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公开(公告)号：KR101514423B1
公开(公告)日：2015-04-23
申请号：KR1020080048118
申请日：2008-05-23
Applicant: 아주대학교산학협력단
Abstract: 본 발명은 당뇨합병증을 예방 또는 치료하는 조성물에 관한 것으로, 더욱 상세하게는 해양 미생물 대사체를 유효성분으로 하는 당뇨합병증을 예방 또는 치료하는 조성물에 관한 것이다. 본 발명의 해양 미생물 대사체는 지방독성에 의한 혈관내피세포 사멸 및 염증반응 억제에 탁월한 효능을 나타내어 당뇨합병증의 대표적인 인 동맥경화증을 억제하는데 효과가 있음을 확인하였다.
혈관내피세포, 당뇨병성 합병증, 동맥경화증-
公开(公告)号：KR101514422B1
公开(公告)日：2015-04-24
申请号：KR1020080046434
申请日：2008-05-20
Applicant: 아주대학교산학협력단
Abstract: 본 발명은 해양미생물 대사체를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 조성물에 관한 것으로, 더욱 상세하게는 베타세포 사멸억제에 탁월한 효과를 가지는 당뇨병 예방 또는 치료용 조성물에 관한 것이다.
베타세포, 해양 미생물, 지방산 독성, 당뇨병-
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公开(公告)号：KR101086866B1
公开(公告)日：2011-11-25
申请号：KR1020107001302
申请日：2008-06-26
Applicant: 아주대학교산학협력단
CPC classification number: C12R1/07 , A61K35/742
Abstract: 본 발명은 해양 미생물 추출물을 함유하는 항암 조성물에 관한 것으로, 더욱 상세하게는 바실러스 균주 추출물을 함유하는 항암 조성물에 관한 발명이다.
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Patent Agency Ranking
公开(公告)号：KR1020100001756A
公开(公告)日：2010-01-06
申请号：KR1020080061796
申请日：2008-06-27
Applicant: 아주대학교산학협력단
Abstract: PURPOSE: A composition for anticancer containing marine microorganism extract is provided to suppress penetration and proliferation of cancer and induce apoptosis. CONSTITUTION: A composition for anticancer contains Pseudomonas sp. extract as an active ingredient. The cancer is head and neck cancer, oral cancer, colorectal cancer, stomach cancer and liver cancer. The Pseudomonas sp. is Pseudoalteromonas sp.(KCTC11358BP). The mechanism of anticancer is performed through apoptosis or necrosis.
Abstract translation: 目的：提供含有海洋微生物提取物抗癌剂的组合物，以抑制癌细胞的侵袭和增殖，诱导细胞凋亡。 构成：抗癌组合物含有假单胞菌属 提取物作为活性成分。 癌症是头颈癌，口腔癌，结肠直肠癌，胃癌和肝癌。 假单胞菌属 是假型短单胞菌属（KCTC11358BP）。 抗癌机制是通过细胞凋亡或坏死进行的。
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公开(公告)号：KR1020090121944A
公开(公告)日：2009-11-26
申请号：KR1020080048118
申请日：2008-05-23
Applicant: 아주대학교산학협력단
Abstract: PURPOSE: A composition containing marine microorganism metabolite for preventing and treating diabetes is provided to ensure excellent efficiency in suppressing vascular endothelial cell apoptosis and inflammation. CONSTITUTION: A composition for preventing and treating diabetes contains marine microorganism metabolite as an active ingredient. The marine microorganism is Chromohalobacter salexigens(KCTC 11333BP). The marine microorganism is isolated using hexane solvent. A method for producing the composition for preventing and treating diabetes comprises: a step of culturing the marine microorganism strain; a step of isolating the strain using the solvent; a step of concentrating the microorganism metabolite; and a step of isolating the concentrated metabolite.
Abstract translation: 目的：提供含有用于预防和治疗糖尿病的海洋微生物代谢物的组合物，以确保抑制血管内皮细胞凋亡和炎症的优异效果。 构成：用于预防和治疗糖尿病的组合物含有海洋微生物代谢物作为活性成分。 海洋微生物是沙门菌（KCTC 11333BP）。 使用己烷溶剂分离海洋微生物。 糖尿病预防和治疗用组合物的制造方法包括：培养海洋微生物菌株的工序; 使用溶剂分离菌株的步骤; 浓缩微生物代谢物的步骤; 和分离浓缩代谢物的步骤。
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公开(公告)号：KR1020100066433A
公开(公告)日：2010-06-17
申请号：KR1020107001302
申请日：2008-06-26
Applicant: 아주대학교산학협력단
CPC classification number: C12R1/07 , A61K35/742
Abstract: PURPOSE: An anticancer composition containing marine microorganism extract is provided to ensure anticancer effect of various cell lines and to induce apoptosis of the cancer cells. CONSTITUTION: An anticancer composition contains Bacillus sp. strain extract as an active ingredient. The cancer is head and neck cancer, stomach cancer, liver cancer, colon cancer, lung cancer, or melanoma. The Bacillus sp. strain is Bacillus sp. SW31(KCTC 11135BP). The anticancer composition is administered together with conventional therapy for cancer. The conventional therapy is surgical operation, chemical therapy, radiation therapy, or immune therapy.
Abstract translation: 目的：提供含有海洋微生物提取物的抗癌组合物，以确保各种细胞系的抗癌作用，并诱导癌细胞凋亡。 构成：抗癌组合物含有芽孢杆菌属。 应变提取物作为活性成分。 癌症是头颈癌，胃癌，肝癌，结肠癌，肺癌或黑素瘤。 芽孢杆菌 菌株是芽孢杆菌属。 SW31（KCTC 11135BP）。 抗癌组合物与常规的癌症治疗一起施用。 常规治疗是外科手术，化疗，放射治疗或免疫治疗。
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公开(公告)号：KR1020100128600A
公开(公告)日：2010-12-08
申请号：KR1020090047089
申请日：2009-05-28
Applicant: 아주대학교산학협력단
CPC classification number: C12P7/6409 , C12N1/20 , C12P7/62
Abstract: PURPOSE: A method for producing 9Z-hexadecenoic acid from Halomonas is provided to improve yield and to optimize isolation and purification of 9Z-Hexadecenoic acid. CONSTITUTION: A method for producing 9Z-Hexadecenoic acid comprises: a step of culturing Halomonas sp. marine microorganism strain; and a step of isolating a metabolite of the cultured strain and concentrating. The Halomonas sp. marine microorganism stain is Halomonas CCRB608(KCTC 11313BP). A method further comprises a chromatography.
Abstract translation: 目的：提供从卤代物制备9Z-十六碳烯酸的方法，以提高产量并优化9Z-十六碳烯酸的分离和纯化。 构成：生产9Z-十六碳烯酸的方法包括：培养卤菌素 海洋微生物菌株; 并分离培养菌株的代谢物并浓缩的步骤。 卤虫属 海洋微生物染色是Halomonas CCRB608（KCTC 11313BP）。 方法还包括色谱法。
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公开(公告)号：KR1020090120560A
公开(公告)日：2009-11-25
申请号：KR1020080046434
申请日：2008-05-20
Applicant: 아주대학교산학협력단
CPC classification number: A61K35/66 , A23L33/135 , A23V2002/00 , A23V2200/328 , Y10S514/866
Abstract: PURPOSE: A composition for preventing or treating diabetes, which contains marine microorganism metabolite is provided to ensure the effect of suppressing beta cell death with low price. CONSTITUTION: A composition for preventing or treating diabetes contains marine microorganism metabolite as an active ingredient. The marine microorganism is Halomonas sp. The microorganism is Halomonas CCRB608(KCTC 11313BP). The marine microorganism metabolite is extracted using methanol and hexane solvent. A method for producing the composition comprises: a step of culturing marine microorganism strain; a step of extracting cultured strain using solvent; a step of concentrating the extracted marine microorganism metabolite; and a step of isolating concentrated metabolite.
Abstract translation: 目的：提供一种预防或治疗含有海洋微生物代谢物的糖尿病组合物，以确保以低价格抑制β细胞死亡的效果。 构成：用于预防或治疗糖尿病的组合物含有海洋微生物代谢物作为活性成分。 海洋微生物是Halomonas sp。 该微生物是Halomonas CCRB608（KCTC 11313BP）。 使用甲醇和己烷溶剂萃取海洋微生物代谢物。 制备该组合物的方法包括：培养海洋微生物菌株的步骤; 使用溶剂提取培养菌株的步骤; 浓缩提取的海洋微生物代谢物的步骤; 和分离浓缩代谢物的步骤。
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