公开(公告)号：KR1020100057423A

公开(公告)日：2010-05-31

申请号：KR1020080116461

申请日：2008-11-21

Applicant: 신풍제약주식회사

Inventor： 김기원 ,  노정열 ,  윤지상 ,  강신철 ,  정현규 ,  주태영

IPC: A61K47/48 ,  A61K31/192 ,  A61K47/06

CPC classification number: A61K31/192 ,  A61K9/0053 ,  A61K47/02 ,  A61K47/183

Abstract: PURPOSE: A method for preparing dexibuprofen salt and a pharmaceutical composition for oral administration containing the same are provided to enhance release rate and to reduce side effect. CONSTITUTION: A method for preparing a dexibuprofen salt comprises: a step of dissolving dexibuprofen and inorganic base or organic base in two kinds of more polar solvent; a step of adding acetone to crystallize; and a step of drying crystal. The inorganic base or organic base is arginine, lysine, histidine, ornithine, NH4OH, NaOH, or KOH. A pharmaceutical composition contains the dexibuprofen salt and pharmaceutically acceptable carrier. A pharmaceutical composition for oral administration is used in the form of tablet, capsule, granule, pill, or liquid.

Abstract translation: 目的：提供一种制备右旋布洛芬盐的方法和含有这些组合物的用于口服给药的药物组合物以提高释放速率并降低副作用。 构成：一种制备右布洛芬盐的方法，其特征在于，将二苯丙酮酸和无机碱或有机碱溶解在两种极性较大的溶剂中的步骤; 加入丙酮结晶的步骤; 以及干燥晶体的步骤。 无机碱或有机碱是精氨酸，赖氨酸，组氨酸，鸟氨酸，NH 4 OH，NaOH或KOH。 药物组合物含有对映布洛芬盐和药学上可接受的载体。 用于口服给药的药物组合物以片剂，胶囊剂，颗粒剂，丸剂或液体的形式使用。