公开(公告)号：KR102049091B1

公开(公告)日：2019-11-26

申请号：KR1020130029706

申请日：2013-03-20

Applicant: 신풍제약주식회사

Inventor： 유제만 ,  이동원 ,  정현규 ,  류황권 ,  차명종 ,  박진헌

IPC: C07D471/04 ,  C07D401/14 ,  A61K31/519 ,  A61K31/42

公开(公告)号：KR1020140115085A

公开(公告)日：2014-09-30

申请号：KR1020130029706

申请日：2013-03-20

Applicant: 신풍제약주식회사

Inventor： 유제만 ,  이동원 ,  정현규 ,  류황권 ,  차명종 ,  박진헌

IPC: C07D471/04 ,  C07D413/14 ,  A61K31/519 ,  A61P25/00

Abstract: Disclosed is a new method for manufacturing paliperidone with high purity and high yield. According to the present invention palperidone with high purity of 99.85-99.9% and high yield of 85-90% can be manufactured and refined, and moreover, paliperidone having content of specific impurities controlled to be lower than 0.1%. Disclosed is a method for manufacturing paliperidone is characterized by comprising the steps of manufacturing crude paliperidone; manufacturing paliperidone hydrochloride; and conversing into paliperidone.

Abstract translation: 公开了一种制备高纯度和高产率的利培酮的新方法。 根据本发明，可以制造和精制具有99.85-99.9％的高纯度和85-90％的高纯度的哌啶酮，此外，具有特定杂质含量的帕培酮控制在低于0.1％。 本发明公开了一种制备利培酮的方法，其特征在于包括以下步骤：制备普拉酮; 制造盐酸利培酮; 并交谈利培酮。