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Patent Agency Ranking
公开(公告)号：KR102120223B1
公开(公告)日：2020-06-08
申请号：KR1020180158570
申请日：2018-12-10
Applicant: 세종대학교산학협력단
IPC: A61K39/395 , A23L33/10 , A61K39/00
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公开(公告)号：KR101266649B1
公开(公告)日：2013-05-22
申请号：KR1020110045474
申请日：2011-05-16
Applicant: 세종대학교산학협력단
IPC: C07K16/18 , G01N33/577 , C12N5/16 , C12N15/13
Abstract: 본발명은미분화인간배아줄기세포에특이적으로결합하는단일클론항체및 이를생산하는하이브리도마에관한것으로서, 구체적으로는미분화인간배아줄기세포에는결합하나미분화생쥐배아줄기세포나분화된인간배아줄기세포에는결합하지않거나결합력이현저히약한단일클론항체 297-D4와상기단일클론항체를생산하는하이브리도마297-D4, 상기단일클론항체 297-D4를포함하는검정키트및 인간배아줄기세포제거용조성물에관한것이다.
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公开(公告)号：KR1020120127774A
公开(公告)日：2012-11-26
申请号：KR1020110045474
申请日：2011-05-16
Applicant: 세종대학교산학협력단
IPC: C07K16/18 , G01N33/577 , C12N5/16 , C12N15/13
Abstract: PURPOSE: A monoclonal antibody which specifically binds to undifferentiated human embryonic stem cells and a hybridoma producing the same are provided to study human embryonic stem cells. CONSTITUTION: A monoclonal antibody 297-D4 which is specific to undifferentiated human embryonic stem cells contain heavy chain variable domain(VH) with an amino acid sequence of sequence number 1 and a light chain variable domain(VL) with an amino acid sequence of sequence number 2. The monoclonal antibody is IgG1.k isotype and recognizes undifferentiated human embryonic stem cell BAP31-like proteins. A composition for removing the stem cells contains monoclonal antibody 297-D4. A kit for detecting the stem cells contains 297-D4. A method for isolating the stem cells comprises: a step of adding the monoclonal antibody 297-D4 to a cell group; and a step of isolating cells which combined with the monoclonal antibody 297-D4.
Abstract translation: 目的：提供特异性结合未分化的人胚胎干细胞的单克隆抗体和产生其的杂交瘤以研究人胚胎干细胞。 构成：对未分化的人胚胎干细胞特异性的单克隆抗体297-D4含有具有序列号1的氨基酸序列的重链可变区（VH）和具有序列氨基酸序列的轻链可变结构域（VL） 单克隆抗体是IgG1.k同种型并识别未分化的人胚胎干细胞BAP31样蛋白。 用于除去干细胞的组合物含有单克隆抗体297-D4。 用于检测干细胞的试剂盒含有297-D4。 分离干细胞的方法包括：将单克隆抗体297-D4加入细胞组的步骤; 以及分离与单克隆抗体297-D4组合的细胞的步骤。
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公开(公告)号：KR1020090123764A
公开(公告)日：2009-12-02
申请号：KR1020080134165
申请日：2008-12-26
Applicant: 세종대학교산학협력단
Abstract: PURPOSE: A monoclonal antibody which specifically binds to undifferentiated human stem cells is provided to research difference of initial embryo development between rat and human. CONSTITUTION: An undifferentiated human embryonic stem cell-specific monoclonal antibody 247-B9 contains variable region of heavy chain having an amino acid of the sequence number 6 and variable region of light chain having an amino acid of the sequence number 8. The monoclonal antibody 247-B9 recognizes about 37kDa protein of undifferentiated human embryonic stem cell and hnRNP A2/B1 analog protein. A composition for removing the undifferentiated human embryonic stem cell contains the monoclonal antibody 247-B9.
Abstract translation: 目的：提供特异性结合未分化人干细胞的单克隆抗体，以研究大鼠和人之间初始胚胎发育的差异。 构成：未分化的人胚胎干细胞特异性单克隆抗体247-B9含有具有序列号6的氨基酸的重链的可变区和具有序列号8的氨基酸的轻链的可变区。单克隆抗体247 -B9识别出未分化的人胚胎干细胞和hnRNP A2 / B1类似蛋白的37kDa蛋白。 用于去除未分化的人胚胎干细胞的组合物含有单克隆抗体247-B9。
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公开(公告)号：KR101084990B1
公开(公告)日：2011-11-18
申请号：KR1020080134165
申请日：2008-12-26
Applicant: 세종대학교산학협력단
Abstract: 본 발명은 미분화 인간 배아줄기세포에 특이적으로 결합하는 단일클론항체 및 이를 생산하는 하이브리도마에 관한 것으로서, 구체적으로는 미분화 인간 배아줄기세포에는 결합하고 분화된 인간 배아줄기세포에는 결합하지 않거나 결합력이 현저히 약한 단일클론항체 247-B9와 상기 단일클론항체를 생산하는 하이브리도마 247-B9, 상기 단일클론항체 247-B9을 포함하는 검정키트 및 인간 배아줄기세포 제거용 조성물에 관한 것이다.
미분화 인간 배아줄기세포, 단일클론항체, 하이브리도마, hnRNP A2/B1유사단백질
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