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1.发明公开알파-일레오스테아르산을 포함하는 유방암 치료용 조성물및 이를 이용한 피피에이알γ 활성 조절에 의한 질환의치료방법 无效用于治疗包含ALPHA-ELEOSTEACIC酸的乳腺癌的组合物和通过使用其调节PPARγ活性来治疗疾病的方法
公开(公告)号：KR1020090012520A
公开(公告)日：2009-02-04
申请号：KR1020070076422
申请日：2007-07-30
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 리포젠
Abstract: A composition for treatment of breast cancer is provided to investigate anti-cancer capability and mechanism in MCF-7 breast cancer cell using alpha-eleostearic acid. A composition for treatment of breast cancer includes alpha-eleostearic acid to active ingredient. A remedial method of disease at cancer cell line includes a step of processing the alpha-eleostearic acid of a therapeutically effective amount to the cancer cell line and prevents, suppresses or improves pathology or symptom of diseases by adjustment of PPAR gamma activity or phosphorylation of ERK1/2.
Abstract translation: 提供了一种用于治疗乳腺癌的组合物，用于研究使用α-蒿酸的MCF-7乳腺癌细胞的抗癌能力和机制。 用于治疗乳腺癌的组合物包括对活性成分的α-蒿酸。 在癌细胞系疾病的补救方法包括将治疗有效量的α-蒿酸处理至癌细胞系的步骤，通过调整PPARγ活性或ERK1磷酸化来预防，抑制或改善疾病的病理学或症状 / 2。
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公开(公告)号：KR1020050029582A
公开(公告)日：2005-03-28
申请号：KR1020030065919
申请日：2003-09-23
IPC: A61K47/48
CPC classification number: A61K47/62 , A23L33/12 , A23V2002/00 , A23V2200/30 , A23V2250/1866 , A61K31/201
Abstract: An antioxidation composition comprising arginine-conjugated linoleic acid is provided, which arginine-conjugated linoleic acid(Arg-CLA) complex has improved inhibitory effect on oxidative damage, so that the Arg-CLA complex is useful in antioxidation food composition and medicinal composition. The antioxidation composition comprises 0.02 to 10 parts by weight of arginine-conjugated linoleic acid complex as an effective component, wherein the antioxidation composition inhibits arteriosclerosis, heart disease, dementia, skin aging or diabetes; the composition is dietary supplement or food additive; and the composition further comprises pharmaceutically acceptable carriers.
Abstract translation: 提供了包含精氨酸共轭亚油酸的抗氧化组合物，精氨酸共轭亚油酸（Arg-CLA）配合物对氧化损伤具有改善的抑制作用，因此Arg-CLA复合物可用于抗氧化食品组合物和药物组合物。 抗氧化组合物含有0.02〜10重量份的精氨酸共轭亚油酸配合物作为有效成分，其中抗氧化组合物抑制动脉硬化，心脏病，痴呆，皮肤老化或糖尿病; 该组合物是膳食补充剂或食品添加剂; 并且组合物还包含药学上可接受的载体。
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公开(公告)号：KR1020030053484A
公开(公告)日：2003-06-28
申请号：KR1020030030853
申请日：2003-05-15
Applicant: 주식회사 리포젠
IPC: C11B1/00
CPC classification number: C11B1/10 , A23L33/12 , A61K31/201
Abstract: PURPOSE: A water-soluble lipid composite containing a basic amino acid and its preparation method are provided, to convert a highly functional unsaturated fatty acid into a water-soluble lipid applicable to various uses. CONSTITUTION: The water-soluble lipid composite is prepared by reacting a highly functional unsaturated fatty acid having 16-24 carbons and 1-6 double bonds with an amino acid, and is characterized by the intense peaks at 1560 cm¬-1 and 1395 cm¬-1 which represent the characteristic peak of COO- in a salt state. Preferably the unsaturated fatty acid is at least one selected from the group consisting of γ-linolenic acid, γ-linolenic acid, oleic acid, elaidic acid, linoleic acid, conjugated linoleic acid, docasahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid; and the basic amino acid is arginine, lysine or histidine.
Abstract translation: 目的：提供含有碱性氨基酸的水溶性脂质复合物及其制备方法，将高官能不饱和脂肪酸转化为适用于各种用途的水溶性脂质。 构成：通过使具有16-24个碳原子和1-6个双键的高官能不饱和脂肪酸与氨基酸反应制备水溶性脂质复合物，其特征在于1560cm -1和1395cm处的强峰 ¬-1表示盐状态下COO-的特征峰。 优选不饱和脂肪酸为选自γ-亚麻酸，γ-亚麻酸，油酸，反油酸，亚油酸，共轭亚油酸，二十二碳六烯酸（DHA），二十碳五烯酸（EPA）和 花生四烯酸; 碱性氨基酸为精氨酸，赖氨酸或组氨酸。
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公开(公告)号：KR1020050030061A
公开(公告)日：2005-03-29
申请号：KR1020030066376
申请日：2003-09-24
IPC: A61K47/48
CPC classification number: A61K47/62 , A23L33/12 , A23V2002/00 , A23V2200/324 , A23V2250/1866 , A61K31/201
Abstract: An anti-inflammatory composition comprising arginine-conjugated linoleic acid is provided, which arginine-conjugated linoleic acid(Arg-CLA) complex has improved inhibitory effect on inflammation occurred by endotoxin of bacterium, so that the Arg-CLA complex is useful in anti-inflammatory food composition and medicinal composition. The anti-inflammatory composition comprises 0.02 to 10 parts by weight of arginine-conjugated linoleic acid complex as an effective component, wherein the anti-inflammatory composition is applicable for prevention and treatment of formation of TNF-alpha(tumor necrosis factor-alpha), prostaglandin E-2 and nitric oxide(NO) by endotoxin of bacterium; the composition is a food composition of dietary supplement or food additive; and the composition further comprises pharmaceutically acceptable carriers.
Abstract translation: 提供了包含精氨酸共轭亚油酸的抗炎组合物，精氨酸共轭亚油酸（Arg-CLA）配合物对细菌内毒素发生的炎症抑制作用改善，使得Arg-CLA复合物可用于抗 - 炎症食物组成和药物组成。 抗炎组合物含有0.02〜10重量份的精氨酸共轭亚油酸配合物作为有效成分，其中抗炎组合物适用于预防和治疗TNF-α（肿瘤坏死因子-α）的形成， 前列腺素E-2和一氧化氮（NO）细菌内毒素; 该组合物是膳食补充剂或食品添加剂的食物组合物; 并且组合物还包含药学上可接受的载体。
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公开(公告)号：KR100900030B1
公开(公告)日：2009-06-01
申请号：KR1020070100303
申请日：2007-10-05
Applicant: 주식회사 리포젠
Abstract: 본 발명은 고순도의 불포화지방산의 제조방법에 관한 것으로서, 본 발명은 포화지방산을 선택적으로 포접하여 제거하기 위한 요소의 활성을 증대시키기 위하여, 기존 인체에 유해한 유기용매를 사용하는 대신에, 고온 및 감압 조건하에서 진공 분무건조기를 이용하여 건조한 반응성이 극대화된 기활성화 요소를 사용한다. 이에, 유리지방산으로부터 포화지방산을 효과적으로 제거할 수 있어, 함량이 최대화된 고순도 불포화지방산을 제조할 수 있다. 특히, 공역리놀레산(conjugated linoleic acid)의 생리활성을 위해 공역화된 특정 이성체의 함량이 중요한데, 본 발명에 의해 제조되는 공역리놀레산은 생리활성을 나타내는 시스-9, 트랜스-11 C18:2 및 트랜스-10, 시스-12 C18:2의 두 이성체의 함량을 최대화하고, 상기 두 이성체의 함량비를 일정하기 유지함으로써, 본 발명은 기능성 및 안전성을 극대화한 공역리놀레산을 제조 할 수 있다. 또한, 본 발명은 보다 간단하고 효율적인 공정으로 저렴하게 고순도 불포화지방산을 대량생산할 수 있다.
불포화 지방산, 리놀레산, 감마-리놀렌산, 공역리놀레산, 분무건조기-
Patent Agency Ranking
公开(公告)号：KR100693150B1
公开(公告)日：2007-03-13
申请号：KR1020050028615
申请日：2005-04-06
Applicant: 주식회사 리포젠
IPC: A23L1/29
Abstract: 본 발명은 다음 화학식 1로 표시되는 재구성 트리글리세라이드를 포함하는 것을 특징으로 하는 아라키돈산-공급원이면서 아라키돈산의 생체내 부작용 억제용 식품 보충물 조성물에 관한 것이다:
화학식 1
상기 화학식에서, R
1 , R
2 및 R
3 중 적어도 하나는 아라키돈산이고 그리고 적어도 하나는 감마-리놀렌산이다.
본 발명의 식품 보충물 조성물은 아라키돈산을 유아식에 적용하는데 있어서 아라키돈산의 긍정적 대사작용을 도우며, 동시에 아라키돈산의 과잉대사로 인한 염증성 질환의 부작용 발현 가능성을 최소화하며, 포화지방산 등 기타 지질들을 최소화한 기능성 지방산 조성물을 공급할 수 있다.
재구성 지질, 아라키돈산, 감마-리놀렌산, 트리글리세라이드, 식품-
公开(公告)号：KR1020050029581A
公开(公告)日：2005-03-28
申请号：KR1020030065918
申请日：2003-09-23
IPC: A61K47/48
CPC classification number: A61K47/62 , A23L33/12 , A23V2002/00 , A23V2200/308 , A23V2250/1866 , A61K31/201
Abstract: An anticancner composition comprising arginine-conjugated linoleic acid is provided, which arginine-conjugated linoleic acid(Arg-CLA) complex has improved inhibitory effect on stomach cancer, so that the Arg-CLA complex is useful in anticancer food composition and medicinal composition. The anticancner composition comprises 0.02 to 10 parts by weight of arginine-conjugated linoleic acid complex as an effective component, wherein the cancer is colon cancer, stomach cancer, breast cancer or skin cancer; the composition is dietary supplement or food additive; and the composition further comprises pharmaceutically acceptable carriers.
Abstract translation: 提供了包含精氨酸共轭亚油酸的抗癌组合物，其中精氨酸共轭亚油酸（Arg-CLA）复合物对胃癌具有改善的抑制作用，因此Arg-CLA复合物可用于抗癌食物组合物和药物组合物。 抗癌剂组合物含有0.02〜10重量份的精氨酸共轭亚油酸复合物作为有效成分，其中癌症是结肠癌，胃癌，乳腺癌或皮肤癌; 该组合物是膳食补充剂或食品添加剂; 并且组合物还包含药学上可接受的载体。
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公开(公告)号：KR1020090035175A
公开(公告)日：2009-04-09
申请号：KR1020070100303
申请日：2007-10-05
Applicant: 주식회사 리포젠
Abstract: A method for manufacturing a highly pure unsaturated fatty acid is provided to mass-produce the highly pure unsaturated fatty acid with a simple and efficient process by removing the saturated fatty acid from the free fatty acid. A method for manufacturing a highly pure unsaturated fatty acid comprises the steps of: (a) preparing pre-activated urea by drying the aqueous urea solution with a vacuum spray dryer; (b) injecting the free fatty acid obtained by hydrolyzing vegetable oil in a reactor; (c) injecting and mixing the pre-activated urea prepared in the (a) step in the reactor of (b) step; (d) removing the saturated fatty acid by filtering the mixture of (c) step; and (d) distilling the free fatty acid filtered in the (d) step.
Abstract translation: 提供一种制造高纯度不饱和脂肪酸的方法，通过从游离脂肪酸中除去饱和脂肪酸，以简单有效的方法大量生产高纯度不饱和脂肪酸。 制造高纯度不饱和脂肪酸的方法包括以下步骤：（a）通过用真空喷雾干燥器干燥尿素水溶液来制备预活化的尿素; （b）将在反应器中水解植物油获得的游离脂肪酸注入; （c）在（b）步骤的反应器中注入和混合在（a）步骤中制备的预活化脲; （d）通过过滤（c）步骤的混合物除去饱和脂肪酸; 和（d）蒸馏在（d）步骤中过滤的游离脂肪酸。
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公开(公告)号：KR1020060106161A
公开(公告)日：2006-10-12
申请号：KR1020050028615
申请日：2005-04-06
Applicant: 주식회사 리포젠
IPC: A23L1/29
CPC classification number: A23L33/00 , A23L33/105
Abstract: 본 발명은 다음 화학식 1로 표시되는 재구성 트리글리세라이드를 포함하는 것을 특징으로 하는 아라키돈산-공급원이면서 아라키돈산의 생체내 부작용 억제용 식품 보충물 조성물에 관한 것이다:
화학식 1
상기 화학식에서, R
1 , R
2 및 R
3 중 적어도 하나는 아라키돈산이고 그리고 적어도 하나는 감마-리놀렌산이다.
본 발명의 식품 보충물 조성물은 아라키돈산을 유아식에 적용하는데 있어서 아라키돈산의 긍정적 대사작용을 도우며, 동시에 아라키돈산의 과잉대사로 인한 염증성 질환의 부작용 발현 가능성을 최소화하며, 포화지방산 등 기타 지질들을 최소화한 기능성 지방산 조성물을 공급할 수 있다.
재구성 지질, 아라키돈산, 감마-리놀렌산, 트리글리세라이드, 식품-
公开(公告)号：KR1020050029583A
公开(公告)日：2005-03-28
申请号：KR1020030065920
申请日：2003-09-23
IPC: A61K47/48
CPC classification number: A61K47/62 , A23L33/12 , A23V2002/00 , A23V2200/332 , A23V2250/1866 , A61K31/201
Abstract: An anti-obesity composition comprising arginine-conjugated linoleic acid is provided, which arginine-conjugated linoleic acid(Arg-CLA) complex has improved inhibitory effect on obesity, so that the Arg-CLA complex is useful in anti-obesity food composition and medicinal composition. The anti-obesity composition comprises 0.02 to 10 parts by weight of arginine-conjugated linoleic acid complex as an effective component, wherein the anti-obesity composition is applicable for prevention and treatment of obesity; the composition is a food composition of dietary supplement or food additive; and the composition further comprises pharmaceutically acceptable carriers.
Abstract translation: 提供了包含精氨酸共轭亚油酸的抗肥胖组合物，精氨酸共轭亚油酸（Arg-CLA）复合物对肥胖症具有改善的抑制作用，因此Arg-CLA复合物可用于抗肥胖食物组合物和药物 组成。 抗肥胖组合物含有0.02〜10重量份的作为有效成分的精氨酸共轭亚油酸配合物，其中，抗肥胖组合物可用于预防和治疗肥胖症; 该组合物是膳食补充剂或食品添加剂的食物组合物; 并且组合物还包含药学上可接受的载体。
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