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    수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
    2.
    发明授权
    수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물 失效
    数量和质量

    公开(公告)号：KR100724586B1

    公开(公告)日：2007-06-04

    申请号：KR1020050120371

    申请日：2005-12-09

    Applicant: 세종대학교산학협력단 ,  재단법인서울대학교산학협력재단

    Inventor： 임동렬 ,  정진호 ,  박원철

    IPC: C07F13/00 ,  C07D471/00 ,  C07F1/08

    Abstract: A pentaaza macrocycle metal complex is provided to show excellent active oxygen scavenging capability with less toxicity and side effect, thereby being used as a pharmaceutical composition for preventing or treating diseases related to the active oxygen such as skin aging, cancer, dementia, and rheumatoid. The pentaaza macrocycle metal complex is represented by the formula(I), wherein each R1, R2, R3 and R4 is independently H or C1-4 alkyl substituted by a hetero cycle or an aromatic cycle, the hetero cycle and the aromatic cycle able to be substituted by at least one substituent selected from the group consisting of C1-4 alkoxy, halogen, nitro, cyano, hydroxy, carboxyl and amino, each R5 and R6 is independently C1-7 alkyl or the R5 and R6 form a ring by being bound by C3-5 alkylene, M is a divalent metal selected from the group consisting of Mn, Fe and Cu, and each X and Y is independently a halide anion selected from the group consisting of Cl, Br, I, ClO3, ClO2, ClO, BrO4, BrO3, BrO2, BrO, IO4, and IO3, an anion of an organocarboxylic acid selected from the group consisting of acetic acid, trifluoroacetic acid, citric acid, formic acid, maleic acid, oxalic acid, succinic acid, benzoic acid, tartaric acid, fumaric acid, mandelic acid, ascorbic acid, malic acid, methane sulfonic acid, benzene sulfonic acid and para-toluene sulfonic acid, an anion of a nitrate or a bicarbonate, and carboxylate or phenolate linked to one of the R1 to R6, provided that at least one of the R1, R2, R3 and R4 is not H. The pharmaceutical composition for preventing and treating cancer, stroke, Parkinson's disease, Alzheimer's disease, myocardial infarction, diabetic vascular disorder, hyperlipidemia, acute inflammation, rheumatoid, alcoholic hepatitis, glaucoma, macular degeneration and diabetic retinopathy comprises the pentaaza macrocycle metal complex as an effective ingredient.

    Abstract translation: 本发明提供五氮杂大环金属络合物，其显示优异的活性氧清除能力，毒性和副作用较小，因此可用作预防或治疗与皮肤老化，癌症，痴呆和类风湿等活性氧有关的疾病的药物组合物。 五氮杂大环金属配合物由式（I）表示，其中每个R 1，R 2，R 3和R 4独立地为H或被杂环或芳环取代的C 1-4烷基，杂环和芳环可以 被至少一个选自C 1-4烷氧基，卤素，硝基，氰基，羟基，羧基和氨基的取代基取代，每个R 5和R 6独立地为C 1-7烷基或者R 5和R 6通过 M是选自Mn，Fe和Cu的二价金属，并且每个X和Y独立地是选自Cl，Br，I，ClO 3，ClO 2， ClO，BrO 4，BrO 3，BrO 2，BrO，IO 4和IO 3，选自乙酸，三氟乙酸，柠檬酸，甲酸，马来酸，草酸，琥珀酸，苯甲酸的有机羧酸的阴离子 ，酒石酸，富马酸，扁桃酸，抗坏血酸，苹果酸，甲磺酸，b 苯磺酸和对甲苯磺酸，硝酸盐或碳酸氢盐的阴离子以及与R1-R6之一连接的羧酸盐或酚盐，条件是R1，R2，R3和R4中的至少一个不是H. 用于预防和治疗癌症，中风，帕金森病，阿尔茨海默氏病，心肌梗塞，糖尿病血管病症，高脂血症，急性炎症，类风湿，酒精性肝炎，青光眼，黄斑变性和糖尿病性视网膜病的药物组合物包含五氮杂大环金属络合物作为有效 成分。

    셀레노펜-접합 방향족 화합물, 및 이의 제조 방법
    8.
    发明公开
    셀레노펜-접합 방향족 화합물, 및 이의 제조 방법 有权
    SELENOPHENE-FUSED AROMATIC COMPOUNDS，及其制备方法

    公开(公告)号：KR1020130034638A

    公开(公告)日：2013-04-05

    申请号：KR1020120109215

    申请日：2012-09-28

    Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

    Inventor： 임동렬 ,  남도현 ,  두베이라스미 ,  이한근

    IPC: C07C391/00 ,  A61K31/095 ,  A61P35/00

    Abstract: PURPOSE: A manufacturing method of a selenophene-fused aromatic compound is provided to obtain various selenophene-fused aromatic compounds at a high yield by varying the kinds of aromatic stating materials. CONSTITUTION: A manufacturing method of a selenophene-fused aromatic compound represented by chemical formula 2 comprises: a step of preparing a diselenide compound represented by chemical formula R^1-CH2-Se-Se-CH2-R^1, a solvent, and a reducing agent; and a step of conducting a reaction by adding an aromatic starting material represented by chemical formula 1 and a base into the reaction mixture. The solvent is selected among dimethylsulfoxide, tetrahydrofuran, CH2Cl2, CH3CN, CH3NO2, CHCl3, ClCH2, CH2Cl, alcohol, an aromatic solvent, and a combination thereof.

    Abstract translation: 目的：提供硒代酚稠合芳香族化合物的制造方法，通过改变芳族化合物的种类，以高收率得到各种硒酚稠合芳香族化合物。 构成：由化学式2表示的硒吩酚稠合芳族化合物的制造方法包括：制备由化学式R 1〜2-Se-Se-CH 2 -R 1表示的二硒化合物的溶剂，溶剂和 还原剂; 以及通过将由化学式1表示的芳族起始原料和碱添加到反应混合物中进行反应的步骤。 溶剂选自二甲基亚砜，四氢呋喃，CH 2 Cl 2，CH 3 CN，CH 3 NO 2，CHCl 3，ClCH 2，CH 2 Cl，醇，芳族溶剂及其组合。

    히스티딘을 포함하는 펩타이드 유사체 및 항바이러스제 또는 항암제로서의 이의 용도
    10.
    发明公开
    히스티딘을 포함하는 펩타이드 유사체 및 항바이러스제 또는 항암제로서의 이의 용도 有权
    肽衍生物，包括抗病毒药物和抗肿瘤剂

    公开(公告)号：KR1020100106791A

    公开(公告)日：2010-10-04

    申请号：KR1020090024979

    申请日：2009-03-24

    Applicant: 주식회사 알로페론 ,  세종대학교산학협력단

    Inventor： 김수인 ,  이왕재 ,  임동렬

    IPC: C07K7/06 ,  A61K38/08 ,  A61P31/12 ,  A61P35/00

    Abstract: PURPOSE: An antiviral or anticancer drug containing peptide analogue with histidine is provided to control NF-kappaB activity and to prevent or treat NF-kappaB-associated diseases. CONSTITUTION: A peptide analogue with histidine is denoted by formula I(X1-His-X2-X3-His-Gly-X4). In formula I, X does not exist or is at least one amino acid or amino acid having alkyl or an aryl group; X2 is an amino acid having beta-amino acid, gamma-amino acid, D-form amino acid, or N-methyl amino acid; X3 does not exist or is an amino acid with gamma-amino acid, D-form amino acid or N-methyl amino acid; X3 does not exist or is an amino acid having L-form amino acid, D-form amino acid, or N-methyl amino acid; and X4 is an amino acid having L-form amino acid, D-form amino acid or N-methyl amino acid. The peptide analogue is Gly-His-β-Ala-Gln-His-Gly-Val. A composition for treating a NF-kappaB-associated disease contains NF-kappaB activity-regulating material having the peptide analogue and hydrate or salt thereof as an active ingredient.

    Abstract translation: 目的：提供含有组氨酸的肽类似物的抗病毒或抗癌药物以控制NF-κB活性并预防或治疗NF-κB相关疾病。 构成：具有组氨酸的肽类似物由式I（X1-His-X2-X3-His-Gly-X4）表示。 在式I中，X不存在或至少一个具有烷基或芳基的氨基酸或氨基酸; X2是具有β-氨基酸，γ-氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X3不存在或是具有γ-氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X3不存在或是具有L-型氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X4是具有L-型氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸。 肽类似物是Gly-His-β-Ala-Gln-His-Gly-Val。 用于治疗NF-κB相关疾病的组合物含有具有肽类似物和水合物或其盐作为活性成分的NF-κB活性调节材料。

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