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公开(公告)号：KR100836559B1
公开(公告)日：2008-06-10
申请号：KR1020070008005
申请日：2007-01-25
Applicant: 신일제약주식회사
IPC: A61K31/70 , A61K36/896 , A61P29/00
Abstract: 본 발명은 염증성 질환 치료 및 예방에 유용한 녹제초 추출물에 관한 것으로서, 더욱 상세하게는 녹제초 추출물 중 알부틴(Arbutin)의 함량이 일정범위로 포함되도록 규격화 및 표준화시키고, 진통억제, 연골조직에 작용하는 귀부종 억제, 급성 염증억제, 염증 유발 물질의 발현 정도, 효소 p-p38 MAP 및 p-NFκB 단백질 발현양 억제 등의 염증성 변화에 의하여 나타나는 제증상의 억제 효과가 우수하게 발현되어 관절염 등의 염증성 변화에 의한 질환 치료 및 예방에 유용한 약제로 사용할 수 있는 녹제초 추출물에 관한 것이다.
녹제초, 관절염, 급성염증, 귀 부종, p-p38 MAP, p-NFκB, 알부틴-
公开(公告)号：KR1020070111034A
公开(公告)日：2007-11-21
申请号：KR1020060043855
申请日：2006-05-16
Applicant: 신일제약주식회사
CPC classification number: A61K36/63 , A61K2236/331 , A61K2236/333 , Y10S514/886
Abstract: Compositions comprising the extract of Osmanthus heterophylla are provided to inhibit pain, acute and chronic inflammation, acute and chronic edema caused by inflammatory changes through standardization of caffeine content in the Osmanthus heterophylla extract, thereby treating or preventing inflammatory diseases. A composition for treating or preventing inflammatory diseases comprises the extract of Osmanthus heterophylla containing 0.5-5.0 wt.% of caffeine as a marker, wherein the Osmanthus heterophylla extract is prepared by (1) extracting, cooling and filtering Osmanthus heterophylla with water, alcohol or alcohol solution, (2) inducing layer separation of the filtered solution with alcohol solution, and concentrating it at 60-70 deg.C under reduced pressure, and (3) adding alcohol into the concentrate, centrifuging the mixture at 500 to 1000 rpm, and vacuum-concentrating, vacuum-drying, pulverizing and sterilizing the filtered solution; and the inflammatory diseases include arthritis and edema.
Abstract translation: 提供了含有桂花提取物的组合物，用于通过标准化桂花提取物中的咖啡因含量来抑制疼痛，急性和慢性炎症，炎性变化引起的急性和慢性水肿，从而治疗或预防炎症性疾病。 用于治疗或预防炎性疾病的组合物包含含有0.5-5.0重量％的咖啡因作为标记物的桂花提取物，其中通过以下方法制备桂花异叶提取物：（1）用水，酒精提取，冷却和过滤桂花 酒精溶液，（2）用醇溶液诱导过滤溶液层分离，并在60-70℃减压浓缩，和（3）向浓缩物中加入酒精，以500至1000rpm离心该混合物， 真空浓缩，真空干燥，粉碎和灭菌过滤的溶液; 炎性疾病包括关节炎和水肿。
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公开(公告)号：KR1020070088984A
公开(公告)日：2007-08-30
申请号：KR1020060018934
申请日：2006-02-27
Applicant: 신일제약주식회사
Abstract: A medicine comprising an extract of Araliaceae including constant amount of folic acid is provided to inhibit acute and chronic inflammation or acute and chronic edema, thereby being useful for preventing and treating inflammatory diseases. The medicine for preventing and treating inflammatory diseases such as arthritis and edema comprises an extract of Araliaceae as powder which contains 0.01-0.1 wt.% of folic acid as an index material and is obtained by the method comprising the steps of: (a) extracting Araliaceae with water, alcohol, or an aqueous solution of alcohol, cooling, and filtering it; (b) after layer-separating the filtrate obtained from the step(a) using an aqueous solution of alcohol, concentrating it at a temperature of 60-80 deg.C under reduced pressure; and (c) after adding alcohol to the concentrate and centrifuging it with the speed of 500-1,000 rpm, concentrating it under reduced pressure, drying it under vacuum, pulverizing and sterilizing it.
Abstract translation: 提供一种包含含有恒定量叶酸的油菜科提取物的药物以抑制急性和慢性炎症或急性和慢性水肿，从而可用于预防和治疗炎症性疾病。 用于预防和治疗诸如关节炎和水肿的炎性疾病的药物包含作为粉末的芥子科的提取物，其含有0.01-0.1重量％的叶酸作为指标材料，并且通过包括以下步骤的方法获得：（a）提取 菊科与水，酒精或醇的水溶液，冷却并过滤; （b）使用醇的水溶液层析从步骤（a）得到的滤液后，在60〜80℃的温度下减压浓缩; （c）向浓缩液中加入酒精后，以500〜1000rpm的速度离心，减压浓缩，真空干燥，粉碎灭菌。
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公开(公告)号：KR1020080003701A
公开(公告)日：2008-01-08
申请号：KR1020070006239
申请日：2007-01-19
Applicant: 신일제약주식회사
CPC classification number: A61K36/24 , A61K2236/333 , A61K2236/51
Abstract: A pharmaceutical composition comprising an extract of Trachelospermi caulis is provided to exhibit excellent inhibitory activities against inflammatory symptoms such as inflammations and pains, expression of enzymes such as p-p38 MAP and p-NFkappaB, acute inflammation, and acute edema, thereby being effective for preventing and treating inflammatory diseases such as arthritis. A pharmaceutical composition for preventing and treating inflammatory diseases such as arthritis and edema comprises an extract of Trachelospermi caulis as an effective ingredient. A method for preparing the extract comprises the steps of: (a) extracting Trachelospermi caulis with a solvent selected from the group consisting of water, alcohol and an aqueous alcohol solution, cooling and filtering the extract; (b) after separating aqueous layers from the resulting filtrate, concentrating it at a temperature of 60-80 deg.C under reduced pressure; and (c) after adding alcohol to the obtained concentrate and centrifuging it with the speed of 500-1,000 rpm, concentrating it under reduced pressure, vacuum-drying the concentrate, and crushing and sterilizing the dried material.
Abstract translation: 提供了一种含有气管切片提取物的药物组合物，以显示出对诸如炎症和疼痛，诸如p-p38 MAP和p-NFkappaB等酶的表达，急性炎症和急性水肿等炎性症状的优异抑制活性，从而有效 预防和治疗炎性疾病如关节炎。 用于预防和治疗诸如关节炎和水肿的炎性疾病的药物组合物包含作为有效成分的气管切开提取物。 一种制备提取物的方法，包括以下步骤：（a）用选自水，醇和醇水溶液的溶剂萃取三氯气球，冷却并过滤提取物; （b）从所得滤液中分离水层后，在减压下将其浓缩至60-80℃; （c）向所得浓缩液中加入酒精后以500-1,000rpm的速度离心，减压浓缩，真空干燥浓缩物，并对干燥物进行粉碎和灭菌。
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Patent Agency Ranking
公开(公告)号：KR1020070089049A
公开(公告)日：2007-08-30
申请号：KR1020070008005
申请日：2007-01-25
Applicant: 신일제약주식회사
IPC: A61K31/70 , A61K36/896 , A61P29/00
CPC classification number: A61K31/7034 , A61K36/45 , A61K2236/51 , A61K2236/53 , Y10S514/825 , Y10S514/87 , Y10S514/886
Abstract: A medicine comprising an extract of Pyrola japonica Klenze containing constant amount of arbutin is provided to excellently inhibit pain, ear swelling acting on cartilage, acute and chronic inflammation, expression degree of inflammation inducing materials and expression amount of enzyme p-p38 MAP and p-NFkappaB protein so as to prevent and treat inflammatory diseases such as arthritis. The medicine for arthritis and edema comprises an extract of Pyrola japonica Klenze containing 0.1-1.0 wt.% of arbutin as an index material, wherein the extract of Pyrola japonica Klenze is obtained by (a) extracting Pyrola japonica Klenze with water, alcohol, or an aqueous solution of alcohol, cooling, and filtering it; (b) after layer-separating the filtrate obtained from the step(a) using an aqueous solution of alcohol, concentrating it at a temperature of 60-80 deg.C under reduced pressure; and (c) after adding alcohol to the concentrate and centrifuging it with the speed of 500-1,000 rpm, concentrating it under reduced pressure, drying it under vacuum, pulverizing and sterilizing it.
Abstract translation: 提供包含含有恒定量熊果苷的茯苓提取物的药物以极好地抑制疼痛，作用于软骨的耳肿胀，急性和慢性炎症，炎症诱导物质的表达程度和酶p-p38 MAP和p- NFkappaB蛋白，以预防和治疗炎性疾病如关节炎。 用于关节炎和水肿的药物包含含有0.1-1.0重量％的熊果苷作为指标材料的茯苓提取物，其中通过（a）用水，酒精或（ⅰ）提取extracting extracting is is is is is is is 酒精水溶液，冷却并过滤; （b）使用醇的水溶液层析从步骤（a）得到的滤液后，在60〜80℃的温度下减压浓缩; （c）向浓缩液中加入酒精后，以500〜1000rpm的速度离心，减压浓缩，真空干燥，粉碎灭菌。
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公开(公告)号：KR100847440B1
公开(公告)日：2008-07-21
申请号：KR1020070007616
申请日：2007-01-24
Applicant: 신일제약주식회사
CPC classification number: A61K36/185 , A61K36/24 , A61K2300/00
Abstract: A drug of herbal mixture is provided to alleviate pain, and inhibit chronic and acute inflammation, secretion of enzymes associated with inflammation, and production of NO(nitrogen oxide) and iNOs(inducible nitrogen oxide), so that the drug is useful for treating or preventing inflammatory diseases. A drug of herbal mixture containing extracts of Trachelospermi Caulis and Pyrola japonica contains 0.5-1.1 wt.% of arctiin, and is prepared by (1) mixing Trachelospermi Caulis and Pyrola japonica, extracting the mixture with water, alcohol or aqueous alcohol, and cooling and filtering the extract; (2) adding aqueous alcohol into the filtered solution to separate layers and concentrating the layer-separated solution at 60-80 deg. C under reduced pressure; and (3) adding alcohol into the concentrate, centrifuging the mixture at 500-1000 rpm, and vacuum concentrating, vacuum drying, pulverizing and sterilizing the centrifuged product. Further, the drug is useful for treating or preventing arthritis or oedema.
Abstract translation: 提供草药混合物以减轻疼痛，并且抑制慢性和急性炎症，与炎症相关的酶的分泌以及产生NO（氮氧化物）和iNO（可诱导的氮氧化物），使得该药物可用于治疗或 预防炎症性疾病。 含有川containing提取物和茯苓的草药混合物含有0.5-1.1％（重量）的arctiin，通过下列方法制备：（1）混合Tr is和Pyrola japonica，用水，醇或含水醇提取混合物，冷却 并过滤提取物; （2）将水醇加入到过滤的溶液中以分离层并将层分离的溶液在60-80℃浓缩。 C减压; 和（3）向浓缩物中加入酒精，以500-1000rpm离心该混合物，真空浓缩，真空干燥，对离心的产物进行粉碎和灭菌。 此外，该药物可用于治疗或预防关节炎或水肿。
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公开(公告)号：KR100847439B1
公开(公告)日：2008-07-21
申请号：KR1020070006239
申请日：2007-01-19
Applicant: 신일제약주식회사
CPC classification number: A61K36/24 , A61K2236/333 , A61K2236/51
Abstract: 본 발명은 낙석등(
Trachelospermi caulis) 추출물을 함유하는 염증성 질환 예방 및 치료용 약제에 관한 것으로서, 더욱 상세하게는 낙석등의 추출물 중 악틴(Arctiin)의 함량이 일정범위로 포함되도록 규격화 및 표준화시키고, 제제화하여, 진통 억제, 급성염증 억제, 효소 p-p38 MAP 및 p-NFκB 단백질 발현량 억제, 급성부종 억제 등의 염증성 변화에 의하여 나타나는 제증상의 억제 효과가 우수하게 발현되어 관절염 등의 염증성 질환 예방 및 치료에 유효한 낙석등 추출물을 함유하는 약제에 관한 것이다.
낙석등, 관절염, 급성염증, 진통, 급성부종, 악틴, p-p38 MAP, p-NFκB-
公开(公告)号：KR100779026B1
公开(公告)日：2007-11-28
申请号：KR1020060043855
申请日：2006-05-16
Applicant: 신일제약주식회사
Abstract: 본 발명은 염증성 질환 치료 및 예방에 유용한 구골 추출물에 관한 것으로서, 더욱 상세하게는 구골의 추출물 중 카페인의 함량이 일정범위로 포함되도록 규격화 및 표준화시키고, 진통억제, 급성염증억제, 만성염증억제, 급성부종억제 및 만성부종억제 등의 염증성 변화에 의하여 나타나는 제증상의 억제 효과가 우수하게 발현되어 관절염 등의 염증성 변화에 의한 질환 치료 및 예방에 유용한 약제로 사용할 수 있는 구골 추출물에 관한 것이다.
구골, 관절염, 급성염증, 급성부종, 카페인(Caffein)-
公开(公告)号：KR1020070088940A
公开(公告)日：2007-08-30
申请号：KR1020060018833
申请日：2006-02-27
Applicant: 신일제약주식회사
Abstract: Provided is a medicine comprising an extract of Amaranthaceae having constant amount of succinic acid which shows excellent inhibitory effect on various symptoms such as pain inhibition, acute inflammation inhibition, chronic inflammation inhibition, acute edema inhibition and chronic edema inhibition so as to be usefully used for preventing and treating inflammatory diseases. The medicine for preventing and treating inflammatory diseases comprises an extract of Amaranthaceae which contains 0.5-5.0 wt.% of succinic acid as an index material. The extract is obtained by the method comprising the steps of: (a) extracting Amaranthaceae with water, alcohol, or an aqueous solution of alcohol, cooling, and filtering it; (b) after layer-separating the filtrate obtained from the step (a) using an aqueous solution of alcohol, concentrating it at a temperature of 60-80 deg.C under reduced pressure; and (c) after adding alcohol to the concentrate and centrifuging it with the speed of 500-1,000 rpm, concentrating it under reduced pressure, drying it under vacuum, pulverizing and sterilizing it.
Abstract translation: 本发明提供一种药物，其含有具有一定量的琥珀酸的苋科植物提取物，其对各种症状（例如疼痛抑制，急性炎症抑制，慢性炎症抑制，急性水肿抑制和慢性水肿抑制）具有优异的抑制作用，以有效地用于 预防和治疗炎性疾病。 用于预防和治疗炎性疾病的药物包括含有0.5-5.0重量％琥珀酸作为指标材料的苋科植物提取物。 通过包括以下步骤的方法获得提取物：（a）用水，醇或醇的水溶液萃取苋菜，冷却并过滤; （b）使用醇的水溶液层析从步骤（a）得到的滤液后，在60〜80℃的温度下减压浓缩; （c）向浓缩液中加入酒精后，以500〜1000rpm的速度离心，减压浓缩，真空干燥，粉碎灭菌。
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