있다. 이를위해본 발명의일 실시예는몸체의내부에내장되는, 인쇄회로기판과상기인쇄회로기판에연결되는배터리와, 상기몸체의일단부에일단이상기인쇄회로기판에연결되도록설치되되, 상기일단의반대인타단은흑연도금층이형성되어시료에담겨지거나접촉되도록구비된적어도하나의전극및 온도센서를포함하는나트륨간편측정염도계이고, 상기인쇄회로기판은전원을공급하는전원공급부; 동작모드를선택하는모드선택부; 상기전극에의하여측정되는시료의전기전도도값을검출하는전도도측정부와상기온도센서에의하여측정되는시료의온도값을검출하는온도측정부를구비하는시료정보검출부; 상기시료의온도값에따른전기전도도값대비나트륨의농도값또는염분의농도값을미리저장하는메모리부; 상기측정된시료의전기전도도값과온도값을상기메모리부에저장된온도값에따른전기전도도값대비나트륨의농도값또는염분의농도값과비교하여, 상기측정된시료의전기전도도값과온도값에해당되는나트륨의농도값과염분의농도값을산출하는제어부; 및 LCD 모듈과, 적어도하나의 LED를구비하는 LED 모듈을포함하고, 상기모드선택부의선택에따라상기제어부에서산출된시료의전기전도도값과온도값에해당되는나트륨의농도값과염분의농도값을상기 LCD 모듈또는 LED 모듈에표시하는디스플레이부;를포함하는나트륨간편측정염도계를개시한다.
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公开(公告)号：KR1020040076735A
公开(公告)日：2004-09-03
申请号：KR1020030012079
申请日：2003-02-26
Applicant: 대한민국 (식품의약품안전처장)
IPC: A01K67/027
CPC classification number: A01K67/0276 , A01K2227/105 , C12N15/09
Abstract: PURPOSE: A transgenic dementia mouse expressing a mutant PS2 gene and a manufacturing process thereof are provided to be utilized usefully in treating a dementia disease or improving an early diagnosis process of the disease. CONSTITUTION: The manufacturing process of the transgenic dementia mouse expressing a mutant PS2 gene comprises the steps of: preparing a hybrid gene NSE/hPS2m by connecting to a promoter of a neuron-specific enolase gene to a mutant PS2 dementia gene derived from a human; micro-injecting the hybrid gene into a fertilized egg of a mouse; and implanting the fertilized egg into an oviduct of a surrogate mother mouse.
Abstract translation: 目的：提供一种表达突变型PS2基因的转基因痴呆小鼠及其制备方法，可用于治疗痴呆疾病或改善疾病的早期诊断过程。 构成：表达突变型PS2基因的转基因痴呆小鼠的制造方法包括以下步骤：通过将神经元特异性烯醇化酶基因的启动子连接到源自人的突变型PS2痴呆基因来制备杂合基因NSE / hPS2m; 将杂交基因微注射到小鼠的受精卵中; 并将受精卵植入代孕母鼠的输卵管中。
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