公开(公告)号：KR100840132B1

公开(公告)日：2008-06-23

申请号：KR1020070037619

申请日：2007-04-17

Applicant: 재단법인서울대학교산학협력재단

Inventor： 주준호 ,  신내철 ,  김화용 ,  이윤우

IPC: C07D501/59 ,  B01D11/00

Abstract: A method for drying cefpodoxime proxetil is provided to obtain the cefpodoxime proxetil with almost no remaining solvent with reduced cost and drying time by performing a drying process using a saturated liquid CO2, which is relatively cheap, harmless to human body and non-reactive with a product. A method for drying cefpodoxime proxetil comprises a step of removing at least one remaining organic solvent selected from the group consisting of diisopropylether, ethyl acetate and dichloromethane by circulating saturated liquid carbon dioxide using a reboiler and a condenser without using a power unit such as a pump during a process of preparing the cefpodoxime proxetil.

Abstract translation: 提供了一种干燥头孢泊肟原料的方法，通过使用相对便宜的对人体无害的并且与人体无反应的饱和液体CO 2进行干燥处理，几乎没有残留的溶剂，几乎没有残留的溶剂，从而获得头孢泊肟几乎没有残留的溶剂 产品。 用于干燥头孢泊肟原料的方法包括通过使用再沸器和冷凝器循环饱和液体二氧化碳除去至少一种选自二异丙醚，乙酸乙酯和二氯甲烷的剩余有机溶剂的步骤，而不使用动力单元如泵 在制备头孢泊肟原料的过程中。

公开(公告)号：KR100874125B1

公开(公告)日：2008-12-15

申请号：KR1020070068895

申请日：2007-07-09

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  김화용 ,  주준호 ,  신내철

IPC: C07D501/34 ,  C07D501/36 ,  C07D501/12

CPC classification number: Y02P20/544 ,  C07D501/12 ,  C07D501/34

Abstract: A method for preparing cefpodoxime proxetil is provided to remove a remaining solvent nearly or completely by carrying out the drying process by using supercritical and subcritical carbon dioxide. A method for preparing cefpodoxime proxetil comprises the step of drying it by using the supercritical and subcritical carbon dioxide at a temperature of 0-70 deg.C and at a pressure of 35-600 atm. to remove the remaining organic solvent.

Abstract translation: 提供制备头孢泊肟酯的方法，通过使用超临界和亚临界二氧化碳进行干燥过程，几乎或完全地除去残留的溶剂。 制备头孢泊肟原料的方法包括使用超临界和亚临界二氧化碳在0-70℃和35-600atm压力下干燥方法。 以除去剩余的有机溶剂。