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公开(公告)号：KR101683344B1
公开(公告)日：2016-12-07
申请号：KR1020140145695
申请日：2014-10-27
Applicant: 숙명여자대학교산학협력단
IPC: A61K31/192 , A23L1/30
Abstract: 본발명은갱년기증상의예방또는개선용조성물에관한것으로, 더욱자세하게는유효성분으로서카르노식산화합물을포함하는갱년기또는폐경기의증상을예방및 개선을위한조성물(약제학적조성물, 식품조성물) 및이들조성물을포함하는건강기능식품과약제에관한것이다. 본발명에따른카르노식산(carnosic acid) 화합물은갱년기또는폐경기에나타나는에스트로겐감소에따른체중증대; 지방축적; 염증성사이토카인증대; 및인슐린, 렙틴, 트라이글리세라이드, 유리지방산의혈중수치증대를감소시키는효과가현저하다. 따라서본 발명의카르노식산(carnosic acid)은갱년기또는폐경기에나타나는증상을예방하거나, 치료하거나개선할수 있는물질로서약리학적조성물과같은의약품은물론이고, 기능성식품등으로활용할수 있어의약산업및 건강기능식품산업에응용될경우그 가치가매우높을것으로기대된다.
Abstract translation: 本发明涉及用于预防或改善绝经症状的组合物。 更具体地，本发明涉及包含鼠尾草酸化合物作为预防和改善绝经症状的有效成分的组合物（药物组合物，食品组合物），以及包含该组合物的保健食品和药物。 根据本发明，鼠尾草酸化合物在绝经过渡期间具有减少由雌激素降低引起的体重增加的优异效果; 脂肪积累 炎症细胞因子增加; 以及血液中胰岛素，瘦素，甘油三酯和游离脂肪酸水平的增加。 因此，根据本发明，鼠尾草酸是能够预防，治疗或改善更年期症状的材料，并且可用于保健功能性食品以及药物如药物组合物，因此预期是非常有价值的 适用于医疗行业和保健功能食品行业。
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公开(公告)号：KR101965699B1
公开(公告)日：2019-04-05
申请号：KR1020170171423
申请日：2017-12-13
Applicant: 숙명여자대학교산학협력단
IPC: A61K36/8962 , A23L33/105 , A61K45/06
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公开(公告)号：KR101370944B1
公开(公告)日：2014-03-12
申请号：KR1020110112768
申请日：2011-11-01
Applicant: 숙명여자대학교산학협력단
IPC: A61K36/886 , A61P29/00
Abstract: 본 발명은 알로인, 알로에신 또는 알로에 겔을 이용한 염증성 장 질환 개선제 조성물을 개시한다. 알로인, 알로에신 또는 알로에 겔은 DSS로 염증성 장 질환이 유도된 실험동물의 결장 점막 조직의 결실을 예방하는 효과를 가지며, 장 손상 동물 모델에서 염증 정도의 지표로 이용되는 미엘로퍼옥시다제의 활성을 낮추며, 염증 매개 물질인 류코트리엔 B4, TNF-α 및 PGE
2 혈장 농도를 낮출 뿐만 아니라 유전자 수준에서도 TNF-α와 IL-β의 발현을 억제하는 활성을 가지고 있다.-
公开(公告)号：KR101142759B1
公开(公告)日：2012-05-08
申请号：KR1020100012692
申请日：2010-02-11
Applicant: 숙명여자대학교산학협력단
IPC: A61K36/886 , A61P29/00
Abstract: PURPOSE: An agent for treating inflammatory bowel disease is provided to be used in manufacturing a drug or food. CONSTITUTION: A composition for treating inflammatory bowel diseases contains aloin as an active ingredient. The active ingredient is contained in 0.001-15 weight%. The composition is a pharmaceutical composition and a food composition. The food composition is beverage. The composition also contains 0.001-15 weight% of aloe gel as an active ingredient.
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公开(公告)号：KR1020110124743A
公开(公告)日：2011-11-17
申请号：KR1020110112768
申请日：2011-11-01
Applicant: 숙명여자대학교산학협력단
IPC: A61K36/886 , A61P29/00
CPC classification number: A61K36/886 , A23L33/105 , A23V2002/00 , A23V2200/308 , A23V2250/2102
Abstract: PURPOSE: A composition using aloin, aloesin, or aloe gel is provided to prevent deletion of colon mucosa and to lower leukotriene B4, TNF-alpha and PGE2 plasma concentration. CONSTITUTION: A composition for treating inflammatory bowel diseases contains aloesin as an active ingredient. The inflammatory bowel diseases are ulcerative colitis, crohn's disease, celiac disease, intestinal Behcet disease, celiac disease, or ischemic enteritis. The composition is a pharmaceutical composition or food composition. The pharmaceutical composition contains pharmaceutically acceptable carrier and excipient. The pharmaceutical composition is manufactured in the form of an oral formulation(tablet, suspension, granule, emulsion, capsule, syrup), parenteral formulaion(aqueous or oil suspension for sterilization infection), and topical formulation(solution, cream, ointment, gel, lotion, patch).
Abstract translation: 目的：提供使用芦荟，芦荟凝胶或芦荟凝胶的组合物，以防止结肠粘膜的缺失和降低白细胞三烯B4，TNF-α和PGE2血浆浓度。 构成：用于治疗炎症性肠病的组合物含有芦荟素作为活性成分。 炎症性肠病是溃疡性结肠炎，克罗恩病，腹腔疾病，肠内胆囊炎，腹腔疾病或缺血性肠炎。 组合物是药物组合物或食物组合物。 药物组合物含有药学上可接受的载体和赋形剂。 药物组合物以口服制剂（片剂，悬浮液，颗粒剂，乳剂，胶囊剂，糖浆剂），肠胃外制剂（用于灭菌感染的水性或油性悬浮液）和局部制剂（溶液，霜剂，软膏，凝胶， 洗剂，补丁）。
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Patent Agency Ranking
公开(公告)号：KR102002260B1
公开(公告)日：2019-07-19
申请号：KR1020180128660
申请日：2018-10-26
Applicant: 숙명여자대학교산학협력단
IPC: A61K36/8962 , A23L33/105 , A61K45/06 , A61P21/00
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公开(公告)号：KR1020160066724A
公开(公告)日：2016-06-13
申请号：KR1020140171849
申请日：2014-12-03
Applicant: 숙명여자대학교산학협력단
CPC classification number: C07H15/04 , Y10S435/853
Abstract: 본발명은글루코사민(glucosamine)을함유하여장내미생물분포균형을유지하고변비등 장기능이상을개선하는효과가있는기능성식품조성물에관한것이다. 본발명의글루코사민은동물실험에서변화된장내미생물균총분포를정상적인수준으로회복시켰으며, 여러장 질환의임상적증상을개선시키는효과가확인되었으므로, 변비나설사를예방또는완화시키는등 장기능을개선하는데유용하게사용될수 있다.
Abstract translation: 本发明涉及包含葡糖胺的功能性食品组合物，从而保持肠微生物菌群的分布平衡并改善诸如便秘的胃肠道功能障碍。 本发明的葡糖胺将动物实验中肠微生物菌群的分布变化恢复到正常水平，改善各种肠道疾病的临床症状，从而有效地用于改善肠功能，如预防或减轻便秘或腹泻等。
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公开(公告)号：KR1020160049312A
公开(公告)日：2016-05-09
申请号：KR1020140146262
申请日：2014-10-27
Applicant: 숙명여자대학교산학협력단
IPC: A61K31/7048 , A61K9/00 , A61K47/00
CPC classification number: A61K31/7048 , A61K9/0053 , A61K47/00
Abstract: 본발명은항암제부작용의경감용조성물에관한것이다. 본발명에따르면시아니딘-3-글루코시드를사용하여 5-플루오로우라실에의해발생하는염증반응과장손상, 골수억제(myelosuppression)와같은항암제부작용을효과적으로개선시킬수 있으며, 항암제로인해유발되는점막염및 면역억제의예방에효과적인치료제로적용할수 있다.
Abstract translation: 本发明涉及一种降低抗癌药副作用的组合物。 根据本发明，组合物能够有效地缓解抗癌药物的副作用，例如使用花青素-3-葡萄糖苷的5-氟尿嘧啶产生的炎性反应，肠损伤和骨髓抑制。 此外，该组合物可以用作预防免疫抑制和抗癌药物产生的粘膜炎的有效治疗剂。
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公开(公告)号：KR1020120072300A
公开(公告)日：2012-07-03
申请号：KR1020110035548
申请日：2011-04-18
Applicant: 숙명여자대학교산학협력단
IPC: A61K31/19 , A61K31/192 , A61K36/53 , A61P3/04
Abstract: PURPOSE: A composition and health functional food containing carnosic acid is provided to reduce the concentration of obesity-associated factors in blood and to relieve colon cancer development. CONSTITUTION: A composition for preventing or treating obesity or obesity-induced colon cancer contains carnosic acid as an active ingredient. The carnosic acid is extracted and isolated using water or organic solvent from rosemary. The organic solvent is alcohol of 1-4 carbon atoms, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, hexane, cyclo hexane, or a mixture solvent thereof. A health functional food for preventing or treating obesity or colon cancer induced from obesity contains the carnosic acid as an active ingredient.
Abstract translation: 目的：提供含有鼠尾草酸的组合物和保健功能食品，以减少血液中与肥胖有关的因素的浓度，并缓解结肠癌的发展。 构成：用于预防或治疗肥胖或肥胖诱导的结肠癌的组合物含有鼠尾草酸作为活性成分。 使用迷迭香的水或有机溶剂提取和分离鼠尾草酸。 有机溶剂是1-4个碳原子的醇，丙酮，乙醚，苯，氯仿，乙酸乙酯，二氯甲烷，己烷，环己烷或其混合溶剂。 用于预防或治疗由肥胖引起的肥胖症或结肠癌的健康功能食品含有鼠尾草酸作为活性成分。
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