公开(公告)号：KR1020090085173A

公开(公告)日：2009-08-07

申请号：KR1020080010920

申请日：2008-02-04

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강헌중 ,  진정욱 ,  탁정애

IPC: C07C391/02

Abstract: A method for manufacturing an alkyl aryl selenide derivative is provided to prepare an alkyl aryl selenide derivative with a single process without separation and refining process of intermediate from various aryl halogen compounds. An alkyl aryl selenide derivative has a structure represented by chemical formula 1. In chemical formula 1, A is CR11 or N; B is a functional group of chemical formula 1a and a functional group of chemical formula 1b; R1 is substituted or unsubstituted (C1-C7) alkyl, (C1-C7) alkoxy, (C1-C7) alkylthio, (C6-C12) aryl, halogen, amino, amino (C1-C7) alkyl, hydroxyl, hydroxy (C1-C7) alkyl or carboxylic acid; R2 is (C1-C10) alkyl, (C6-C12) aryl, (C1-C10) alkoxycarbonyl, (C1-C10) alkylcarbonyl or (C6-C12) arylcarbonyl; R3 is (C1-C7) alkyl or (C6-C12) aryl; R11 hydrogen, halogen-substituted or unsubstituted (C1-C7) alkyl, (C1-C7) alkoxy, (C1-C7) alkylthio, (C6-C12) aryl, halogen, amino, amino (C1-C7) alkyl, hydroxyl, hydroxy (C1-C7) alkyl or carboxylic acid; and m is an integer of 1-4.

Abstract translation: 提供一种制备烷基芳基硒化物衍生物的方法，以制备一种单一工艺的烷基芳基硒化物衍生物，而不需要从各种芳基卤素化合物中分离和精制过程。 烷基芳基硒化物衍生物具有由化学式1表示的结构。在化学式1中，A是CR 11或N; B是化学式1a的官能团和化学式1b的官能团; （C1-C7）烷基，（C1-C7）烷硫基，（C6-C12）芳基，卤素，氨基，氨基（C1-C7）烷基，羟基，羟基（C1 -C 7）烷基或羧酸; R2是（C1-C10）烷基，（C6-C12）芳基，（C1-C10）烷氧基羰基，（C1-C10）烷基羰基或（C6-C12）芳基羰基; R3是（C1-C7）烷基或（C6-C12）芳基; （C1-C7）烷氧基，（C1-C7）烷硫基，（C6-C12）芳基，卤素，氨基，氨基（C1-C7）烷基，羟基， 羟基（C 1 -C 7）烷基或羧酸; m为1-4的整数。

公开(公告)号：KR100951653B1

公开(公告)日：2010-04-07

申请号：KR1020070124052

申请日：2007-12-01

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강헌중 ,  진정욱 ,  이재환

IPC: C07C323/20 ,  C07C323/18 ,  C07D413/04 ,  C07D261/08

CPC classification number: C07C391/02 ,  A23K20/111 ,  A23L33/10 ,  C07C323/20 ,  C07D213/32 ,  C07D261/08

Abstract: 본 발명은 퍼록시솜 증식자 활성화 수용체 (Peroxisome Proliferator Activated Receptor , 이하 'PPAR'로 표시함)에 활성을 갖는 하기 화학식(Ⅰ)으로 표시되는 화합물, 그의 수화물, 그의 용매화물, 그의 입체 이성체, 그의 약학적으로 허용되는 염, 이를 포함하는 의약, 화장품 조성물, 근육강화제, 기억력 증진제, 치매 및 파킨슨병 치료제, 기능성 식품 및 동물용 사료 조성물에 관한 것이다.
[화학식 I]

상기 화학식 1에서 A는 S 또는 Se이다.
퍼록시솜 증식자 활성화 수용체, 비만, 당뇨, 고지혈증, 동맥경화, 화장품, 근육강화제, 기억력 증진제, 치매 및 파킨슨병 치료제, 기능성식품, 동물용 사료 조성물

公开(公告)号：KR1020080050348A

公开(公告)日：2008-06-05

申请号：KR1020070124052

申请日：2007-12-01

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강헌중 ,  진정욱 ,  이재환

IPC: C07C323/20 ,  C07C323/18 ,  C07D413/04 ,  C07D261/08

CPC classification number: C07C391/02 ,  A23K20/111 ,  A23L33/10 ,  C07C323/20 ,  C07D213/32 ,  C07D261/08

Abstract: An aryl compound as a peroxisome poliferator activated receptor(PPAR) ligand is provided to realize a high selective activation degree to PPAR and to give a pharmaceutical composition, cosmetic composition, anabolic agent, memory enhancing agent, agent for treating dementia or Parkinson's disease, functional food and animal feed composition. An aryl compound as a PPAR ligand is a compound represented by the following formula (I), or hydrate, solvate, stereoisomer or pharmaceutically acceptable salt thereof. In formula (I), A is S or Se; B is H or the formula (a); R1 is an aryl group selected from the formula (b); R2 is H, C1-C8 alkyl or the formula (c); R3 is H, a C1-C8 alkyl or halogen; each of R4 and R5 is H or a C1-C8 alkyl; R6 is H, a C1-C8 alkyl, C2-C7 alkenyl, alkali metal or alkaline earth metal; each of R11 and R12 is H, a C1-C8 alkyl or halogen; R21 is H, a halogen. C1-C7 alkyl, heterocyclic group or C1-C7 alkoxy group; each of m and n is an integer of 1-4; p is an integer of 1-5; q is an integer of 1-4; r is an integer of 1-3; and s is an integer of 1-5, wherein the alkyl and alkoxy of R2, R3, R4, R5, R6, R11, R12 and R21 are optionally substituted with at least one halogen or C1-C5 alkylamine, with the proviso that a compound wherein R2 is H and A is S is excluded.

Abstract translation: 提供了作为过氧化物酶体增殖物激活受体（PPAR）配体的芳基化合物以实现对PPAR的高选择性活化度，并得到药物组合物，化妆品组合物，合成代谢剂，记忆增强剂，治疗痴呆或帕金森病的药剂，功能性 食物和动物饲料组成。 作为PPAR配体的芳基化合物是由下式（I）表示的化合物或其水合物，溶剂化物，立体异构体或其药学上可接受的盐。 在式（I）中，A是S或Se; B为H或式（a）; R1是选自式（b）的芳基; R2是H，C1-C8烷基或式（c）; R3是H，C1-C8烷基或卤素; R 4和R 5各自为H或C 1 -C 8烷基; R6是H，C1-C8烷基，C2-C7链烯基，碱金属或碱土金属; R 11和R 12各自为H，C 1 -C 8烷基或卤素; R21是H，卤素。 C1-C7烷基，杂环基或C1-C7烷氧基; m和n各自为1-4的整数; p为1-5的整数; q为1-4的整数; r为1-3的整数; 并且s是1-5的整数，其中R 2，R 3，R 4，R 5，R 6，R 11，R 12和R 21的烷基和烷氧基任选被至少一个卤素或C 1 -C 5烷基胺取代，条件是a 不包括R2为H且A为S的化合物。

公开(公告)号：KR1020040039869A

公开(公告)日：2004-05-12

申请号：KR1020020068099

申请日：2002-11-05

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강헌중 ,  함정엽 ,  진정욱

IPC: C07J13/00

CPC classification number: C07J13/007 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/3262 ,  A61K31/56 ,  C07B33/00

Abstract: PURPOSE: Provided are a preparation method of guggulsterone to produce guggulsterone simply and in a high yield, and an intermediate used in the preparation method. CONSTITUTION: The preparation method of guggulsterone represented by formula 1 comprises the steps of: preparing a compound represented by formula 3 by reacting a compound represented by formula 2 with ethylene triphenyl phosphine ylide(Ph 3 P=CHCH 3 ylide) in an anhydrous organic solvent; preparing a compound represented by formula 4 by reacting a compound represented by formula 3 with selenium oxide and selenium hydrogen peroxide in an organic solvent; and oxidizing a compound represented by formula 4.

Abstract translation: 目的：提供甘草酮简单地且高产率地制备吉格斯酮的制备方法和制备方法中使用的中间体。 构成：由式1表示的苦瓜酮的制备方法包括以下步骤：通过将式2化合物与乙烯三苯基膦内鎓盐（Ph 3 P = CHCH 3叶立德）在无水有机溶剂中反应制备式3化合物 ; 通过在有机溶剂中使由式3表示的化合物与氧化硒和过氧化硒反应制备式4化合物; 并氧化由式4表示的化合物。