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公开(公告)号：KR100724586B1
公开(公告)日：2007-06-04
申请号：KR1020050120371
申请日：2005-12-09
Applicant: 세종대학교산학협력단 , 재단법인서울대학교산학협력재단
IPC: C07F13/00 , C07D471/00 , C07F1/08
Abstract: A pentaaza macrocycle metal complex is provided to show excellent active oxygen scavenging capability with less toxicity and side effect, thereby being used as a pharmaceutical composition for preventing or treating diseases related to the active oxygen such as skin aging, cancer, dementia, and rheumatoid. The pentaaza macrocycle metal complex is represented by the formula(I), wherein each R1, R2, R3 and R4 is independently H or C1-4 alkyl substituted by a hetero cycle or an aromatic cycle, the hetero cycle and the aromatic cycle able to be substituted by at least one substituent selected from the group consisting of C1-4 alkoxy, halogen, nitro, cyano, hydroxy, carboxyl and amino, each R5 and R6 is independently C1-7 alkyl or the R5 and R6 form a ring by being bound by C3-5 alkylene, M is a divalent metal selected from the group consisting of Mn, Fe and Cu, and each X and Y is independently a halide anion selected from the group consisting of Cl, Br, I, ClO3, ClO2, ClO, BrO4, BrO3, BrO2, BrO, IO4, and IO3, an anion of an organocarboxylic acid selected from the group consisting of acetic acid, trifluoroacetic acid, citric acid, formic acid, maleic acid, oxalic acid, succinic acid, benzoic acid, tartaric acid, fumaric acid, mandelic acid, ascorbic acid, malic acid, methane sulfonic acid, benzene sulfonic acid and para-toluene sulfonic acid, an anion of a nitrate or a bicarbonate, and carboxylate or phenolate linked to one of the R1 to R6, provided that at least one of the R1, R2, R3 and R4 is not H. The pharmaceutical composition for preventing and treating cancer, stroke, Parkinson's disease, Alzheimer's disease, myocardial infarction, diabetic vascular disorder, hyperlipidemia, acute inflammation, rheumatoid, alcoholic hepatitis, glaucoma, macular degeneration and diabetic retinopathy comprises the pentaaza macrocycle metal complex as an effective ingredient.
Abstract translation: 本发明提供五氮杂大环金属络合物，其显示优异的活性氧清除能力，毒性和副作用较小，因此可用作预防或治疗与皮肤老化，癌症，痴呆和类风湿等活性氧有关的疾病的药物组合物。 五氮杂大环金属配合物由式（I）表示，其中每个R 1，R 2，R 3和R 4独立地为H或被杂环或芳环取代的C 1-4烷基，杂环和芳环可以 被至少一个选自C 1-4烷氧基，卤素，硝基，氰基，羟基，羧基和氨基的取代基取代，每个R 5和R 6独立地为C 1-7烷基或者R 5和R 6通过 M是选自Mn，Fe和Cu的二价金属，并且每个X和Y独立地是选自Cl，Br，I，ClO 3，ClO 2， ClO，BrO 4，BrO 3，BrO 2，BrO，IO 4和IO 3，选自乙酸，三氟乙酸，柠檬酸，甲酸，马来酸，草酸，琥珀酸，苯甲酸的有机羧酸的阴离子 ，酒石酸，富马酸，扁桃酸，抗坏血酸，苹果酸，甲磺酸，b 苯磺酸和对甲苯磺酸，硝酸盐或碳酸氢盐的阴离子以及与R1-R6之一连接的羧酸盐或酚盐，条件是R1，R2，R3和R4中的至少一个不是H. 用于预防和治疗癌症，中风，帕金森病，阿尔茨海默氏病，心肌梗塞，糖尿病血管病症，高脂血症，急性炎症，类风湿，酒精性肝炎，青光眼，黄斑变性和糖尿病性视网膜病的药物组合物包含五氮杂大环金属络合物作为有效 成分。
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公开(公告)号：KR101050273B1
公开(公告)日：2011-07-19
申请号：KR1020080116406
申请日：2008-11-21
Applicant: 세종대학교산학협력단
Abstract: 본 발명은 하기 의 살렌 전이금속 착화합물을 개시한다:
상기 식에서,
R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , R
12 , Ar
1 , Ar
2 , A , M, X, m 및 n은 발명의 상세한 설명을 참조한다.
살렌Abstract translation: 本发明涉及到＆lt;公开的沙仑 - 过渡金属配合物;式1＆GT：
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公开(公告)号：KR1020100057382A
公开(公告)日：2010-05-31
申请号：KR1020080116406
申请日：2008-11-21
Applicant: 세종대학교산학협력단
CPC classification number: C07F13/005
Abstract: PURPOSE: A salen transition metal complex is provided to improve antioxidant activity by introducing ethylene glycol group. CONSTITUTION: A salen transition metal complex compound is denoted by chemical formula 1, 2, 3, or 4. A method for preparing the salen transition metal complex compound comprises: a step of reacting benzaldehyde compound protected with benzyl group with boronic acid compound by Suzuki cross-coupling method to obtain a compound of chemical formula 34; a step of reacting the compound of chemical formula 34 with tosylated alkylene glycol monoalkylether to obtain a compound of chemical formula 35; a step of removing benzyl group from the compound of chemical formula 35 to obtain a compound of chemical formula 36; and a step of reacting the compounds of chemical formulas 35 and 37 with a transition metal compound under salt containing halogen atom.
Abstract translation: 目的：提供萨伦过渡金属络合物，通过引入乙二醇基团来提高抗氧化活性。 构成：化学式1,2,3或4表示盐析过渡金属络合物。一种制备沙伦过渡金属络合物的方法，其特征在于，包括：使用苄基保护的苯甲醛化合物与硼酸化合物通过铃木 交联法得到化学式34化合物; 使化学式34的化合物与甲苯磺酰化的亚烷基二醇单烷基醚反应以获得化学式35的化合物的步骤; 从化学式35的化合物中除去苄基以获得化学式36的化合物的步骤; 以及使化学式35和37的化合物与含卤素原子的盐的过渡金属化合物反应的步骤。
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公开(公告)号：KR1020080051285A
公开(公告)日：2008-06-11
申请号：KR1020060122077
申请日：2006-12-05
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
Abstract: A method for preparing metal oxide hollow nanocapsules is provided to produce the metal oxide hollow nanocapsules having excellent dispersibility in a water system and a uniform size distribution. A method for preparing metal oxide hollow nanocapsules includes the steps of: (a) dispersing metal oxyhydroxide particles in a mixture of water and alcohol to obtain a metal oxyhydroxide dispersion; (b) adding a silica precursor to the metal oxyhydroxide dispersion to form a silica coating layer on a metal oxyhydroxide particle by a sol-gel reaction; (c) heat-treating the metal oxyhydroxide having a silica coating layer to prepare the metal oxide hollow nanocapsules having a silica coating layer; and (d) removing the silica coating layer. Further, the metal oxyhydroxide is selected from akaganeite, boehmite, heterogenite, chromia aerogel, indium oxyhydroxide, manganite, nickel oxyhydroxide or tungsten oxyhydroxide.
Abstract translation: 提供了制备金属氧化物空心纳米胶囊的方法，以制备在水系中具有优异分散性和均匀尺寸分布的金属氧化物中空纳米胶囊。 制备金属氧化物空心纳米胶囊的方法包括以下步骤：（a）将金属羟基氧化物颗粒分散在水和醇的混合物中，得到氢氧化金属氢氧化物分散体; （b）将二氧化硅前体加入到羟基氧化金属分散体中，通过溶胶 - 凝胶反应在金属羟基氧化物颗粒上形成二氧化硅涂层; （c）对具有二氧化硅涂层的金属氢氧化物进行热处理以制备具有二氧化硅涂层的金属氧化物空心纳米胶囊; 和（d）除去二氧化硅涂层。 此外，金属氢氧化物选自菱铁矿，勃姆石，异质岩，氧化铬气凝胶，羟基氧化铟，亚锰酸盐，羟基氧化镍或羟基氧化钨。
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公开(公告)号：KR100846839B1
公开(公告)日：2008-07-16
申请号：KR1020060122077
申请日：2006-12-05
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
Abstract: 본 발명은 수계에 잘 분산되는 산화금속 중공 나노캡슐의 제조방법 및 이로부터 제조된 산화철 중공 나노캡슐에 관한 발명이다.
본 발명에 따른 산화금속 중공 나노캡슐의 제조방법은 금속 옥시수산화물 입자를 수계에 분산시킨 후 상기 금속 옥시수산화물 입자 상에 실리카 코팅층을 형성한 후 이를 열처리하여 실리카 코팅층 내부에 중공형의 산화금속층이 형성한 후 실리카를 제거하는 과정을 통해 이루어지는 것을 특징으로 한다. 본 발명의 제조방법에 의해 제조된 산화금속 중공 나노캡슐은 수계 분산성이 우수하고 균일한 입도분포를 가질 뿐만아니라 내부 중공에 생리 활성 물질을 담지할 수 있는 효과가 있다.
또한, 본 발명에 따른 산화철 나노캡슐은 100 m
2 /g 이상의 큰 표면적과 좁은 분포의 중형 기공(meso pore)을 지니고 있어 생리 활성 물질의 담지가 가능하며, 약물전달 같은 생명의학적 응용, 가스센서(gas sensor), 리튬 이온전지(Li ion battery) 등 광범위한 산업적 응용의 가능성을 기대할 수 있다.
금속 옥시수산화물, 중공 나노캡슐, 산화철-
Patent Agency Ranking
公开(公告)号：KR100809056B1
公开(公告)日：2008-03-03
申请号：KR1020060066439
申请日：2006-07-14
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 수용액 상에서 블록 공중합체를 이용하여 균일한 팔라듐 나노 입자를 제조하는 방법에 관한 것이다.
본 발명에 따른 제조방법에 의해 제조된 팔라듐 나노 입자는 그 조건에 따라서 몇 나노미터 에서 몇 십 나노미터 크기를 보이고 있으며, 입자의 크기 분포가 매우 균일하여 화학 반응의 촉매로 사용되어 높은 촉매 활성을 나타내는 장점이 있다.
블록 공중합체, 팔라듐 나노입자, 촉매-
公开(公告)号：KR1020080006996A
公开(公告)日：2008-01-17
申请号：KR1020060066439
申请日：2006-07-14
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: B22F9/24 , B22F2301/25 , B22F2304/054 , B82Y30/00 , B82Y40/00
Abstract: A preparation method of palladium nanoparticles is provided to obtain uniform size nanoparticles through a simplified process and at the same time, to diversify size and shape of the nanoparticles. A preparation method of palladium nanoparticles includes the steps of: dissolving a polyethylene oxide polypropyleneoxide-polyethyleneoxide block copolymer in a distilled water to produce a triblock copolymer solution; and adding and stirring (or agitating) a palladium (Pd) precursor compound into the triblock copolymer solution at 0.2-1 mole ratio. Further, the palladium precursor compound is added additionally to adjust size and shape of particles, and, an acid or a base is added into the triblock copolymer solution to adjust pH thereof.
Abstract translation: 提供钯纳米颗粒的制备方法以通过简化的方法获得均匀的尺寸的纳米颗粒，并且同时使纳米颗粒的尺寸和形状多样化。 钯纳米颗粒的制备方法包括以下步骤：将聚环氧乙烷聚环氧丙烷 - 聚环氧乙烷嵌段共聚物溶解在蒸馏水中以产生三嵌段共聚物溶液; 并以0.2-1摩尔比将钯（Pd）前体化合物加入并搅拌（或搅拌）到三嵌段共聚物溶液中。 此外，另外添加钯前体化合物以调节颗粒的尺寸和形状，并且在三嵌段共聚物溶液中加入酸或碱以调节其pH。
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公开(公告)号：KR100648618B1
公开(公告)日：2006-11-23
申请号：KR1020030082088
申请日：2003-11-19
Applicant: 주식회사 웰스킨 , 임동렬 , 재단법인서울대학교산학협력재단
IPC: C07F15/02
Abstract: 본 발명은 수퍼옥사이드 디스뮤타제(superoxide dismutase; 이하 'SOD') 및 카탈라제(catalase) 활성을 가지는 화합물 및 이를 유효성분으로 포함하는 활성산소 억제제에 관한 것으로, 본 발명의 활성 산소 소거능이 뛰어나고 독성이나 부작용이 적은 SOD 및 카탈라제 유도체 화합물은 피부 노화, 암, 치매, 류마티스 등의 활성산소와 관련된 질병의 예방 또는 치료용 약제 조성물 등의 제조에 이용될 수 있다.
활성 산소 억제제, 수퍼옥사이드 디스뮤타제(superoxide dismutase; 이하 'SOD'), 카탈라제(catalase)-
公开(公告)号：KR100846876B1
公开(公告)日：2008-07-16
申请号：KR1020070084853
申请日：2007-08-23
Applicant: 재단법인서울대학교산학협력재단
IPC: C07C15/16 , C07C49/303 , C07C15/18 , B82B3/00
Abstract: 본 발명은 수용액 상에서 블록 공중합체를 이용하여 균일한 팔라듐 나노 입자를 제조하는 방법 및 이로부터 제조된 팔라듐 나노입자를 스즈키 커플링 반응 촉매로 사용하는 것을 특징으로 하는 바이아릴 화합물의 제조방법에 관한 것이다.
본 발명에 따른 바이아릴 화합물의 제조방법은 적은 촉매 사용량 및 낮은 반응온도에서 높은 수율로 바이아릴 화합물을 제조할 수 있다.
블록 공중합체, 팔라듐 나노입자, 촉매-
公开(公告)号：KR1020080007195A
公开(公告)日：2008-01-17
申请号：KR1020070084853
申请日：2007-08-23
Applicant: 재단법인서울대학교산학협력재단
IPC: C07C15/16 , C07C49/303 , C07C15/18 , B82B3/00
Abstract: A method for preparing biaryl compounds is provided to produce biaryl compounds with high yield at low catalyst amount and low reaction temperature. A method for preparing biaryl compounds includes a step of using palladium nanoparticles as a Suzuki coupling reaction catalyst. The palladium nanoparticles are prepared by the steps of: (a) dissolving polyethyleneoxide-polypropyleneoxide-polyethyleneoxide block copolymers in distilled water to prepare a block copolymer solution; and (b) adding a palladium precursor compound to the block copolymer solution and stirring the admixture.
Abstract translation: 提供了一种制备联芳基化合物的方法，以低催化剂量和低反应温度产生高收率的联芳基化合物。 制备联芳基化合物的方法包括使用钯纳米颗粒作为Suzuki偶联反应催化剂的步骤。 通过以下步骤制备钯纳米颗粒：（a）将聚环氧乙烷 - 聚环氧丙烷 - 聚环氧乙烷嵌段共聚物溶解在蒸馏水中以制备嵌段共聚物溶液; 和（b）向嵌段共聚物溶液中加入钯前体化合物并搅拌混合物。
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