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公开(公告)号：KR1020150051429A
公开(公告)日：2015-05-13
申请号：KR1020130132866
申请日：2013-11-04
Applicant: 아주대학교산학협력단
IPC: A61K31/35 , A61K31/352 , A61P3/04 , A61P3/00
Abstract: 본발명은항비만효과를나타내는로테논을함유한조성물에관한것으로, 보다자세하게는로테논은고과당및 고지방섭취에의한식이성비만에서지방세포의크기와지방량을줄이고, 지방간축적을억제하는효과를나타냈기때문에, 본발명에따른로테논조성물은식이성비만을줄이는데탁월한효능을나타내어비만의예방또는치료에유용하게사용할수 있다.
Abstract translation: 本发明涉及具有抗肥胖效果的含有鱼藤酮的组合物。 更具体地，本发明的鱼藤酮组合物可用于预防或治疗肥胖症，因为鱼藤酮具有通过摄取高果糖和高脂肪而引起的膳食肥胖中减少脂肪细胞的尺寸的作用，并抑制脂肪蓄积 肝。
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2.发明授权
公开(公告)号：KR101121954B1
公开(公告)日：2012-03-09
申请号：KR1020100045116
申请日：2010-05-13
Applicant: 아주대학교산학협력단
IPC: A61K31/194 , A61K31/19 , A61P3/10 , A61P3/00
Abstract: 본발명은항당뇨효과를갖는 1,2,3-Benzentricarboxylic acid(이하‘BTA’라한다)의사용용도에관한것이다. 당뇨병발생모델생쥐인 C57BLKS/J- db/db에 BTA를 4주간투여시탁월한혈당강하효능을나타내었다. 특히 BTA를투여한 db/db 생쥐군에서인슐린을분비하는췌장의베타세포는파괴되지않고보존되는효과가나타났다. 즉, BTA는혈당강하, 베타세포보전, 포도당자극인슐린분비증가에뚜렷한효능이있었으므로 BTA는당뇨병예방또는당뇨병치료용조성물로사용할수 있을것으로사료된다.
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公开(公告)号：KR1020090121944A
公开(公告)日：2009-11-26
申请号：KR1020080048118
申请日：2008-05-23
Applicant: 아주대학교산학협력단
Abstract: PURPOSE: A composition containing marine microorganism metabolite for preventing and treating diabetes is provided to ensure excellent efficiency in suppressing vascular endothelial cell apoptosis and inflammation. CONSTITUTION: A composition for preventing and treating diabetes contains marine microorganism metabolite as an active ingredient. The marine microorganism is Chromohalobacter salexigens(KCTC 11333BP). The marine microorganism is isolated using hexane solvent. A method for producing the composition for preventing and treating diabetes comprises: a step of culturing the marine microorganism strain; a step of isolating the strain using the solvent; a step of concentrating the microorganism metabolite; and a step of isolating the concentrated metabolite.
Abstract translation: 目的：提供含有用于预防和治疗糖尿病的海洋微生物代谢物的组合物，以确保抑制血管内皮细胞凋亡和炎症的优异效果。 构成：用于预防和治疗糖尿病的组合物含有海洋微生物代谢物作为活性成分。 海洋微生物是沙门菌（KCTC 11333BP）。 使用己烷溶剂分离海洋微生物。 糖尿病预防和治疗用组合物的制造方法包括：培养海洋微生物菌株的工序; 使用溶剂分离菌株的步骤; 浓缩微生物代谢物的步骤; 和分离浓缩代谢物的步骤。
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公开(公告)号：KR101706868B1
公开(公告)日：2017-02-16
申请号：KR1020150159132
申请日：2015-11-12
Applicant: 아주대학교산학협력단
IPC: A61K31/19 , A61K31/195 , A61K31/198 , A23L1/30
Abstract: 본발명은 2-아미노-2-노보네인카복실산(2-amino-2-norbornane carboxylic acid, BCH)을함유하는지방간염, 특히고지방및 고과당식이로인하여유도된비알콜성지방간염(NASH)의예방, 치료또는개선용조성물에관한것이다. 상기 2-아미노-2-노보네인카복실산은염증반응억제, 간조직섬유화억제, 간세포사멸억제등의효능을발휘하므로, 간세포손상을억제하고 NASH를예방또는치료하기위한약학적또는식품조성물로사용할수 있다.
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Patent Agency Ranking
公开(公告)号：KR101514422B1
公开(公告)日：2015-04-24
申请号：KR1020080046434
申请日：2008-05-20
Applicant: 아주대학교산학협력단
Abstract: 본 발명은 해양미생물 대사체를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 조성물에 관한 것으로, 더욱 상세하게는 베타세포 사멸억제에 탁월한 효과를 가지는 당뇨병 예방 또는 치료용 조성물에 관한 것이다.
베타세포, 해양 미생물, 지방산 독성, 당뇨병-
公开(公告)号：KR1020150026510A
公开(公告)日：2015-03-11
申请号：KR1020130105475
申请日：2013-09-03
Applicant: 아주대학교산학협력단
IPC: A61K31/198 , A61P3/04 , A61P3/00
Abstract: 본 발명은 2-아미노-2-노보네인카르복실산을 함유하는 비만 예방 또는 치료용 조성물에 관한 것으로, 보다 자세하게는 2-아미노-2-노보네인카르복실산이 식이성 비만에서 지방세포의 분화를 억제하고 지방세포의 양을 줄이는 효과를 나타냈기 때문에, 본 발명에 따른 2-아미노-2-노보네인카르복실산 조성물은 고지방 및 고과당에 의한 식이성 비만을 줄이는데 탁월한 효능을 나타낼 수 있기 때문에 식이성 비만의 예방 또는 치료에 유용하게 사용할 수 있다.
Abstract translation: 本发明涉及包含用于预防或治疗肥胖症的2-氨基-2-去羰甲酸的组合物。 更具体地，作为2-氨基-2-去羰甲酸具有抑制饮食诱导的肥胖中的脂肪细胞分化和减少脂肪细胞的量的效果，根据本发明的2-氨基-2-去羰基羧酸的组成可以 显示出由于高脂肪和高糖而降低膳食诱导的肥胖的极好效果，从而能够有效地用于预防或治疗饮食诱导的肥胖症。
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8.发明公开4-(1Ｈ-인다졸-6-일아미노)-Ｎ-아이소프로필-2-(메틸티오)피리미딘-5-카르복스아미드 화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 당뇨병 예방 또는 치료용 조성물 有权含有4-1H-吲唑-6-基氨基-N-异丙基-2-甲硫基嘧啶-5-甲酰胺或其药学上可接受的盐的糖尿病预防或治疗组合物
公开(公告)号：KR1020120133633A
公开(公告)日：2012-12-11
申请号：KR1020110052370
申请日：2011-05-31
Applicant: 아주대학교산학협력단 , 동화약품주식회사
IPC: A61K31/505 , A61K31/416 , A61P3/10 , A61P3/00
CPC classification number: A61K31/506 , A23L33/10 , A61K31/416 , Y10S514/866
Abstract: PURPOSE: A pharmaceutical composition containing 4-(1H-indazole-6-ylamino)-N-isopropyl-2-(methylthio)pyrimidine-5-carboxamide compounds is provided to suppress beta cell apoptosis and to control blood glucose. CONSTITUTION: A pharmaceutical composition for preventing or treating diabetes contains 4-(1H-indazole-6-ylamino)-N-isopropyl-2-(methylthio)pyrimidine-5-carboxamide compounds of chemical formula 1 or pharmaceutically acceptable salts thereof. A health functional food for preventing or treating diabetes contains the compound of chemical formula 1 or salts. A method for preparing the compound of chemical formula 1 comprises: a step of reacting 6-aminoindazole with 4-chloro-2-methylthio-5-pyrimidine carboxylic acid ethyl ester under the presence of a base to prepare 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester; a step of hydrating the 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester to prepare 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid; and a step of reacting isopropyl amine with 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid.
Abstract translation: 目的：提供含有4-（1H-吲唑-6-基氨基）-N-异丙基-2-（甲硫基）嘧啶-5-甲酰胺化合物的药物组合物，以抑制β细胞凋亡并控制血糖。 构成：用于预防或治疗糖尿病的药物组合物含有化学式1的4-（1H-吲唑-6-基氨基）-N-异丙基-2-（甲硫基）嘧啶-5-甲酰胺化合物或其药学上可接受的盐。 用于预防或治疗糖尿病的健康功能食品含有化学式1或其盐的化合物。 制备化学式1的化合物的方法包括：在碱的存在下使6-氨基吲唑与4-氯-2-甲硫基-5-嘧啶羧酸乙酯反应，制备4-（1H-吲唑-2-基） 吡啶-6-基氨基）-2-（甲硫基）嘧啶-5-甲酸乙酯; 水化4-（1H-吲唑-6-基氨基）-2-（甲硫基）嘧啶-5-甲酸乙酯以制备4-（1H-吲唑-6-基氨基）-2-（甲硫基）嘧啶 -5-羧酸 和异丙胺与4-（1H-吲唑-6-基氨基）-2-（甲硫基）嘧啶-5-甲酸反应的步骤。
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9.发明公开
公开(公告)号：KR1020110125537A
公开(公告)日：2011-11-21
申请号：KR1020100045116
申请日：2010-05-13
Applicant: 아주대학교산학협력단
IPC: A61K31/194 , A61K31/19 , A61P3/10 , A61P3/00
Abstract: PURPOSE: A composition containing antibacterial 1,2,3-Benzentricarboxylic acid(BTA) is provided to preserve pancreatic beta cells and to reduce blood glucose. CONSTITUTION: A pharmaceutical composition for preventing or treating diabetes contains 1,2,3-Benzentricarboxylic acid(BTA) as an active ingredient. The effective amount of the compound is 0.001-10 g/kg body weight. The diabetes is type 2 diabetes. A food composition for relieving diabetes contains 1,2,3-Benzentricarboxylic acid(BTA) as an active ingredient. A feed composition for preventing or treating diabetes contains 1,2,3-Benzentricarboxylic acid(BTA) as an active ingredient.
Abstract translation: 目的：提供含有抗菌1,2,3-苯三羧酸（BTA）的组合物以保留胰腺β细胞并降低血糖。 构成：用于预防或治疗糖尿病的药物组合物含有1,2,3-苯三甲酸（BTA）作为活性成分。 化合物的有效量为0.001-10g / kg体重。 糖尿病是2型糖尿病。 用于缓解糖尿病的食物组合物含有1,2,3-苯三羧酸（BTA）作为活性成分。 用于预防或治疗糖尿病的饲料组合物含有1,2,3-苯三甲酸（BTA）作为活性成分。
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公开(公告)号：KR1020100128600A
公开(公告)日：2010-12-08
申请号：KR1020090047089
申请日：2009-05-28
Applicant: 아주대학교산학협력단
CPC classification number: C12P7/6409 , C12N1/20 , C12P7/62
Abstract: PURPOSE: A method for producing 9Z-hexadecenoic acid from Halomonas is provided to improve yield and to optimize isolation and purification of 9Z-Hexadecenoic acid. CONSTITUTION: A method for producing 9Z-Hexadecenoic acid comprises: a step of culturing Halomonas sp. marine microorganism strain; and a step of isolating a metabolite of the cultured strain and concentrating. The Halomonas sp. marine microorganism stain is Halomonas CCRB608(KCTC 11313BP). A method further comprises a chromatography.
Abstract translation: 目的：提供从卤代物制备9Z-十六碳烯酸的方法，以提高产量并优化9Z-十六碳烯酸的分离和纯化。 构成：生产9Z-十六碳烯酸的方法包括：培养卤菌素 海洋微生物菌株; 并分离培养菌株的代谢物并浓缩的步骤。 卤虫属 海洋微生物染色是Halomonas CCRB608（KCTC 11313BP）。 方法还包括色谱法。
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