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公开(公告)号:KR1020130028012A
公开(公告)日:2013-03-18
申请号:KR1020120099149
申请日:2012-09-07
Applicant: 신풍제약주식회사
IPC: A61K31/728 , A61K9/06 , A61K9/08 , A61P19/02
CPC classification number: A61K9/0019 , A61K31/728 , A61K31/738 , A61K47/36
Abstract: PURPOSE: A therapeutic injection agent for arthritis is provided to ensure excellent physical property and long-term persistence. CONSTITUTION: A therapeutic injection agent for treating or relieving arthritis contains 0.4-3.0 (w/w)% of hydrogel which is prepared by crosslinking of hyaluronic acid and alkylene diamine. The alkylene diamine is hexamethylene diamine. The composition further contains hyaluronic acid.
Abstract translation: 目的:提供用于关节炎的治疗注射剂,以确保优异的物理性能和长期持久性。 构成:用于治疗或缓解关节炎的治疗注射剂含有通过透明质酸和亚烷基二胺的交联制备的0.4-3.0(w / w)%的水凝胶。 亚烷基二胺是六亚甲基二胺。 组合物还含有透明质酸。
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公开(公告)号:KR1020120006451A
公开(公告)日:2012-01-18
申请号:KR1020110068627
申请日:2011-07-11
Applicant: 신풍제약주식회사 , 포항공과대학교 산학협력단
CPC classification number: A61K8/735 , A61K31/167 , A61L27/20 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2400/06 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
Abstract: PURPOSE: A filler composition for reinforcing tissue and a manufacturing method thereof are provided to be injected into biological tissue by being charged with injections easily to maintain the characteristic including viscoelasticity, and the like steadily after sterilization, and to enhance biocompatibility. CONSTITUTION: A filler composition for reinforcing tissue includes a hyaluronic acid of the following equation and a hydro gel of alkylendiamine crosslinking materials The equation is expressed as [HA]m-C(O)-NH-R1-NH-C(O)-[HA]n, wherein HA indicates the hyaluronic acid except a carboxyl group or its salt, R1 shows hydroxyl group, and C1-C6 indicate alkyl group, C3-C10 alkylene functional group which is substituted as C1-C6 alkoxy, or which is non-subjstituted, and m and n indicate integer ranged 10,000-4,000,000. The molecular weight of the hyaluronic acid is from 20,000 to 40,000 dalton.
Abstract translation: 目的:提供一种用于增强组织的填充剂组合物及其制造方法,其通过在灭菌后容易地维持包括粘弹性等特性等特性的注射剂注入生物体组织,并提高生物相容性。 构成:用于增强组织的填充剂组合物包括以下等式的透明质酸和烷基二胺交联材料的水凝胶。该方程式表示为[HA] mC(O)-NH-R 1 -NH-C(O) - [HA ] n,其中HA表示除了羧基或其盐以外的透明质酸,R1表示羟基,C1-C6表示烷基,作为C1-C6烷氧基取代的C3-C10亚烷基官能团, 取代,m和n表示整数范围为10,000-4,000,000。 透明质酸的分子量为20,000至40,000道尔顿。
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公开(公告)号:KR101400907B1
公开(公告)日:2014-06-10
申请号:KR1020110068627
申请日:2011-07-11
Applicant: 신풍제약주식회사 , 포항공과대학교 산학협력단
CPC classification number: A61K8/735 , A61K31/167 , A61L27/20 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2400/06 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
Abstract: 본 발명은 히알루론산 및 알킬렌디아민 가교물 하이드로겔을 포함하는 조직증강용 충전제에 관한 것으로, 생체 적합성 및 팽윤성 등 조직증강에 필요한 물성이 우수하고 생체내에서 오래 지속될 수 있어 그 교환횟수를 줄일 수 있는 유리한 효과를 나타낼 수 있다.
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