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公开(公告)号：KR1020090060787A
公开(公告)日：2009-06-15
申请号：KR1020070127723
申请日：2007-12-10
Applicant: 재단법인서울대학교산학협력재단
IPC: A01N63/00
CPC classification number: A61K31/7076 , C07H19/167
Abstract: A novel sorangiadenosine compound having antibacterial activity, which is isolated from a Sorangium cellulosum is provided to have inhibition activity against gram-positive bacteria and gram-negative bacteria and treat disease caused by bacterial infection. A novel sesqui-terpene adenoside compound of the general formula I is isolated from a Sorangium cellulosum. In the general formula I, R1-R11 are independently hydrogen, halogen group, nitro group, amine group, hydroxyl group, C1-C5 low alkoxyl group, sulfhydryl group, sulfonyl group, carboxyl group, C1-C5 low alkyl ester group, C1-C20 alkyl group, C2-C20 alkenyl group or C2-C20 alkynyl group. A antibacterial composition for treating disease caused by bacterial infection comprises a sorangiadenosine compound of the general formula I and its pharmaceutically allowable salt. The disease caused by bacteria infection is staphylococcus food poisoning, cellubitis, scull furnace infection meningitis, peritonitis, cystitis, lymphangitis, panaritium, tympanitis, and respiratory disease.
Abstract translation: 提供具有抗菌活性的新颖的具有抗菌活性的山梨酸腺苷化合物，其从纤维素酵母中分离，以对革兰氏阳性细菌和革兰氏阴性细菌具有抑制活性并治疗由细菌感染引起的疾病。 通式Ⅰ的新型倍半萜类腺苷化合物是从纤维素中分离的。 在通式Ⅰ中，R1-R11独立地为氢，卤素基，硝基，胺基，羟基，C1-C5低级烷氧基，巯基，磺酰基，羧基，C1-C5低级烷基酯基，C1 -C 20烷基，C 2 -C 20烯基或C 2 -C 20炔基。 用于治疗由细菌感染引起的疾病的抗菌组合物包含通式I的山梨酸腺苷化合物及其药学上可允许的盐。 由细菌感染引起的疾病是葡萄球菌食物中毒，纤维蛋白溶解症，脊髓炎感染脑膜炎，腹膜炎，膀胱炎，淋巴管炎，泛黄，鼓膜炎和呼吸系统疾病。
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公开(公告)号：KR100962843B1
公开(公告)日：2010-06-10
申请号：KR1020070127723
申请日：2007-12-10
Applicant: 재단법인서울대학교산학협력재단
IPC: A01N63/00
Abstract: 본 발명은 점액세균(Sorangium cellulosum)으로부터 분리한 항균 활성을 갖는 신규 화합물 및 이를 유효성분으로 함유하는 항균조성물에 관한 것으로, 상세하게는 점액세균(Sorangium cellulosum)의 배양액에서 세스퀴테르펜 아데노사이드계 화합물인 신규 소란지아데노신 화합물을 분리하여 다양한 그램양성 및 그램음성 박테리아에 대한 강한 저해활성을 확인함으로써, 이를 포함하는 조성물은 세균 감염성 질병의 치료를 위한 조성물로 유용하게 이용될 수 있다.
소란지아데노신, 세스퀴테르펜 아데노사이드, 점액세균, 항균조성물
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