公开(公告)号：KR100796458B1

公开(公告)日：2008-01-21

申请号：KR1020060098291

申请日：2006-10-10

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신종헌 ,  김상희 ,  김태윤 ,  장현욱 ,  이봉호 ,  최병욱

IPC: C07C69/18 ,  C07C69/67

Abstract: An octadecatetraenoyl glycerol compound or a pharmaceutically acceptable derivative thereof is provided to prevent and treat inflammatory diseases, allergies, and asthma by inhibiting an activity of 5-lipoxygenase and showing a strong inhibitory activity against phospholipase A2. An octadecatetraenoyl glycerol compound or a pharmaceutically acceptable derivative thereof has a structure represented by the formula (A). A method for separating the octadecatetraenoyl glycerol compound includes the steps of: (1) extracting Sargassum sagamianum with water or methanol to obtain a crude extract; (2) evaporating a solvent of the crude extract under reduced pressure to obtain a residue, and obtaining fractions from the residue according to polarities thereof; and (3) evaporating a solvent of the fractions to obtain an organic concentrate, and then purifying and isolating the organic concentrate by chromatography.

Abstract translation: 提供十八四烯酰甘油化合物或其药学上可接受的衍生物，通过抑制5-脂氧合酶的活性并显示出对磷脂酶A2的强抑制活性来预防和治疗炎性疾病，过敏和哮喘。 十八四烯酰基甘油化合物或其药学上可接受的衍生物具有由式（A）表示的结构。 分离十八四烯酰甘油化合物的方法包括以下步骤：（1）用水或甲醇萃取马齿苋，得到粗提物; （2）减压蒸发粗提取物的溶剂，得到残渣，根据其极性从残渣中得到馏分; 和（3）蒸发馏分的溶剂，得到有机浓缩物，然后通过色谱法纯化和分离有机浓缩物。

公开(公告)号：KR100812827B1

公开(公告)日：2008-03-17

申请号：KR1020060098290

申请日：2006-10-10

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신종헌 ,  김상희 ,  김태윤 ,  장현욱 ,  이봉호 ,  최병욱

IPC: A61K36/03 ,  A61P37/08 ,  A61P11/06

Abstract: An extract of Sargassum sagamianum is provided to inhibit the activity of 5-lipoxygenase(5-LO) and generation of cyclooxygenase-2(COX2-) dependent prostaglandin D2(PGD2) and show strong inhibitory activity on phospholipase A2, thereby being usefully used for preventing or treating inflammation, allergy and asthma. A pharmaceutical composition for preventing and treating rheumatoid arthritis, allergic rhinitis, allergic asthma or allergic dermatitis comprises 0.1-50 wt.% of an extract of Sargassum sagamianum using a solvent of methanol, dichloromethane or acetone as an effective ingredient. A health functional food for preventing and treating rheumatoid arthritis, allergic rhinitis, allergic asthma or allergic dermatitis comprises the extract of Sargassum sagamianum.

Abstract translation: 提供Sargassum sagamianum的提取物以抑制5-脂氧合酶（5-LO）的活性和环氧合酶-2（COX2-）依赖性前列腺素D2（PGD2）的产生，并且对磷脂酶A2显示出强的抑制活性，从而有效地用于 预防或治疗炎症，过敏和哮喘。 用于预防和治疗类风湿性关节炎，过敏性鼻炎，过敏性哮喘或过敏性皮炎的药物组合物，使用甲醇，二氯甲烷或丙酮的溶剂作为有效成分，含有0.1-50重量％的Sargassum sagamianum的提取物。 用于预防和治疗类风湿性关节炎，过敏性鼻炎，过敏性哮喘或过敏性皮炎的健康功能食品包括Sargassum sagamianum的提取物。

公开(公告)号：KR1020030039509A

公开(公告)日：2003-05-22

申请号：KR1020010070448

申请日：2001-11-13

Applicant: 재단법인서울대학교산학협력재단 ,  김현표 ,  손건호 ,  장현욱

Inventor： 강삼식 ,  장현욱 ,  손건호 ,  김현표

IPC: A61K8/49 ,  A61K8/97 ,  A61Q19/02

CPC classification number: A61K8/97 ,  A61K8/498 ,  A61Q19/00 ,  A61Q19/02

Abstract: PURPOSE: Provided is a skin whitening agent containing sophoraflavanone G, derivatives thereof and a sophorae radix extract containing the same which directly inhibit tyrosinase activity, reduce the amount of melamine in melanoma cells and have low toxicity. CONSTITUTION: The skin whitening agent composition contains sophoraflavanone G represented by the formula(1) and a derivative thereof as an active ingredient. A sophorae radix extract is obtained by extraction in a single or two or more mixed solvents selected from water, C1-4 lower alcohol, glycerol, propylene glycol, 1,3-butylene glycol, ethyl acetate, benzene, hexane and diethyl ether. The sophorae radix extract contains the sophoraflavanone G and derivatives thereof.

Abstract translation: 目的：提供含有槐花素G，其衍生物和含有它们的堇菜提取物的皮肤增白剂，其直接抑制酪氨酸酶活性，减少黑素瘤细胞中三聚氰胺的量并具有低毒性。 构成：皮肤美白剂组合物含有由式（1）表示的槐紫豆酮G及其衍生物作为活性成分。 通过在选自水，C 1-4低级醇，甘油，丙二醇，1,3-丁二醇，乙酸乙酯，苯，己烷和乙醚中的一种或两种或更多种混合溶剂中萃取获得槐提取物。 槐提取物含有槐花素G及其衍生物。

公开(公告)号：KR100796459B1

公开(公告)日：2008-01-21

申请号：KR1020060098619

申请日：2006-10-10

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신종헌 ,  김상희 ,  김태윤 ,  장현욱 ,  이봉호 ,  최병욱

IPC: C07C69/16

Abstract: A fatty acid glycerol derivative is provided to inhibit the formation of cyclooxygenase-2-dependent prostaglandin D2, to ensure a strong inhibitory activity against phospholipase A2, thereby preventing and treat inflammatory diseases, allergies, and asthma. A method for preparing a compound of the structural formula (B) and a palmitoyl glycerol, stearoyl glycerol, oleoyl glycerol, linoleoyl glycerol, gamma-linolenoyl glycerol, alpha-linolenoyl glycerol, dihomo-gamma-linolenoyl glycerol, eicosapentaenoyl glycerol, adrenoyl glycerol, or docosahexaenoyl glycerol derivative compound includes the steps of: (1) condensing a fatty acid of the formula (I) and a cyclized glycerol of the formula (II) to obtain an ester of the formula (III); purifying the ester compound by chromatography; (3) decyclizing the pured ester with a boric acid as a reducing agent to synthesize fatty acid glycerol of the formula (IV); and (4) purifying the synthesized compound by chromatography.

Abstract translation: 提供脂肪酸甘油衍生物以抑制环氧合酶-2依赖性前列腺素D2的形成，以确保对磷脂酶A2的强抑制活性，从而预防和治疗炎性疾病，过敏反应和哮喘。 制备结构式（B）的化合物和棕榈酰甘油，硬脂酰甘油，油酰甘油，亚油酰甘油，γ-亚麻酰基甘油，α-亚麻酸酰甘油，二高-γ-亚麻油酰甘油，二十碳五烯酰甘油，肾上腺素甘油， 或二十二碳六烯酰基甘油衍生物化合物包括以下步骤：（1）将式（I）的脂肪酸与式（II）的环化甘油缩合得到式（III）的酯; 通过色谱纯化酯化合物; （3）用硼酸作为还原剂使得该酯脱酯，合成式（IV）的脂肪酸甘油; 和（4）通过色谱法纯化合成的化合物。