Abstract:
PURPOSE: A pharmaceutical composition containing an alkoxy indole-3-acetic acid derivative is provided to prevent or treat obesity, diabetes, hyperlipidemia, hypertension, vascular diseases, cancer, and inflammatory diseases. CONSTITUTION: An alkoxy indole-3-acetic acid derivative is denoted by chemical formula 1. A compound of chemical formula 1a or 1b is prepared by coupling reaction of R3-(CH2)m-OH and a hydroxy idole compound of chemical formula 2a or 2b. A method for preparing 6-hydroxy indole compound of chemical formula 2a which is a starting material comprises; a step of substituting amine of 4-amino-3-nitro phenol of chemical formula 3 with iodine; a step of protecting hydroxy group of a compound of chemical formula 4 with benzyl group; a step of introducing methacrylate to a compound of chemical formula 5; a step of reducing a nitro group of a compound of chemical formula 6 with amine; a step of reacting a compound of chemical formula 7 with formyl acetate(AcOCHO) to obtain a compound of chemical formula 8; a step of reacting the compound of chemical formula 8 with triphosgen to obtain an isonitrile compound of chemical formula 9; a step of performing radical reaction of the compound of chemical formula 9 to obtain an indole compound of chemical formula 10; and a step of removing a benzyl group of the compound of chemical formula 10.